altemicidin

naturalproductmech:mibig-a58ee03ee4 MINTED SEEDED

Grounding review: No 3-star ChEBI entry shares this structure, so the record keeps a content-hashed identifier.

What these status tags mean

Curation status describes a workflow state. SEEDED means the record entered through the source-seeding workflow; it does not imply that no later curation occurred. PROPOSED marks an addition awaiting review; REVIEWED records curator sign-off on identity, structure, filing class and producer claims; DEPRECATED retains a superseded or out-of-scope record. These are workflow decisions, not independently verified human review. Agent-assisted contributions may appear in the record history.

Grounding describes the identifier mapping: EXACT uses an ontology identity asserted by the source; MINTED keeps a local identifier when no defensible ontology identity is available; REVIEW_NEEDED flags an exact structure whose ontology identity needs adjudication. The grounding note retains any unresolved alternatives. These tags do not establish the strength of producer or activity evidence.

Structure

Standard InChIKey	VZRFZUPFQKSXPV-VPFIQFBESA-N
SMILES	CN1C[C@@H]2[C@@H](C[C@@H]([C@]2(C(=O)O)NC(=O)CS(=O)(=O)N)O)C(=C1)C(=O)N
Stereochemistry	fully defined
Cross-references	pubchem:11036174

Filing pathway

Alkaloids — computed by NPClassifier npclassifier.gnps2.org@2026-09-07, which is why it is pinned rather than recomputed. The gene cluster's asserted class is other, from MIBiG.

Producer organisms 1

A claim that this taxon makes the compound. The basis says what the evidence addressed — a knockout and a database assertion are not the same claim.

Taxon	Basis	Cluster	Evidence
Streptomyces sp. NCBITaxon:1931	SOURCE_ASSERTION	mibig:BGC0001925	PMID:30643149

Occurrences 2

Somebody found the compound in this organism and cited it. That is not a claim that the organism makes it, and nothing here promotes one to the other.

Taxon	Source	Reference
Streptomyces sioyaensis NCBITaxon:67364	LOTUS	DOI:10.7164/ANTIBIOTICS.42.1556
Streptomyces sioyaensis NCBITaxon:67364	LOTUS	DOI:10.7164/ANTIBIOTICS.42.1562

Biosynthetic gene clusters 1

Accession	Host	Locus evidence	Genome
mibig:BGC0001925	Streptomyces sp. NCBITaxon:1931	CLUSTER_UNSTATED	genbank:LC420052.1

A locus claim and a taxon claim are different questions. Heterologous expression settles the first and leaves the second where the isolation report left it.

Mechanism & Biosynthesis Overview

Causal graph — biosynthesis 6 nodes, 5 edges

Database-annotated early scaffold formation by native SbzP/Q from Streptomyces sp. NCIMB 40513. Intermediate numbers follow UniProt annotations. This partial schematic omits cofactors/byproducts as nodes; it is not a balanced reaction or a full pathway reconstitution.

