DUFMech

All families / PF07757

PF07757: AdoMet_MTase

Predicted AdoMet-dependent methyltransferase

Curation status
SEEDED
Seed status
EX DUF
Characterization
UNSCORED

Grounding

PF07757: Predicted AdoMet-dependent methyltransferase
IPR011671: integrated entry for Predicted AdoMet-dependent methyltransferase

Source description

Proteins in this family have been predicted to function as AdoMet-dependent methyltransferases [InterPro reference PUB00044770].

Evidence and references

Source descriptions and links are provenance, not independent functional validation.

Evidence counts: not scored.

Curated functional assertions

No curated functional assertions supplied.

Protein sequence examples

7 verified sequence examples. FASTA

UniProtProtein / organismSequenceProvenance
O74516tRNA (uracil-O(2)-)-methyltransferase
Schizosaccharomyces pombe (strain 972 / ATCC 24843)		502 aa; version 1
UniProt 2026_03		UNIPROT FETCH
1 sibling references
Q02648tRNA (uracil-O(2)-)-methyltransferase
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)		567 aa; version 1
UniProt 2026_03		PTM REGISTRY MIRROR
6 sibling references
Q45EK7Probable tRNA (uracil-O(2)-)-methyltransferase
Caenorhabditis elegans		563 aa; version 1
UniProt 2026_03		UNIPROT FETCH
3 sibling references
Q6CR42tRNA (uracil-O(2)-)-methyltransferase
Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)		537 aa; version 1
UniProt 2026_03		UNIPROT FETCH
1 sibling references
Q8IYL2Probable tRNA (uracil-O(2)-)-methyltransferase
Homo sapiens		757 aa; version 2
UniProt 2026_03		UNIPROT FETCH
3 sibling references
Q9D2Q2Probable tRNA (uracil-O(2)-)-methyltransferase
Mus musculus		713 aa; version 2
UniProt 2026_03		UNIPROT FETCH
2 sibling references
Q9VHB9Probable tRNA (uracil-O(2)-)-methyltransferase
Drosophila melanogaster		521 aa; version 2
UniProt 2026_03		UNIPROT FETCH
1 sibling references

Pfam membership is not functional evidence. Whole-protein sequences do not establish domain boundaries. A coverage gap here is not absence from UniProt.

Sequences and metadata: UniProt Consortium, CC BY 4.0.

Domain matches

No residue-level domain match evidence is available in this build. Structure and AlphaFold counters do not supply coordinates or establish function.

Snapshot counters

proteins
2,780
matches
3,115
proteomes
2,426
taxa
6,435
structures
0
alphafold models
2,351
domain architectures
49

Classification basis

pfam previous unknown name

No scoring reasons supplied.

Related Mech records

This family joined the worklist after the frozen cross-Mech scan, so other Mechs were not searched for it. Missing links here are not evidence that other Mechs lack it; rows shown come from mentions of a former DUF/UPF name.

No cross-Mech examples are present in the supplied snapshot.

Curation history and reviews

No retained curation events supplied.

No retained review supplied.

Record source

data/families/PF07757.yaml
Family YAML in this build

Download this family (JSON)

Status and evidence

Seed status
A name-based classification of frozen InterPro/Pfam metadata. UNKNOWN CANDIDATE means the metadata explicitly says the function is unknown. KNOWN HISTORICAL DUF means a DUF name matched without that wording; this heuristic is not proof of a known function and does not establish experimental characterization. EX DUF means Pfam renamed the family away from a DUF/UPF name, as recorded in Pfam's previous identifiers; a rename usually follows published work on some members but is naming history, not proof of function for every member. Some EX DUF families' current names or descriptions still say the function is unknown; their classification basis lists this, and scoring does not treat them as characterized. FALSE POSITIVE TEXT HIT means the naming rules did not match.
Characterization
A separate evidence-scoring result. UNSCORED means no score has been calculated; it is not evidence that the family lacks a known function. Missing scores are not negative evidence. PARTIALLY CHARACTERIZED has partial support; KNOWN HISTORICAL DUF can inherit the seed label or reflect a known-function signal. Neither label implies experimental validation.
Evidence counts
Source-specific signals, not unique proteins, publications, or confidence scores. Known counts Rhea reactions and experimentally supported GO molecular-function annotations. Partial counts functional/domain assignments. Context counts structural, environmental, orthology, interaction and neighborhood signals; context alone does not assign function. Repeated annotations may not be independent.
Curation status
Reported separately from seed classification and characterization. SNAPSHOT ONLY means no curated metadata was supplied for this build. SEEDED denotes a source-derived record, not an expert-reviewed functional claim.
Missing counts
Not available means the source did not supply that counter. A zero is a reported count. Not scored means evidence counts are unavailable.