NaturalProductMech

anthramycin

naturalproductmech:mibig-8b9bc078cd MINTED SEEDED

Structure

Standard InChIKeyVGQOVCHZGQWAOI-HWKANZROSA-N
SMILESCC1=C(O)C2=C(C=C1)C(=O)N1C=C(CC1C(O)N2)\C=C\C(N)=O
Stereochemistry undefined stereocentres — the InChIKey does not distinguish this compound from its stereoisomers
Cross-referencesnpatlas:NPA08987, pubchem:5311005

Filing pathway

Alkaloids — computed by NPClassifier npclassifier.gnps2.org@2026-09-07, which is why it is pinned rather than recomputed. The gene cluster's asserted class is nrps, from MIBiG.

Producer organisms 1

A claim that this taxon makes the compound. The basis says what the evidence addressed — a knockout and a database assertion are not the same claim.

TaxonBasisClusterEvidence
Streptomyces refuineus subsp. thermotolerans
NCBITaxon:223297
SOURCE_ASSERTION mibig:BGC0000303 PMID:17584616

Occurrences 8

Somebody found the compound in this organism and cited it. That is not a claim that the organism makes it, and nothing here promotes one to the other.

TaxonSourceReference
Streptomyces albidoflavus
NCBITaxon:1886
LOTUS DOI:10.1016/J.CHEMBIOL.2007.05.009
Streptomyces albidoflavus
NCBITaxon:1886
LOTUS DOI:10.7164/ANTIBIOTICS.34.1171
Streptomyces coelicolor
NCBITaxon:1902
LOTUS DOI:10.1016/J.CHEMBIOL.2007.05.009
Streptomyces coelicolor
NCBITaxon:1902
LOTUS DOI:10.7164/ANTIBIOTICS.34.1171
Streptomyces refuineus
NCBITaxon:223296
LOTUS DOI:10.1016/J.CHEMBIOL.2007.05.009
Streptomyces refuineus
NCBITaxon:223296
LOTUS DOI:10.1021/NP50013A007
Streptomyces refuineus
NCBITaxon:223296
LOTUS DOI:10.7164/ANTIBIOTICS.33.579
Streptomyces refuineus
NCBITaxon:223296
LOTUS DOI:10.7164/ANTIBIOTICS.34.1171

Biosynthetic gene clusters 1

AccessionHostLocus evidenceGenome
mibig:BGC0000303 Streptomyces refuineus subsp. thermotolerans
NCBITaxon:223297
CLUSTER_UNSTATED genbank:EU195114.1

A locus claim and a taxon claim are different questions. Heterologous expression settles the first and leaves the second where the isolation report left it.

Provenance

Source conceptSourceVersion
BGC0000303MIBIG5

This page is generated from data/natural_products/alkaloids/anthramycin.yaml, which is generated from the committed inventories. Neither is edited by hand.