Subject	Predicate	Object	Evidence
NAD(+)	is_annotated_substrate_of	SbzP (NCIMB 40513 native reference)	https://www.uniprot.org/uniprotkb/P0DY52/entry https://www.ncbi.nlm.nih.gov/protein/BBG06565.1 reference https://www.uniprot.org/uniprotkb/P0DY52/entry evidence type DATABASE_ASSERTION retrieved on 2026-10-11 notes NAD(+) supplies the scaffold precursor rather than acting solely as a redox cofactor. Reviewed UniProtKB entry version 3, sequence version 1; annotation evidence, not an independently inspected primary experiment. snippet uses S-adenosyl-L-methionine and NAD(+) to form a 6-azatetrahydroindane scaffold reference https://www.ncbi.nlm.nih.gov/protein/BBG06565.1 evidence type CURATOR_INFERENCE retrieved on 2026-10-11 notes Native reference: sbzP, 523 aa, Streptomyces sp. NCIMB 40513 (NCBITaxon:1931), reverse-strand LC420052.1:16668..18239. CDS-aware genomic translation, deposited translation, GenPept and UniProt sequences agree exactly without ambiguous residues. This does not establish the sequence of a tagged, fused, truncated or mutated experimental construct.
S-adenosyl-L-methionine	is_annotated_substrate_of	SbzP (NCIMB 40513 native reference)	https://www.uniprot.org/uniprotkb/P0DY52/entry reference https://www.uniprot.org/uniprotkb/P0DY52/entry evidence type DATABASE_ASSERTION retrieved on 2026-10-11 notes SAM is the annotated aminocarboxypropyl donor in scaffold formation. Reviewed UniProtKB entry version 3, sequence version 1; annotation evidence, not an independently inspected primary experiment.
SbzP (NCIMB 40513 native reference)	is_annotated_to_produce	Altemicidin intermediate 1 (UniProt annotation)	https://www.uniprot.org/uniprotkb/P0DY52/entry reference https://www.uniprot.org/uniprotkb/P0DY52/entry evidence type DATABASE_ASSERTION retrieved on 2026-10-11 notes UniProt annotates formation of the 6-azatetrahydroindane scaffold intermediate 1, with methylthioadenosine and protons as byproducts. Reviewed UniProtKB entry version 3, sequence version 1; annotation evidence, not an independently inspected primary experiment.
Altemicidin intermediate 1 (UniProt annotation)	is_annotated_substrate_of	SbzQ (NCIMB 40513 native reference)	https://www.uniprot.org/uniprotkb/P0DY53/entry https://www.ncbi.nlm.nih.gov/protein/BBG06566.1 reference https://www.uniprot.org/uniprotkb/P0DY53/entry evidence type DATABASE_ASSERTION retrieved on 2026-10-11 notes SbzQ is annotated to hydroxylate intermediate 1; oxygen and 2-oxoglutarate are cosubstrates. Reviewed UniProtKB entry version 3, sequence version 1; annotation evidence, not an independently inspected primary experiment. snippet leading to the formation of altemicidin intermediate 2 reference https://www.ncbi.nlm.nih.gov/protein/BBG06566.1 evidence type CURATOR_INFERENCE retrieved on 2026-10-11 notes Native reference: sbzQ, 304 aa, Streptomyces sp. NCIMB 40513 (NCBITaxon:1931), reverse-strand LC420052.1:18324..19238. CDS-aware genomic translation, deposited translation, GenPept and UniProt sequences agree exactly without ambiguous residues. This does not establish the sequence of a tagged, fused, truncated or mutated experimental construct.
SbzQ (NCIMB 40513 native reference)	is_annotated_to_produce	Altemicidin intermediate 2 (UniProt annotation)	https://www.uniprot.org/uniprotkb/P0DY53/entry reference https://www.uniprot.org/uniprotkb/P0DY53/entry evidence type DATABASE_ASSERTION retrieved on 2026-10-11 notes The annotated hydroxylation yields intermediate 2, succinate and carbon dioxide. No new exact chemical identifier or experimental construct is assigned. Reviewed UniProtKB entry version 3, sequence version 1; annotation evidence, not an independently inspected primary experiment.

Every edge carries its own citation; an uncited edge is refused by the corpus tests.

Causal graph — biosynthesis 11 nodes, 10 edges

Database-annotated sulfamoyl precursor synthesis, carrier loading and transfer in altemicidin biosynthesis. SbzG and SbzK nodes denote native carrier references, not stand-alone enzymes or permanently acylated proteins. Carrier loading includes in-vitro database annotations. Only SbzG donor use is drawn for SbzI; the probable SbzK handoff is not asserted. No stable complex, stoichiometry or in-vivo carrier interchangeability is claimed.

