DUFMech

All families / PF13193

PF13193: AMP-binding_C

AMP-binding enzyme C-terminal domain

Curation status
SEEDED
Seed status
EX DUF
Characterization
UNSCORED

Grounding

PF13193: AMP-binding enzyme C-terminal domain
IPR025110: integrated entry for AMP-binding enzyme C-terminal domain

Source description

This is a small domain that is found C terminal to PF00501 (Pfam entry). It has a central beta sheet core that is flanked by alpha helices.

Evidence and references

Source descriptions and links are provenance, not independent functional validation.

Evidence counts: not scored.

Curated functional assertions

No curated functional assertions supplied.

Protein sequence examples

113 verified sequence examples. FASTA

UniProtProtein / organismSequenceProvenance
A0A6G7BMN0Endopyrrole NRPS A
Mycetohabitans rhizoxinica		5199 aa; version 1
UniProt 2026_03		UNIPROT FETCH
1 sibling references
A0ABS3A5Z7AMP-binding protein
Vibrio neptunius		535 aa; version 1
UniProt 2026_03		UNIPROT FETCH
1 sibling references
A0ABS3A787Amino acid adenylation domain-containing protein
Vibrio neptunius		3992 aa; version 1
UniProt 2026_03		UNIPROT FETCH
1 sibling references
A1DN09Nonribosomal peptide synthetase anaPS
Aspergillus fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181 / WB 181)		2359 aa; version 1
UniProt 2026_03		UNIPROT FETCH
1 sibling references
A4YDR94-hydroxybutyrate--CoA ligase 2
Metallosphaera sedula (strain ATCC 51363 / DSM 5348 / JCM 9185 / NBRC 15509 / TH2)		549 aa; version 1
UniProt 2026_03		UNIPROT FETCH
1 sibling references
A4YDT14-hydroxybutyrate--CoA ligase 1
Metallosphaera sedula (strain ATCC 51363 / DSM 5348 / JCM 9185 / NBRC 15509 / TH2)		564 aa; version 1
UniProt 2026_03		UNIPROT FETCH
1 sibling references
A4YGR13-hydroxypropionyl-coenzyme A synthetase
Metallosphaera sedula (strain ATCC 51363 / DSM 5348 / JCM 9185 / NBRC 15509 / TH2)		661 aa; version 1
UniProt 2026_03		UNIPROT FETCH
1 sibling references
A6N339N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valine synthase
Penicillium chrysogenum		3791 aa; version 1
UniProt 2026_03		UNIPROT FETCH
1 sibling references
B1YBY4AMP-dependent synthetase and ligase
Pyrobaculum neutrophilum (strain DSM 2338 / JCM 9278 / NBRC 100436 / V24Sta)		629 aa; version 1
UniProt 2026_03		UNIPROT FETCH
1 sibling references
B9DGD6Acetyl-coenzyme A synthetase, chloroplastic/glyoxysomal
Arabidopsis thaliana		743 aa; version 1
UniProt 2026_03		PTM REGISTRY MIRROR
1 sibling references

First 10 shown; the FASTA and family JSON contain all examples.

Pfam membership is not functional evidence. Whole-protein sequences do not establish domain boundaries. A coverage gap here is not absence from UniProt.

Sequences and metadata: UniProt Consortium, CC BY 4.0.

Domain matches

No residue-level domain match evidence is available in this build. Structure and AlphaFold counters do not supply coordinates or establish function.

Snapshot counters

proteins
284,163
matches
317,945
proteomes
20,559
taxa
34,100
structures
297
alphafold models
168,232
domain architectures
6,661

Classification basis

pfam previous unknown name

No scoring reasons supplied.

Related Mech records

This family joined the worklist after the frozen cross-Mech scan, so other Mechs were not searched for it. Missing links here are not evidence that other Mechs lack it; rows shown come from mentions of a former DUF/UPF name.

No cross-Mech examples are present in the supplied snapshot.

Curation history and reviews

No retained curation events supplied.

No retained review supplied.

Record source

data/families/PF13193.yaml
Family YAML in this build

Download this family (JSON)

Status and evidence

Seed status
A name-based classification of frozen InterPro/Pfam metadata. UNKNOWN CANDIDATE means the metadata explicitly says the function is unknown. KNOWN HISTORICAL DUF means a DUF name matched without that wording; this heuristic is not proof of a known function and does not establish experimental characterization. EX DUF means Pfam renamed the family away from a DUF/UPF name, as recorded in Pfam's previous identifiers; a rename usually follows published work on some members but is naming history, not proof of function for every member. Some EX DUF families' current names or descriptions still say the function is unknown; their classification basis lists this, and scoring does not treat them as characterized. FALSE POSITIVE TEXT HIT means the naming rules did not match.
Characterization
A separate evidence-scoring result. UNSCORED means no score has been calculated; it is not evidence that the family lacks a known function. Missing scores are not negative evidence. PARTIALLY CHARACTERIZED has partial support; KNOWN HISTORICAL DUF can inherit the seed label or reflect a known-function signal. Neither label implies experimental validation.
Evidence counts
Source-specific signals, not unique proteins, publications, or confidence scores. Known counts Rhea reactions and experimentally supported GO molecular-function annotations. Partial counts functional/domain assignments. Context counts structural, environmental, orthology, interaction and neighborhood signals; context alone does not assign function. Repeated annotations may not be independent.
Curation status
Reported separately from seed classification and characterization. SNAPSHOT ONLY means no curated metadata was supplied for this build. SEEDED denotes a source-derived record, not an expert-reviewed functional claim.
Missing counts
Not available means the source did not supply that counter. A zero is a reported count. Not scored means evidence counts are unavailable.