NaturalProductMech

cytochalasin K

naturalproductmech:mibig-5458ad4d20 MINTED SEEDED

Structure

Standard InChIKeyAZWOSJCABFILKS-JTQCMLDWSA-N
SMILES[H][C@]12[C@H](CC3=CC=CC=C3)NC(=O)[C@]11C(=O)\C=C\C(=O)[C@H](OC(C)=O)\C(C)=C\[C@@H](C)C\C=C\[C@@]1([H])[C@@H]1O[C@]1(C)[C@H]2C
Stereochemistryfully defined
Cross-referencespubchem:44583793, npatlas:NPA017129

Filing pathway

Alkaloids — computed by NPClassifier npclassifier.gnps2.org@2026-09-07, which is why it is pinned rather than recomputed. The gene cluster's asserted class is nrps, pks, from MIBiG.

Producer organisms 1

A claim that this taxon makes the compound. The basis says what the evidence addressed — a knockout and a database assertion are not the same claim.

TaxonBasisClusterEvidence
Aspergillus clavatus NRRL 1
NCBITaxon:344612
BGC_CHARACTERIZED mibig:BGC0000983 DOI:10.1016/s0040-4039(01)92975-2

Occurrences 1

Somebody found the compound in this organism and cited it. That is not a claim that the organism makes it, and nothing here promotes one to the other.

TaxonSourceReference
Chalara microspora
NCBITaxon:112125
LOTUS DOI:10.1016/S0040-4039(01)92975-2

Biosynthetic gene clusters 1

AccessionHostLocus evidenceGenome
mibig:BGC0000983 Aspergillus clavatus NRRL 1
NCBITaxon:344612
CLUSTER_DEMONSTRATED genbank:DS027057.1

A locus claim and a taxon claim are different questions. Heterologous expression settles the first and leaves the second where the isolation report left it.

Provenance

Source conceptSourceVersion
BGC0000983MIBIG5

This page is generated from data/natural_products/alkaloids/cytochalasin-k.yaml, which is generated from the committed inventories. Neither is edited by hand.