closoxazole B
naturalproductmech:mibig-066fb5437f MINTED SEEDED
What these status tags mean
Curation status describes a workflow state. SEEDED means the record entered through the source-seeding workflow; it does not imply that no later curation occurred. PROPOSED marks an addition awaiting review; REVIEWED records curator sign-off on identity, structure, filing class and producer claims; DEPRECATED retains a superseded or out-of-scope record. These are workflow decisions, not independently verified human review. Agent-assisted contributions may appear in the record history.
Grounding describes the identifier mapping: EXACT uses an ontology identity asserted by the source; MINTED keeps a local identifier when no defensible ontology identity is available; REVIEW_NEEDED flags an exact structure whose ontology identity needs adjudication. The grounding note retains any unresolved alternatives. These tags do not establish the strength of producer or activity evidence.
Structure
| Standard InChIKey | HGLRJWFVXKHIAO-UHFFFAOYSA-N |
|---|---|
| SMILES | Nc1ccc(cc1)-c1nc2cc(ccc2o1)C(=O)Nc1cc(ccc1O)C(O)=O |
| Stereochemistry | fully defined |
Filing pathway
Alkaloids — computed by NPClassifier npclassifier.gnps2.org@2026-09-07, which is why it is pinned rather than recomputed. The gene cluster's asserted class is other, from MIBiG.
Producer organisms 1
A claim that this taxon makes the compound. The basis says what the evidence addressed — a knockout and a database assertion are not the same claim.
| Taxon | Basis | Cluster | Evidence |
|---|---|---|---|
| Clostridium cavendishii DSM 21758 NCBITaxon:1121302 |
BGC_CHARACTERIZED | mibig:BGC0002826 | DOI:10.1002/anie.202205409 |
Occurrences 0
None cited.
Biosynthetic gene clusters 1
| Accession | Host | Locus evidence | Genome |
|---|---|---|---|
| mibig:BGC0002826 | Clostridium cavendishii DSM 21758 NCBITaxon:1121302 |
CLUSTER_DEMONSTRATED | genbank:FQZB01000008.1 |
A locus claim and a taxon claim are different questions. Heterologous expression settles the first and leaves the second where the isolation report left it.
Mechanism & Biosynthesis Overview
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Provenance
| Source concept | Source | Version |
|---|---|---|
| BGC0002826 | MIBIG | 2 |
This page is generated from data/natural_products/alkaloids/closoxazole-b.yaml, which is generated from the committed inventories. Neither is edited by hand.