caerulomycin A
CHEBI:69231 EXACT SEEDED
What these status tags mean
Curation status describes a workflow state. SEEDED means the record entered through the source-seeding workflow; it does not imply that no later curation occurred. PROPOSED marks an addition awaiting review; REVIEWED records curator sign-off on identity, structure, filing class and producer claims; DEPRECATED retains a superseded or out-of-scope record. These are workflow decisions, not independently verified human review. Agent-assisted contributions may appear in the record history.
Grounding describes the identifier mapping: EXACT uses an ontology identity asserted by the source; MINTED keeps a local identifier when no defensible ontology identity is available; REVIEW_NEEDED flags an exact structure whose ontology identity needs adjudication. The grounding note retains any unresolved alternatives. These tags do not establish the strength of producer or activity evidence.
A pyridine alkaloid that is 2,2'-bipyridine substituted by a methoxy group at position 4 and a (E)-(hydroxyimino)methyl group at position 6. Isolated from the marine-derived actinomycete Actinoalloteichus cyanogriseus, it exhibits antineoplastic activity.
Structure
| Standard InChIKey | JCTRJRHLGOKMCF-RIYZIHGNSA-N |
|---|---|
| SMILES | COC1=CC(\C=N\O)=NC(=C1)C1=NC=CC=C1 |
| Stereochemistry | fully defined |
| Cross-references | npatlas:NPA015275, pubchem:5381230 |
Filing pathway
Alkaloids — computed by NPClassifier npclassifier.gnps2.org@2026-09-07, which is why it is pinned rather than recomputed. The gene cluster's asserted class is nrps, pks, from MIBiG.
Producer organisms 1
A claim that this taxon makes the compound. The basis says what the evidence addressed — a knockout and a database assertion are not the same claim.
| Taxon | Basis | Cluster | Evidence |
|---|---|---|---|
| Actinoalloteichus sp. WH1-2216-6 NCBITaxon:1074250 |
SOURCE_ASSERTION | mibig:BGC0000966 | PMID:22591508 |
Occurrences 5
Somebody found the compound in this organism and cited it. That is not a claim that the organism makes it, and nothing here promotes one to the other.
| Taxon | Source | Reference |
|---|---|---|
| Actinoalloteichus cyanogriseus NCBITaxon:2893586 |
LOTUS | DOI:10.1021/NP200258H |
| Actinoalloteichus cyanogriseus NCBITaxon:2893586 |
LOTUS | DOI:10.1139/M59-039 |
| Actinoalloteichus cyanogriseus NCBITaxon:2893586 |
LOTUS | DOI:10.1139/V67-201 |
| Actinoalloteichus cyanogriseus NCBITaxon:2893586 |
LOTUS | DOI:10.1139/V88-031 |
| Actinoalloteichus cyanogriseus NCBITaxon:2893586 |
CHEBI | PMID:21770434 |
Biosynthetic gene clusters 1
| Accession | Host | Locus evidence | Genome |
|---|---|---|---|
| mibig:BGC0000966 | Actinoalloteichus sp. WH1-2216-6 NCBITaxon:1074250 |
CLUSTER_UNSTATED | genbank:JF419316.2 |
A locus claim and a taxon claim are different questions. Heterologous expression settles the first and leaves the second where the isolation report left it.
Mechanism & Biosynthesis Overview
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Provenance
| Source concept | Source | Version |
|---|---|---|
| BGC0000966 | MIBIG | 5 |
| CHEBI:69231 | CHEBI | 3-star |
This page is generated from data/natural_products/alkaloids/caerulomycin-a.yaml, which is generated from the committed inventories. Neither is edited by hand.