NaturalProductMech

Protein sequence map (pLM)

763 unique proteins across 303 natural product records (4541 protein–record mentions), embedded with facebook/esm2_t33_650M_UR50D (revision 08e4846e537177426273712802403f7ba8261b6c, 1280-d mean-pooled residue representations) and projected to 2D with PaCMAP (n_neighbors=10, mean-centred cosine prep).

Positions depend only on amino-acid sequence via the protein language model facebook/esm2_t33_650M_UR50D. Biosynthetic filing pathways, enzymatic vs. target roles, and producer taxonomy are layered on as colors and filters without influencing the coordinates.

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