Subject	Predicate	Object	Evidence
L-Cysteine	is_annotated_substrate_of	SbzM (NCIMB 40513 native reference)	https://www.uniprot.org/uniprotkb/P0DY49/entry https://www.ncbi.nlm.nih.gov/protein/BBG06562.1 reference https://www.uniprot.org/uniprotkb/P0DY49/entry evidence type DATABASE_ASSERTION retrieved on 2026-10-11 notes SbzM is annotated to act on L-cysteine through oxidation/decarboxylation and rearrangement; the transient species are not separately grounded here. Reviewed UniProtKB entry version 3, sequence version 1; annotation evidence, not an independently inspected primary experiment. snippet oxidation and decarboxylation of L-cysteine reference https://www.ncbi.nlm.nih.gov/protein/BBG06562.1 evidence type CURATOR_INFERENCE retrieved on 2026-10-11 notes Native reference: sbzM, 228 aa, Streptomyces sp. NCIMB 40513 (NCBITaxon:1931), reverse-strand LC420052.1:14000..14686. CDS-aware genomic translation, deposited translation, GenPept and UniProt sequences agree exactly without ambiguous residues. This does not establish the sequence of a tagged, fused, truncated or mutated experimental construct.
SbzM (NCIMB 40513 native reference)	is_annotated_to_produce	2-Oxoethane-1-sulfonamide	https://www.uniprot.org/uniprotkb/P0DY49/entry reference https://www.uniprot.org/uniprotkb/P0DY49/entry evidence type DATABASE_ASSERTION retrieved on 2026-10-11 notes The annotated net conversion yields 2-oxoethane-1-sulfonamide, with oxygen consumption and carbon dioxide/water byproducts. No individual microscopic step or metal specificity is newly established. Reviewed UniProtKB entry version 3, sequence version 1; annotation evidence, not an independently inspected primary experiment.
2-Oxoethane-1-sulfonamide	is_annotated_substrate_of	SbzJ (NCIMB 40513 native reference)	https://www.uniprot.org/uniprotkb/P0DY46/entry https://www.ncbi.nlm.nih.gov/protein/BBG06559.1 reference https://www.uniprot.org/uniprotkb/P0DY46/entry evidence type DATABASE_ASSERTION retrieved on 2026-10-11 notes UniProt annotates aldehyde oxidation by SbzJ with NAD(+) and water. Reviewed UniProtKB entry version 3, sequence version 1; annotation evidence, not an independently inspected primary experiment. snippet conversion of 2-oxoethane-1-sulfonamide to 2-sulfamoylacetate reference https://www.ncbi.nlm.nih.gov/protein/BBG06559.1 evidence type CURATOR_INFERENCE retrieved on 2026-10-11 notes Native reference: sbzJ, 464 aa, Streptomyces sp. NCIMB 40513 (NCBITaxon:1931), reverse-strand LC420052.1:10630..12024. CDS-aware genomic translation, deposited translation, GenPept and UniProt sequences agree exactly without ambiguous residues. This does not establish the sequence of a tagged, fused, truncated or mutated experimental construct.
SbzJ (NCIMB 40513 native reference)	is_annotated_to_produce	2-Sulfamoylacetate	https://www.uniprot.org/uniprotkb/P0DY46/entry reference https://www.uniprot.org/uniprotkb/P0DY46/entry evidence type DATABASE_ASSERTION retrieved on 2026-10-11 notes The annotated oxidation yields 2-sulfamoylacetate with NADH and protons. Reviewed UniProtKB entry version 3, sequence version 1; annotation evidence, not an independently inspected primary experiment.
