DUFMech

All families / PF11835

PF11835: RRM_8

RRM-like domain

Curation status
SEEDED
Seed status
EX DUF
Characterization
UNSCORED

Grounding

PF11835: RRM-like domain
IPR021790: integrated entry for RRM-like domain

Source description

This domain is related to the RRM domains suggesting it may have an RNA-binding function.

Evidence and references

Source descriptions and links are provenance, not independent functional validation.

Evidence counts: not scored.

Curated functional assertions

No curated functional assertions supplied.

Protein sequence examples

10 verified sequence examples. FASTA

UniProtProtein / organismSequenceProvenance
O95758Polypyrimidine tract-binding protein 3
Homo sapiens		552 aa; version 2
UniProt 2026_03		PTM REGISTRY MIRROR
1 sibling references
P14866Heterogeneous nuclear ribonucleoprotein L
Homo sapiens		589 aa; version 2
UniProt 2026_03		UNIPROT FETCH
1 sibling references
P17225Polypyrimidine tract-binding protein 1
Mus musculus		555 aa; version 3
UniProt 2026_03		UNIPROT FETCH
1 sibling references
P26599Polypyrimidine tract-binding protein 1
Homo sapiens		557 aa; version 2
UniProt 2026_03		UNIPROT FETCH
1 sibling references
Q6ICX4Polypyrimidine tract-binding protein homolog 3
Arabidopsis thaliana		432 aa; version 1
UniProt 2026_03		UNIPROT FETCH
1 sibling references
Q8BHD7Polypyrimidine tract-binding protein 3
Mus musculus		523 aa; version 1
UniProt 2026_03		UNIPROT FETCH
5 sibling references
Q8R081Heterogeneous nuclear ribonucleoprotein L
Mus musculus		586 aa; version 2
UniProt 2026_03		UNIPROT FETCH
1 sibling references
Q9FGL9Polypyrimidine tract-binding protein homolog 2
Arabidopsis thaliana		429 aa; version 1
UniProt 2026_03		UNIPROT FETCH
1 sibling references
Q9MAC5Polypyrimidine tract-binding protein homolog 1
Arabidopsis thaliana		399 aa; version 1
UniProt 2026_03		UNIPROT FETCH
1 sibling references
Q9UKA9Polypyrimidine tract-binding protein 2
Homo sapiens		531 aa; version 1
UniProt 2026_03		UNIPROT FETCH
1 sibling references

Pfam membership is not functional evidence. Whole-protein sequences do not establish domain boundaries. A coverage gap here is not absence from UniProt.

Sequences and metadata: UniProt Consortium, CC BY 4.0.

Domain matches

No residue-level domain match evidence is available in this build. Structure and AlphaFold counters do not supply coordinates or establish function.

Snapshot counters

proteins
12,213
matches
12,222
proteomes
1,726
taxa
5,353
structures
9
alphafold models
10,537
domain architectures
160

Classification basis

pfam previous unknown name

No scoring reasons supplied.

Related Mech records

This family joined the worklist after the frozen cross-Mech scan, so other Mechs were not searched for it. Missing links here are not evidence that other Mechs lack it; rows shown come from mentions of a former DUF/UPF name.

No cross-Mech examples are present in the supplied snapshot.

Curation history and reviews

No retained curation events supplied.

No retained review supplied.

Record source

data/families/PF11835.yaml
Family YAML in this build

Download this family (JSON)

Status and evidence

Seed status
A name-based classification of frozen InterPro/Pfam metadata. UNKNOWN CANDIDATE means the metadata explicitly says the function is unknown. KNOWN HISTORICAL DUF means a DUF name matched without that wording; this heuristic is not proof of a known function and does not establish experimental characterization. EX DUF means Pfam renamed the family away from a DUF/UPF name, as recorded in Pfam's previous identifiers; a rename usually follows published work on some members but is naming history, not proof of function for every member. Some EX DUF families' current names or descriptions still say the function is unknown; their classification basis lists this, and scoring does not treat them as characterized. FALSE POSITIVE TEXT HIT means the naming rules did not match.
Characterization
A separate evidence-scoring result. UNSCORED means no score has been calculated; it is not evidence that the family lacks a known function. Missing scores are not negative evidence. PARTIALLY CHARACTERIZED has partial support; KNOWN HISTORICAL DUF can inherit the seed label or reflect a known-function signal. Neither label implies experimental validation.
Evidence counts
Source-specific signals, not unique proteins, publications, or confidence scores. Known counts Rhea reactions and experimentally supported GO molecular-function annotations. Partial counts functional/domain assignments. Context counts structural, environmental, orthology, interaction and neighborhood signals; context alone does not assign function. Repeated annotations may not be independent.
Curation status
Reported separately from seed classification and characterization. SNAPSHOT ONLY means no curated metadata was supplied for this build. SEEDED denotes a source-derived record, not an expert-reviewed functional claim.
Missing counts
Not available means the source did not supply that counter. A zero is a reported count. Not scored means evidence counts are unavailable.