DUFMech

All families / PF08742

PF08742: C8

C8 domain

Curation status
SEEDED
Seed status
EX DUF
Characterization
UNSCORED

Grounding

PF08742: C8 domain
IPR014853: integrated entry for C8 domain

Source description

This domain contains 8 conserved cysteine residues, but this family only contains 7 of them to overlaps with other domains. It is found in disease-related proteins including von Willebrand factor, Alpha tectorin, Zonadhesin and Mucin. It is often found on proteins containing PF00094 (Pfam entry) and PF01826 (Pfam entry).

Evidence and references

Source descriptions and links are provenance, not independent functional validation.

Evidence counts: not scored.

Curated functional assertions

No curated functional assertions supplied.

Protein sequence examples

13 verified sequence examples. FASTA

UniProtProtein / organismSequenceProvenance
A2VEC9SCO-spondin
Homo sapiens		5150 aa; version 2
UniProt 2026_03		PTM REGISTRY MIRROR
1 sibling references
O55225Otogelin
Mus musculus		2911 aa; version 3
UniProt 2026_03		PTM REGISTRY MIRROR
3 sibling references
O75443Alpha-tectorin
Homo sapiens		2155 aa; version 3
UniProt 2026_03		PTM REGISTRY MIRROR
2 sibling references
P04275von Willebrand factor
Homo sapiens		2813 aa; version 4
UniProt 2026_03		PTM REGISTRY MIRROR
3 sibling references
Q02817Mucin-2
Homo sapiens		5289 aa; version 3
UniProt 2026_03		UNIPROT FETCH
1 sibling references
Q3ZCN5Otogelin-like protein
Homo sapiens		2353 aa; version 6
UniProt 2026_03		PTM REGISTRY MIRROR
2 sibling references
Q6ZRI0Otogelin
Homo sapiens		2925 aa; version 3
UniProt 2026_03		PTM REGISTRY MIRROR
3 sibling references
Q7Z5P9Mucin-19
Homo sapiens		8384 aa; version 3
UniProt 2026_03		UNIPROT FETCH
1 sibling references
Q8CJ69BMP-binding endothelial regulator protein
Mus musculus		685 aa; version 1
UniProt 2026_03		PTM REGISTRY MIRROR
1 sibling references
Q8N8U9BMP-binding endothelial regulator protein
Homo sapiens		685 aa; version 3
UniProt 2026_03		PTM REGISTRY MIRROR
2 sibling references

First 10 shown; the FASTA and family JSON contain all examples.

Pfam membership is not functional evidence. Whole-protein sequences do not establish domain boundaries. A coverage gap here is not absence from UniProt.

Sequences and metadata: UniProt Consortium, CC BY 4.0.

Domain matches

No residue-level domain match evidence is available in this build. Structure and AlphaFold counters do not supply coordinates or establish function.

Snapshot counters

proteins
17,796
matches
45,563
proteomes
1,150
taxa
3,948
structures
36
alphafold models
8,017
domain architectures
3,699

Classification basis

pfam previous unknown name

No scoring reasons supplied.

Related Mech records

This family joined the worklist after the frozen cross-Mech scan, so other Mechs were not searched for it. Missing links here are not evidence that other Mechs lack it; rows shown come from mentions of a former DUF/UPF name.

No cross-Mech examples are present in the supplied snapshot.

Curation history and reviews

No retained curation events supplied.

No retained review supplied.

Record source

data/families/PF08742.yaml
Family YAML in this build

Download this family (JSON)

Status and evidence

Seed status
A name-based classification of frozen InterPro/Pfam metadata. UNKNOWN CANDIDATE means the metadata explicitly says the function is unknown. KNOWN HISTORICAL DUF means a DUF name matched without that wording; this heuristic is not proof of a known function and does not establish experimental characterization. EX DUF means Pfam renamed the family away from a DUF/UPF name, as recorded in Pfam's previous identifiers; a rename usually follows published work on some members but is naming history, not proof of function for every member. Some EX DUF families' current names or descriptions still say the function is unknown; their classification basis lists this, and scoring does not treat them as characterized. FALSE POSITIVE TEXT HIT means the naming rules did not match.
Characterization
A separate evidence-scoring result. UNSCORED means no score has been calculated; it is not evidence that the family lacks a known function. Missing scores are not negative evidence. PARTIALLY CHARACTERIZED has partial support; KNOWN HISTORICAL DUF can inherit the seed label or reflect a known-function signal. Neither label implies experimental validation.
Evidence counts
Source-specific signals, not unique proteins, publications, or confidence scores. Known counts Rhea reactions and experimentally supported GO molecular-function annotations. Partial counts functional/domain assignments. Context counts structural, environmental, orthology, interaction and neighborhood signals; context alone does not assign function. Repeated annotations may not be independent.
Curation status
Reported separately from seed classification and characterization. SNAPSHOT ONLY means no curated metadata was supplied for this build. SEEDED denotes a source-derived record, not an expert-reviewed functional claim.
Missing counts
Not available means the source did not supply that counter. A zero is a reported count. Not scored means evidence counts are unavailable.