2-Sulfamoylacetate	is_annotated_substrate_of	SbzL (NCIMB 40513 native reference)	https://www.uniprot.org/uniprotkb/P0DY48/entry https://www.ncbi.nlm.nih.gov/protein/BBG06561.1 reference https://www.uniprot.org/uniprotkb/P0DY48/entry evidence type DATABASE_ASSERTION retrieved on 2026-10-11 notes SbzL is annotated to activate 2-sulfamoylacetate for ATP-dependent loading onto a holo carrier; AMP and diphosphate are omitted byproducts. Reviewed UniProtKB entry version 3, sequence version 1; annotation evidence, not an independently inspected primary experiment. snippet ATP-dependent loading of 2-sulfamoylacetate onto an acyl carrier protein reference https://www.ncbi.nlm.nih.gov/protein/BBG06561.1 evidence type CURATOR_INFERENCE retrieved on 2026-10-11 notes Native reference: sbzL, 559 aa, Streptomyces sp. NCIMB 40513 (NCBITaxon:1931), reverse-strand LC420052.1:12317..13996. CDS-aware genomic translation, deposited translation, GenPept and UniProt sequences agree exactly without ambiguous residues. This does not establish the sequence of a tagged, fused, truncated or mutated experimental construct.
SbzL (NCIMB 40513 native reference)	is_annotated_to_load_2_sulfamoylacetate_onto	SbzG (NCIMB 40513 native reference)	https://www.uniprot.org/uniprotkb/P0DY48/entry https://www.uniprot.org/uniprotkb/P0DY36/entry https://www.ncbi.nlm.nih.gov/protein/BBG06556.1 reference https://www.uniprot.org/uniprotkb/P0DY48/entry evidence type DATABASE_ASSERTION retrieved on 2026-10-11 notes SbzG is an annotated in-vitro carrier acceptor for SbzL. This edge concerns acyl loading of the holo form, not a permanent protein-protein complex. Reviewed UniProtKB entry version 3, sequence version 1; annotation evidence, not an independently inspected primary experiment. reference https://www.uniprot.org/uniprotkb/P0DY36/entry evidence type DATABASE_ASSERTION retrieved on 2026-10-11 notes SbzG is an annotated in-vitro carrier acceptor for SbzL. This edge concerns acyl loading of the holo form, not a permanent protein-protein complex. Reviewed UniProtKB entry version 3, sequence version 1; annotation evidence, not an independently inspected primary experiment. snippet It can transfer 2-sulfamoylacetate to SbzI reference https://www.ncbi.nlm.nih.gov/protein/BBG06556.1 evidence type CURATOR_INFERENCE retrieved on 2026-10-11 notes Native reference: sbzG, 85 aa, Streptomyces sp. NCIMB 40513 (NCBITaxon:1931), reverse-strand LC420052.1:8750..9007. CDS-aware genomic translation, deposited translation, GenPept and UniProt sequences agree exactly without ambiguous residues. This does not establish the sequence of a tagged, fused, truncated or mutated experimental construct.
SbzL (NCIMB 40513 native reference)	is_annotated_to_load_2_sulfamoylacetate_onto	SbzK (NCIMB 40513 native reference)	https://www.uniprot.org/uniprotkb/P0DY48/entry https://www.uniprot.org/uniprotkb/P0DY47/entry https://www.ncbi.nlm.nih.gov/protein/BBG06560.1 reference https://www.uniprot.org/uniprotkb/P0DY48/entry evidence type DATABASE_ASSERTION retrieved on 2026-10-11 notes SbzK is an annotated in-vitro carrier acceptor for SbzL. This does not prove native redundancy with SbzG or direct donor use by SbzI. Reviewed UniProtKB entry version 3, sequence version 1; annotation evidence, not an independently inspected primary experiment. reference https://www.uniprot.org/uniprotkb/P0DY47/entry evidence type DATABASE_ASSERTION retrieved on 2026-10-11 notes SbzK is an annotated in-vitro carrier acceptor for SbzL. This does not prove native redundancy with SbzG or direct donor use by