DUFMech

All families / PF10629

PF10629: CMI2B-like

Ciliary microtubule inner protein 2B-like

Curation status
SEEDED
Seed status
EX DUF
Characterization
UNSCORED

Grounding

PF10629: Ciliary microtubule inner protein 2B-like
IPR018902: integrated entry for Ciliary microtubule inner protein 2B-like

Source description

This family represents a domain found in human Ciliary microtubule inner protein 2B (CMI2B) and similar proteins from eukaryotes. CMI2B is a microtubule inner proteins (MIP) that form part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating [InterPro reference PUB00103594]. This domain is a tubulin-binding domain. Some proteins contain multiple copies of this domain.

Evidence and references

Source descriptions and links are provenance, not independent functional validation.

Evidence counts: not scored.

Curated functional assertions

No curated functional assertions supplied.

Protein sequence examples

7 verified sequence examples. FASTA

UniProtProtein / organismSequenceProvenance
A2AIP0Ciliary microtubule inner protein 2B
Mus musculus		273 aa; version 1
UniProt 2026_03		UNIPROT FETCH
2 sibling references
A6NJV1Ciliary microtubule inner protein 2C
Homo sapiens		201 aa; version 1
UniProt 2026_03		UNIPROT FETCH
1 sibling references
A8MTA8Ciliary microtubule inner protein 2B
Homo sapiens		275 aa; version 1
UniProt 2026_03		UNIPROT FETCH
2 sibling references
Q6J272Ciliary microtubule inner protein 2A
Homo sapiens		317 aa; version 1
UniProt 2026_03		UNIPROT FETCH
2 sibling references
Q7JRP4CIMIP2 protein CG18335
Drosophila melanogaster		323 aa; version 1
UniProt 2026_03		UNIPROT FETCH
1 sibling references
Q9D4K5Ciliary microtubule inner protein 2A
Mus musculus		319 aa; version 1
UniProt 2026_03		UNIPROT FETCH
1 sibling references
Q9DAS2Ciliary microtubule inner protein 2C
Mus musculus		200 aa; version 1
UniProt 2026_03		UNIPROT FETCH
1 sibling references

Pfam membership is not functional evidence. Whole-protein sequences do not establish domain boundaries. A coverage gap here is not absence from UniProt.

Sequences and metadata: UniProt Consortium, CC BY 4.0.

Domain matches

No residue-level domain match evidence is available in this build. Structure and AlphaFold counters do not supply coordinates or establish function.

Snapshot counters

proteins
2,312
matches
3,198
proteomes
1,030
taxa
3,462
structures
16
alphafold models
2,008
domain architectures
30

Classification basis

pfam previous unknown name

No scoring reasons supplied.

Related Mech records

This family joined the worklist after the frozen cross-Mech scan, so other Mechs were not searched for it. Missing links here are not evidence that other Mechs lack it; rows shown come from mentions of a former DUF/UPF name.

No cross-Mech examples are present in the supplied snapshot.

Curation history and reviews

No retained curation events supplied.

No retained review supplied.

Record source

data/families/PF10629.yaml
Family YAML in this build

Download this family (JSON)

Status and evidence

Seed status
A name-based classification of frozen InterPro/Pfam metadata. UNKNOWN CANDIDATE means the metadata explicitly says the function is unknown. KNOWN HISTORICAL DUF means a DUF name matched without that wording; this heuristic is not proof of a known function and does not establish experimental characterization. EX DUF means Pfam renamed the family away from a DUF/UPF name, as recorded in Pfam's previous identifiers; a rename usually follows published work on some members but is naming history, not proof of function for every member. Some EX DUF families' current names or descriptions still say the function is unknown; their classification basis lists this, and scoring does not treat them as characterized. FALSE POSITIVE TEXT HIT means the naming rules did not match.
Characterization
A separate evidence-scoring result. UNSCORED means no score has been calculated; it is not evidence that the family lacks a known function. Missing scores are not negative evidence. PARTIALLY CHARACTERIZED has partial support; KNOWN HISTORICAL DUF can inherit the seed label or reflect a known-function signal. Neither label implies experimental validation.
Evidence counts
Source-specific signals, not unique proteins, publications, or confidence scores. Known counts Rhea reactions and experimentally supported GO molecular-function annotations. Partial counts functional/domain assignments. Context counts structural, environmental, orthology, interaction and neighborhood signals; context alone does not assign function. Repeated annotations may not be independent.
Curation status
Reported separately from seed classification and characterization. SNAPSHOT ONLY means no curated metadata was supplied for this build. SEEDED denotes a source-derived record, not an expert-reviewed functional claim.
Missing counts
Not available means the source did not supply that counter. A zero is a reported count. Not scored means evidence counts are unavailable.