DUFMech

All families / PF14703

PF14703: PHM7_cyt

Cytosolic domain of 10TM putative phosphate transporter

Curation status
SEEDED
Seed status
EX DUF
Characterization
UNSCORED

Grounding

PF14703: Cytosolic domain of 10TM putative phosphate transporter
IPR027815: integrated entry for Cytosolic domain of 10TM putative phosphate transporter

Source description

PHM7_cyt is the predicted cytosolic domain of integral membrane proteins, such as yeast PHM7 and TM63A_HUMAN TRANSMEMBRANE PROTEIN 63A, SwissProt:O94886. This domain usually precedes the 7TM region, PF02714 (Calcium-dependent channel, 7TM region, putative phosphate), and follows a RSN1_TM, PF13967 (Pfam entry). Fold recognition programs consistently and with high significance predict this domain to be distantly homologous to RNA binding proteins from the RRM clan.

Evidence and references

Source descriptions and links are provenance, not independent functional validation.

Evidence counts: not scored.

Curated functional assertions

No curated functional assertions supplied.

Protein sequence examples

11 verified sequence examples. FASTA

UniProtProtein / organismSequenceProvenance
B5TYT3Hyperosmolality-gated Ca2+ permeable channel 1.3
Arabidopsis thaliana		771 aa; version 1
UniProt 2026_03		UNIPROT FETCH
6 sibling references
O94886Mechanosensitive cation channel TMEM63A
Homo sapiens		807 aa; version 3
UniProt 2026_03		PTM REGISTRY MIRROR
9 sibling references
Q03516Uncharacterized protein RSN1
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)		953 aa; version 1
UniProt 2026_03		UNIPROT FETCH
2 sibling references
Q12252Phosphate metabolism protein 7
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)		991 aa; version 1
UniProt 2026_03		UNIPROT FETCH
2 sibling references
Q3TWI9Mechanosensitive cation channel TMEM63B
Mus musculus		832 aa; version 1
UniProt 2026_03		UNIPROT FETCH
12 sibling references
Q5T3F8Mechanosensitive cation channel TMEM63B
Homo sapiens		832 aa; version 1
UniProt 2026_03		UNIPROT FETCH
12 sibling references
Q6NP91Mechanosensitive cation channel Tmem63
Drosophila melanogaster		760 aa; version 1
UniProt 2026_03		UNIPROT FETCH
10 sibling references
Q91YT8Mechanosensitive cation channel TMEM63A
Mus musculus		804 aa; version 1
UniProt 2026_03		UNIPROT FETCH
1 sibling references
Q9C8G5Hyperosmolality-gated Ca2+ permeable channel 3.1
Arabidopsis thaliana		724 aa; version 1
UniProt 2026_03		UNIPROT FETCH
6 sibling references
Q9FVQ5Hyperosmolality-gated Ca2+ permeable channel 1.8
Arabidopsis thaliana		806 aa; version 1
UniProt 2026_03		UNIPROT FETCH
6 sibling references

First 10 shown; the FASTA and family JSON contain all examples.

Pfam membership is not functional evidence. Whole-protein sequences do not establish domain boundaries. A coverage gap here is not absence from UniProt.

Sequences and metadata: UniProt Consortium, CC BY 4.0.

Domain matches

No residue-level domain match evidence is available in this build. Structure and AlphaFold counters do not supply coordinates or establish function.

Snapshot counters

proteins
20,870
matches
22,064
proteomes
3,245
taxa
8,562
structures
41
alphafold models
16,802
domain architectures
327

Classification basis

pfam previous unknown name

No scoring reasons supplied.

Related Mech records

This family joined the worklist after the frozen cross-Mech scan, so other Mechs were not searched for it. Missing links here are not evidence that other Mechs lack it; rows shown come from mentions of a former DUF/UPF name.

No cross-Mech examples are present in the supplied snapshot.

Curation history and reviews

No retained curation events supplied.

No retained review supplied.

Record source

data/families/PF14703.yaml
Family YAML in this build

Download this family (JSON)

Status and evidence

Seed status
A name-based classification of frozen InterPro/Pfam metadata. UNKNOWN CANDIDATE means the metadata explicitly says the function is unknown. KNOWN HISTORICAL DUF means a DUF name matched without that wording; this heuristic is not proof of a known function and does not establish experimental characterization. EX DUF means Pfam renamed the family away from a DUF/UPF name, as recorded in Pfam's previous identifiers; a rename usually follows published work on some members but is naming history, not proof of function for every member. Some EX DUF families' current names or descriptions still say the function is unknown; their classification basis lists this, and scoring does not treat them as characterized. FALSE POSITIVE TEXT HIT means the naming rules did not match.
Characterization
A separate evidence-scoring result. UNSCORED means no score has been calculated; it is not evidence that the family lacks a known function. Missing scores are not negative evidence. PARTIALLY CHARACTERIZED has partial support; KNOWN HISTORICAL DUF can inherit the seed label or reflect a known-function signal. Neither label implies experimental validation.
Evidence counts
Source-specific signals, not unique proteins, publications, or confidence scores. Known counts Rhea reactions and experimentally supported GO molecular-function annotations. Partial counts functional/domain assignments. Context counts structural, environmental, orthology, interaction and neighborhood signals; context alone does not assign function. Repeated annotations may not be independent.
Curation status
Reported separately from seed classification and characterization. SNAPSHOT ONLY means no curated metadata was supplied for this build. SEEDED denotes a source-derived record, not an expert-reviewed functional claim.
Missing counts
Not available means the source did not supply that counter. A zero is a reported count. Not scored means evidence counts are unavailable.