SbzI. Reviewed UniProtKB entry version 3, sequence version 1; annotation evidence, not an independently inspected primary experiment. snippet In vitro, can accept 2-sulfamoylacetate from SbzL reference https://www.ncbi.nlm.nih.gov/protein/BBG06560.1 evidence type CURATOR_INFERENCE retrieved on 2026-10-11 notes Native reference: sbzK, 93 aa, Streptomyces sp. NCIMB 40513 (NCBITaxon:1931), reverse-strand LC420052.1:12039..12320. CDS-aware genomic translation, deposited translation, GenPept and UniProt sequences agree exactly without ambiguous residues. This does not establish the sequence of a tagged, fused, truncated or mutated experimental construct.
SbzG (NCIMB 40513 native reference)	is_annotated_acyl_donor_carrier_for	SbzI (NCIMB 40513 native reference)	https://www.uniprot.org/uniprotkb/P0DY36/entry https://www.uniprot.org/uniprotkb/P0DY45/entry https://www.ncbi.nlm.nih.gov/protein/BBG06558.1 reference https://www.uniprot.org/uniprotkb/P0DY36/entry evidence type DATABASE_ASSERTION retrieved on 2026-10-11 notes The loaded SbzG carrier supplies the 2-sulfamoylacetyl group to SbzI. UniProt marks SbzK acceptance only as probable, so no SbzK-to-SbzI edge is added. Native reference mapping does not resolve the 2024 fused constructs. Reviewed UniProtKB entry version 3, sequence version 1; annotation evidence, not an independently inspected primary experiment. reference https://www.uniprot.org/uniprotkb/P0DY45/entry evidence type DATABASE_ASSERTION retrieved on 2026-10-11 notes The loaded SbzG carrier supplies the 2-sulfamoylacetyl group to SbzI. UniProt marks SbzK acceptance only as probable, so no SbzK-to-SbzI edge is added. Native reference mapping does not resolve the 2024 fused constructs. Reviewed UniProtKB entry version 3, sequence version 1; annotation evidence, not an independently inspected primary experiment. snippet probably also from SbzK reference https://www.ncbi.nlm.nih.gov/protein/BBG06558.1 evidence type CURATOR_INFERENCE retrieved on 2026-10-11 notes Native reference: sbzI, 188 aa, Streptomyces sp. NCIMB 40513 (NCBITaxon:1931), reverse-strand LC420052.1:10061..10627. CDS-aware genomic translation, deposited translation, GenPept and UniProt sequences agree exactly without ambiguous residues. This does not establish the sequence of a tagged, fused, truncated or mutated experimental construct.
Altemicidin intermediate 2 (UniProt annotation)	is_annotated_substrate_of	SbzI (NCIMB 40513 native reference)	https://www.uniprot.org/uniprotkb/P0DY45/entry reference https://www.uniprot.org/uniprotkb/P0DY45/entry evidence type DATABASE_ASSERTION retrieved on 2026-10-11 notes The intermediate-2 amino group is the annotated acceptor of the carrier-borne 2-sulfamoylacetyl group. Reviewed UniProtKB entry version 3, sequence version 1; annotation evidence, not an independently inspected primary experiment.
SbzI (NCIMB 40513 native reference)	is_annotated_to_produce	Altemicidin intermediate 3 (UniProt annotation)	https://www.uniprot.org/uniprotkb/P0DY45/entry reference https://www.uniprot.org/uniprotkb/P0DY45/entry evidence type DATABASE_ASSERTION retrieved on 2026-10-11 notes The annotated transfer yields intermediate 3 and releases holo carrier. This is not direct formation of altemicidin. Reviewed UniProtKB entry version 3, sequence version 1; annotation evidence, not an independently inspected primary experiment.

