diazaquinomycin A
naturalproductmech:mibig-e4996ae028 MINTED SEEDED cytotoxic
Structure
| Standard InChIKey | WZZGVUSWZMBPPL-UHFFFAOYSA-N |
|---|---|
| SMILES | CCCC1=C(C(=O)NC2=C1C(=O)C3=C(C2=O)NC(=O)C(=C3CCC)C)C |
| Stereochemistry | fully defined |
| Cross-references | pubchem:122105 |
Filing pathway
Alkaloids — computed by NPClassifier npclassifier.gnps2.org@2026-09-07, which is why it is pinned rather than recomputed. The gene cluster's asserted class is other, from MIBiG.
Producer organisms 1
A claim that this taxon makes the compound. The basis says what the evidence addressed — a knockout and a database assertion are not the same claim.
| Taxon | Basis | Cluster | Evidence |
|---|---|---|---|
| Streptomyces sp. F001 NCBITaxon:1510026 |
SOURCE_ASSERTION | mibig:BGC0001850 | DOI:10.3390/md12063574 |
Occurrences 4
Somebody found the compound in this organism and cited it. That is not a claim that the organism makes it, and nothing here promotes one to the other.
| Taxon | Source | Reference |
|---|---|---|
| Streptomyces NCBITaxon:1883 |
LOTUS | DOI:10.1016/S0040-4039(00)88190-3 |
| Streptomyces NCBITaxon:1883 |
LOTUS | DOI:10.3390/MD12063574 |
| Streptomyces NCBITaxon:1883 |
LOTUS | DOI:10.7164/ANTIBIOTICS.35.1425 |
| Streptomyces NCBITaxon:1883 |
LOTUS | DOI:10.7164/ANTIBIOTICS.38.1025 |
Biosynthetic gene clusters 1
| Accession | Host | Locus evidence | Genome |
|---|---|---|---|
| mibig:BGC0001850 | Streptomyces sp. F001 NCBITaxon:1510026 |
CLUSTER_UNSTATED | genbank:QZWF01000007.1 |
A locus claim and a taxon claim are different questions. Heterologous expression settles the first and leaves the second where the isolation report left it.
Bioactivities 12
| Assay | Result | Reference |
|---|---|---|
| A2780 Cisplatin Sensitive Ovarian Cancer Cell Toxicity qHTS against the NCATS CANVASS Library | ACTIVE | PMID:30648156 |
| COV-362 Cancer Cell Toxicity qHTS against the NCATS CANVASS Library | ACTIVE | PMID:30648156 |
| OV-SAHO Cancer Cell Toxicity qHTS against the NCATS CANVASS Library | ACTIVE | PMID:30648156 |
| Panc-1005 Cancer Cell Toxicity qHTS against the NCATS CANVASS Library | ACTIVE | PMID:30648156 |
| Primary screen NINDS Rhodamine qHTS for Zika virus inhibitors | ACTIVE | PMID:33229545 |
| Redox Reaction Profiling qHTS: Assay Interference Panel against the NCATS CANVASS Library | ACTIVE | PMID:30648156 |
| SW1088 Cancer Cell Toxicity qHTS against the NCATS CANVASS Library | ACTIVE | PMID:30648156 |
| UWB1.289 Cancer Cell Toxicity qHTS against the NCATS CANVASS Library | ACTIVE | PMID:30648156 |
| UWB1.289-WTBRCA1 Cancer Cell Toxicity qHTS against the NCATS CANVASS Library | ACTIVE | PMID:30648156 |
| qHTS for Antimalaria activity screened against the NCATS CANVASS Library | ACTIVE | PMID:30648156 |
| qHTS for Hypoxia signaling pathway (HIF-1) antagonists against the NCATS CANVASS Library | ACTIVE | PMID:30648156 |
| qHTS for Hypoxia signaling pathway (HIF-1) antagonists against the NCATS CANVASS Library | ACTIVE | PMID:30648156 |
Provenance
| Source concept | Source | Version |
|---|---|---|
| BGC0001850 | MIBIG | 4 |
This page is generated from data/natural_products/alkaloids/diazaquinomycin-a.yaml, which is generated from the committed inventories. Neither is edited by hand.