(−)-anisomycin
CHEBI:338412 EXACT SEEDED antiviral
An antibiotic isolated from various Streptomyces species. It interferes with protein and DNA synthesis by inhibiting peptidyl transferase or the 80S ribosome system.
Structure
| Standard InChIKey | YKJYKKNCCRKFSL-RDBSUJKOSA-N |
|---|---|
| SMILES | COC1=CC=C(C[C@H]2NC[C@H](O)[C@H]2OC(C)=O)C=C1 |
| Stereochemistry | fully defined |
| Cross-references | npatlas:NPA017379 |
Filing pathway
Alkaloids — computed by NPClassifier npclassifier.gnps2.org@2026-09-07, which is why it is pinned rather than recomputed. The gene cluster's asserted class is other, from MIBiG.
Producer organisms 1
A claim that this taxon makes the compound. The basis says what the evidence addressed — a knockout and a database assertion are not the same claim.
| Taxon | Basis | Cluster | Evidence |
|---|---|---|---|
| Streptomyces hygrospinosus NCBITaxon:516360 |
SOURCE_ASSERTION | mibig:BGC0001510 | PMID:28373542 |
Occurrences 3
Somebody found the compound in this organism and cited it. That is not a claim that the organism makes it, and nothing here promotes one to the other.
| Taxon | Source | Reference |
|---|---|---|
| Streptomyces NCBITaxon:1883 |
LOTUS | DOI:10.1021/JA01644A076 |
| Streptomyces NCBITaxon:1883 |
LOTUS | DOI:10.7164/ANTIBIOTICS.46.1300 |
| Streptomyces hygrospinosus NCBITaxon:2719566 |
LOTUS | DOI:10.1016/J.SYNBIO.2018.12.004 |
Biosynthetic gene clusters 1
| Accession | Host | Locus evidence | Genome |
|---|---|---|---|
| mibig:BGC0001510 | Streptomyces hygrospinosus NCBITaxon:516360 |
CLUSTER_UNSTATED | genbank:KY014292.1 |
A locus claim and a taxon claim are different questions. Heterologous expression settles the first and leaves the second where the isolation report left it.
Elsewhere in the fleet
- AntibioticMech — CHEBI:338412 (same structure, same inchikey)
Provenance
| Source concept | Source | Version |
|---|---|---|
| BGC0001510 | MIBIG | 5 |
| CHEBI:338412 | CHEBI | 3-star |
This page is generated from data/natural_products/alkaloids/anisomycin.yaml, which is generated from the committed inventories. Neither is edited by hand.