Every edge carries its own citation; an uncited edge is refused by the corpus tests.

Causal graph — biosynthesis 5 nodes, 4 edges

Database-annotated late reduction and N-methylation yielding the altemicidin scaffold. No edge connects intermediate 3 to didehydrodemethylaltemicidin: the intervening chemistry is unresolved in the adopted evidence. The owner denotes the neutral compound; this schematic does not assert a balanced, protonation-specific Rhea reaction.

Subject	Predicate	Object	Evidence
Didehydrodemethylaltemicidin	is_annotated_substrate_of	SbzF (NCIMB 40513 native reference)	https://www.uniprot.org/uniprotkb/P0DY35/entry https://www.ncbi.nlm.nih.gov/protein/BBG06555.1 reference https://www.uniprot.org/uniprotkb/P0DY35/entry evidence type DATABASE_ASSERTION retrieved on 2026-10-11 notes SbzF is annotated to reduce didehydrodemethylaltemicidin with reduced coenzyme F420. A particular F420 glutamate-chain length is not assigned. Reviewed UniProtKB entry version 3, sequence version 1; annotation evidence, not an independently inspected primary experiment. snippet conversion of didehydrodemethylaltemicidin to demethylaltemicidin reference https://www.ncbi.nlm.nih.gov/protein/BBG06555.1 evidence type CURATOR_INFERENCE retrieved on 2026-10-11 notes Native reference: sbzF, 320 aa, Streptomyces sp. NCIMB 40513 (NCBITaxon:1931), reverse-strand LC420052.1:7743..8705. CDS-aware genomic translation, deposited translation, GenPept and UniProt sequences agree exactly without ambiguous residues. This does not establish the sequence of a tagged, fused, truncated or mutated experimental construct.
SbzF (NCIMB 40513 native reference)	is_annotated_to_produce	Demethylaltemicidin	https://www.uniprot.org/uniprotkb/P0DY35/entry reference https://www.uniprot.org/uniprotkb/P0DY35/entry evidence type DATABASE_ASSERTION retrieved on 2026-10-11 notes The annotated reduction yields demethylaltemicidin with oxidized F420 and a proton. Reviewed UniProtKB entry version 3, sequence version 1; annotation evidence, not an independently inspected primary experiment.
Demethylaltemicidin	is_annotated_substrate_of	SbzE (NCIMB 40513 native reference)	https://www.uniprot.org/uniprotkb/P0DY34/entry https://www.ncbi.nlm.nih.gov/protein/BBG06554.1 reference https://www.uniprot.org/uniprotkb/P0DY34/entry evidence type DATABASE_ASSERTION retrieved on 2026-10-11 notes SbzE is annotated to methylate demethylaltemicidin using SAM. Reviewed UniProtKB entry version 3, sequence version 1; annotation evidence, not an independently inspected primary experiment. snippet conversion of demethylaltemicidin to altemicidin reference https://www.ncbi.nlm.nih.gov/protein/BBG06554.1 evidence type CURATOR_INFERENCE retrieved on 2026-10-11 notes Native reference: sbzE, 260 aa, Streptomyces sp. NCIMB 40513 (NCBITaxon:1931), reverse-strand LC420052.1:6905..7687. CDS-aware genomic translation, deposited translation, GenPept and UniProt sequences agree exactly without ambiguous residues. This does not establish the sequence of a tagged, fused, truncated or mutated experimental construct.
SbzE (NCIMB 40513 native reference)	is_annotated_to_produce	Altemicidin	https://www.uniprot.org/uniprotkb/P0DY34/entry reference https://www.uniprot.org/uniprotkb/P0DY34/entry evidence type DATABASE_ASSERTION retrieved on 2026-10-11 notes UniProt annotates altemicidin formation with S-adenosylhomocysteine and a proton. This is the altemicidin scaffold, not its later isoleucylated SB-203207 or SB-203208 congeners. Reviewed UniProtKB entry version 3, sequence version 1; annotation evidence, not an independently inspected primary experiment.

Every edge carries its own citation; an uncited edge is refused by the corpus tests.

Causal graph — biosynthesis 5 nodes, 4 edges

Database-annotated participation of native SbzH/N/O in altemicidin biosynthesis, without an individual catalytic assignment, fixed reaction order or complex claim. The process node is not a protein complex and does not fill the unresolved intermediate-3-to-late-tailoring connection.

