aetokthonotoxin
CHEBI:167886 EXACT SEEDED
A bromoindole that is 2,3,5-tribromo-1H-indole which is substituted by a 5,7-dibromo-3-cyano-1H-indol-2-yl group at position 1. It is a biindole alkaloid isolated from the cyanobacterium Aetokthonos hydrillicola and causes vacuolar myelinopathy in bald eagles.
Structure
| Standard InChIKey | JXJDQKCOJBAPQM-UHFFFAOYSA-N |
|---|---|
| SMILES | N#CC1=C(N2C(Br)=C(Br)C3=C2C=CC(Br)=C3)NC4=C(Br)C=C(Br)C=C41 |
| Stereochemistry | fully defined |
| Cross-references | cyanometdb:CyanoMetDB_2448 |
Filing pathway
Alkaloids — computed by NPClassifier npclassifier.gnps2.org@2026-09-07, which is why it is pinned rather than recomputed. The gene cluster's asserted class is other, from MIBiG.
Producer organisms 1
A claim that this taxon makes the compound. The basis says what the evidence addressed — a knockout and a database assertion are not the same claim.
| Taxon | Basis | Cluster | Evidence |
|---|---|---|---|
| Aetokthonos hydrillicola Thurmond2011 NCBITaxon:2712845 |
SOURCE_ASSERTION | mibig:BGC0002643 | PMID:33766860 |
Occurrences 3
Somebody found the compound in this organism and cited it. That is not a claim that the organism makes it, and nothing here promotes one to the other.
| Taxon | Source | Reference |
|---|---|---|
| Aetokthonos hydrillicola NCBITaxon:1550245 |
LOTUS | DOI:10.1126/SCIENCE.AAX9050 |
| Aetokthonos hydrillicola NCBITaxon:1550245 |
CYANOMETDB | DOI:10.1126/science.aax9050 |
| Aetokthonos hydrillicola NCBITaxon:1550245 |
CHEBI | PMID:33766860 |
Biosynthetic gene clusters 1
| Accession | Host | Locus evidence | Genome |
|---|---|---|---|
| mibig:BGC0002643 | Aetokthonos hydrillicola Thurmond2011 NCBITaxon:2712845 |
CLUSTER_DEMONSTRATED | genbank:MT225528.1 |
A locus claim and a taxon claim are different questions. Heterologous expression settles the first and leaves the second where the isolation report left it.
Provenance
| Source concept | Source | Version |
|---|---|---|
| BGC0002643 | MIBIG | 2 |
| CHEBI:167886 | CHEBI | 3-star |
This page is generated from data/natural_products/alkaloids/aetokthonotoxin.yaml, which is generated from the committed inventories. Neither is edited by hand.