Subject	Predicate	Object	Evidence
SbzH (NCIMB 40513 native reference)	is_annotated_participant_in	Altemicidin biosynthesis (annotated participation)	https://www.uniprot.org/uniprotkb/P0DY37/entry https://www.ncbi.nlm.nih.gov/protein/BBG06557.1 reference https://www.uniprot.org/uniprotkb/P0DY37/entry evidence type DATABASE_ASSERTION retrieved on 2026-10-11 notes UniProt annotates SbzH involvement in altemicidin biosynthesis. This does not assign its individual reaction, prove an H/N/O complex or identify an assay construct. Reviewed UniProtKB entry version 3, sequence version 1; annotation evidence, not an independently inspected primary experiment. snippet Involved in the biosynthesis of the sulfonamide antibiotics altemicidin reference https://www.ncbi.nlm.nih.gov/protein/BBG06557.1 evidence type CURATOR_INFERENCE retrieved on 2026-10-11 notes Native reference: sbzH, 334 aa, Streptomyces sp. NCIMB 40513 (NCBITaxon:1931), reverse-strand LC420052.1:9057..10061. CDS-aware genomic translation, deposited translation, GenPept and UniProt sequences agree exactly without ambiguous residues. This does not establish the sequence of a tagged, fused, truncated or mutated experimental construct.
SbzN (NCIMB 40513 native reference)	is_annotated_participant_in	Altemicidin biosynthesis (annotated participation)	https://www.uniprot.org/uniprotkb/P0DY50/entry https://www.ncbi.nlm.nih.gov/protein/BBG06563.1 reference https://www.uniprot.org/uniprotkb/P0DY50/entry evidence type DATABASE_ASSERTION retrieved on 2026-10-11 notes UniProt annotates SbzN involvement in altemicidin biosynthesis. This does not assign its individual reaction, prove an H/N/O complex or identify an assay construct. Reviewed UniProtKB entry version 3, sequence version 1; annotation evidence, not an independently inspected primary experiment. snippet Involved in the biosynthesis of the sulfonamide antibiotics altemicidin reference https://www.ncbi.nlm.nih.gov/protein/BBG06563.1 evidence type CURATOR_INFERENCE retrieved on 2026-10-11 notes Native reference: sbzN, 385 aa, Streptomyces sp. NCIMB 40513 (NCBITaxon:1931), reverse-strand LC420052.1:14704..15861. CDS-aware genomic translation, deposited translation, GenPept and UniProt sequences agree exactly without ambiguous residues. This does not establish the sequence of a tagged, fused, truncated or mutated experimental construct.
SbzO (NCIMB 40513 native reference)	is_annotated_participant_in	Altemicidin biosynthesis (annotated participation)	https://www.uniprot.org/uniprotkb/P0DY51/entry https://www.ncbi.nlm.nih.gov/protein/BBG06564.1 reference https://www.uniprot.org/uniprotkb/P0DY51/entry evidence type DATABASE_ASSERTION retrieved on 2026-10-11 notes UniProt annotates SbzO involvement in altemicidin biosynthesis. This does not assign its individual reaction, prove an H/N/O complex or identify an assay construct. Reviewed UniProtKB entry version 3, sequence version 1; annotation evidence, not an independently inspected primary experiment. snippet Involved in the biosynthesis of the sulfonamide antibiotics altemicidin reference https://www.ncbi.nlm.nih.gov/protein/BBG06564.1 evidence type CURATOR_INFERENCE retrieved on 2026-10-11 notes Native reference: sbzO, 268 aa, Streptomyces sp. NCIMB 40513 (NCBITaxon:1931), reverse-strand LC420052.1:15858..16664. CDS-aware genomic translation, deposited translation, GenPept and UniProt sequences agree exactly without ambiguous residues. This does not establish the sequence of a tagged, fused, truncated or mutated experimental construct.
Altemicidin biosynthesis (annotated participation)	is_annotated_pathway_for	Altemicidin	https://www.uniprot.org/uniprotkb/P0DY37/entry https://www.uniprot.org/uniprotkb/P0DY50/entry https://www.uniprot.org/uniprotkb/P0DY51/entry reference https://www.uniprot.org/uniprotkb/P0DY37/entry evidence type DATABASE_ASSERTION retrieved on 2026-10-11 notes The annotated pathway concerns altemicidin as well as downstream congeners. Participation is not a claim that any one of SbzH/N/O directly produces the final compound. Reviewed UniProtKB entry version 3, sequence version 1; annotation evidence, not an independently inspected primary experiment. reference https://www.uniprot.org/uniprotkb/P0DY50/entry evidence type DATABASE_ASSERTION retrieved on 2026-10-11 notes The annotated pathway concerns altemicidin as well as downstream congeners. Participation is not a claim that any one of SbzH/N/O directly produces the final compound. Reviewed UniProtKB entry version 3, sequence version 1; annotation evidence, not an independently inspected primary experiment. reference https://www.uniprot.org/uniprotkb/P0DY51/entry evidence type DATABASE_ASSERTION retrieved on 2026-10-11 notes The annotated pathway concerns altemicidin as well as downstream congeners. Participation is not a claim that any one of SbzH/N/O directly produces the final compound. Reviewed UniProtKB entry version 3, sequence version 1; annotation evidence, not an independently inspected primary experiment.

Every edge carries its own citation; an uncited edge is refused by the corpus tests.

Explore across X-Mech

AntibioticMech (altemicidin) ↗ MediaIngredientMech (naturalproductmech:mibig-a58ee03ee4) ↗ TaxonMech: Streptomyces sp. (NCBITaxon:1931) ↗ PathwayMech (mibig:BGC0001925) ↗

Open questions 1

curator-altemicidin-sbz-evidence-boundaries — Which primary experimental constructs and intervening steps can be independently verified for the altemicidin Sbz pathway?

Provenance

Source concept	Source	Version
BGC0001925	MIBIG	4

This page is generated from data/natural_products/alkaloids/altemicidin.yaml, which is generated from the committed inventories. Neither is edited by hand.