diazaquinomycin A

naturalproductmech:mibig-e4996ae028 MINTED SEEDED cytotoxic

Grounding review: No 3-star ChEBI entry shares this structure, so the record keeps a content-hashed identifier.

What these status tags mean

Curation status describes a workflow state. SEEDED means the record entered through the source-seeding workflow; it does not imply that no later curation occurred. PROPOSED marks an addition awaiting review; REVIEWED records curator sign-off on identity, structure, filing class and producer claims; DEPRECATED retains a superseded or out-of-scope record. These are workflow decisions, not independently verified human review. Agent-assisted contributions may appear in the record history.

Grounding describes the identifier mapping: EXACT uses an ontology identity asserted by the source; MINTED keeps a local identifier when no defensible ontology identity is available; REVIEW_NEEDED flags an exact structure whose ontology identity needs adjudication. The grounding note retains any unresolved alternatives. These tags do not establish the strength of producer or activity evidence.

Structure

Standard InChIKey	WZZGVUSWZMBPPL-UHFFFAOYSA-N
SMILES	CCCC1=C(C(=O)NC2=C1C(=O)C3=C(C2=O)NC(=O)C(=C3CCC)C)C
Stereochemistry	fully defined
Cross-references	pubchem:122105

Filing pathway

Alkaloids — computed by NPClassifier npclassifier.gnps2.org@2026-09-07, which is why it is pinned rather than recomputed. The gene cluster's asserted class is other, from MIBiG.

Producer organisms 1

A claim that this taxon makes the compound. The basis says what the evidence addressed — a knockout and a database assertion are not the same claim.

Taxon	Basis	Cluster	Evidence
Streptomyces sp. F001 NCBITaxon:1510026	SOURCE_ASSERTION	mibig:BGC0001850	DOI:10.3390/md12063574

Occurrences 4

Somebody found the compound in this organism and cited it. That is not a claim that the organism makes it, and nothing here promotes one to the other.

Taxon	Source	Reference
Streptomyces NCBITaxon:1883	LOTUS	DOI:10.1016/S0040-4039(00)88190-3
Streptomyces NCBITaxon:1883	LOTUS	DOI:10.3390/MD12063574
Streptomyces NCBITaxon:1883	LOTUS	DOI:10.7164/ANTIBIOTICS.35.1425
Streptomyces NCBITaxon:1883	LOTUS	DOI:10.7164/ANTIBIOTICS.38.1025

Biosynthetic gene clusters 1

Accession	Host	Locus evidence	Genome
mibig:BGC0001850	Streptomyces sp. F001 NCBITaxon:1510026	CLUSTER_UNSTATED	genbank:QZWF01000007.1

A locus claim and a taxon claim are different questions. Heterologous expression settles the first and leaves the second where the isolation report left it.

Mechanism & Biosynthesis Overview

Bioactivities 12

Entries preserve source qualifiers, targets and evidence. Repeated assay names or values are not independent replications; inspect source detail for differences.

Assay	Result	Target enzyme	Source detail
A2780 Cisplatin Sensitive Ovarian Cancer Cell Toxicity qHTS against the NCATS CANVASS Library	ACTIVE	Not recorded	PMID:30648156 assay A2780 Cisplatin Sensitive Ovarian Cancer Cell Toxicity qHTS against the NCATS CANVASS Library evidence reference PMID:30648156 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 1347353, deposited by NCGC; assay type Confirmatory. call ACTIVE activity class CYTOTOXIC
COV-362 Cancer Cell Toxicity qHTS against the NCATS CANVASS Library	ACTIVE	Not recorded	PMID:30648156 assay COV-362 Cancer Cell Toxicity qHTS against the NCATS CANVASS Library evidence reference PMID:30648156 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 1347352, deposited by NCGC; assay type Confirmatory. call ACTIVE activity class CYTOTOXIC
OV-SAHO Cancer Cell Toxicity qHTS against the NCATS CANVASS Library	ACTIVE	Not recorded	PMID:30648156 assay OV-SAHO Cancer Cell Toxicity qHTS against the NCATS CANVASS Library evidence reference PMID:30648156 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 1347348, deposited by NCGC; assay type Confirmatory. call ACTIVE activity class CYTOTOXIC
Panc-1005 Cancer Cell Toxicity qHTS against the NCATS CANVASS Library	ACTIVE	Not recorded	PMID:30648156 assay Panc-1005 Cancer Cell Toxicity qHTS against the NCATS CANVASS Library evidence reference PMID:30648156 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 1347349, deposited by NCGC; assay type Confirmatory. call ACTIVE activity class CYTOTOXIC
Primary screen NINDS Rhodamine qHTS for Zika virus inhibitors	ACTIVE	Not recorded	PMID:33229545 assay Primary screen NINDS Rhodamine qHTS for Zika virus inhibitors evidence reference PMID:33229545 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 1347160, deposited by NCGC; assay type Confirmatory. call ACTIVE
Redox Reaction Profiling qHTS: Assay Interference Panel against the NCATS CANVASS Library	ACTIVE	Not recorded	PMID:30648156 assay Redox Reaction Profiling qHTS: Assay Interference Panel against the NCATS CANVASS Library evidence reference PMID:30648156 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 1347401, deposited by NCGC; assay type Confirmatory. call ACTIVE
SW1088 Cancer Cell Toxicity qHTS against the NCATS CANVASS Library	ACTIVE	Not recorded	PMID:30648156 assay SW1088 Cancer Cell Toxicity qHTS against the NCATS CANVASS Library evidence reference PMID:30648156 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 1347350, deposited by NCGC; assay type Confirmatory. call ACTIVE activity class CYTOTOXIC
UWB1.289 Cancer Cell Toxicity qHTS against the NCATS CANVASS Library	ACTIVE	Not recorded	PMID:30648156 assay UWB1.289 Cancer Cell Toxicity qHTS against the NCATS CANVASS Library evidence reference PMID:30648156 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 1347347, deposited by NCGC; assay type Confirmatory. call ACTIVE activity class CYTOTOXIC
UWB1.289-WTBRCA1 Cancer Cell Toxicity qHTS against the NCATS CANVASS Library	ACTIVE	Not recorded	PMID:30648156 assay UWB1.289-WTBRCA1 Cancer Cell Toxicity qHTS against the NCATS CANVASS Library evidence reference PMID:30648156 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 1347354, deposited by NCGC; assay type Confirmatory. call ACTIVE activity class CYTOTOXIC
qHTS for Antimalaria activity screened against the NCATS CANVASS Library	ACTIVE	Not recorded	PMID:30648156 assay qHTS for Antimalaria activity screened against the NCATS CANVASS Library evidence reference PMID:30648156 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 1347380, deposited by NCGC; assay type Confirmatory. call ACTIVE
qHTS for Hypoxia signaling pathway (HIF-1) antagonists against the NCATS CANVASS Library	ACTIVE	Not recorded	PMID:30648156 assay qHTS for Hypoxia signaling pathway (HIF-1) antagonists against the NCATS CANVASS Library evidence reference PMID:30648156 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 1347374, deposited by NCGC; assay type Confirmatory. call ACTIVE
qHTS for Hypoxia signaling pathway (HIF-1) antagonists against the NCATS CANVASS Library	ACTIVE	Not recorded	PMID:30648156 assay qHTS for Hypoxia signaling pathway (HIF-1) antagonists against the NCATS CANVASS Library evidence reference PMID:30648156 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 1347374, deposited by NCGC; assay type Confirmatory. Target accession AAC68568 was left ungrounded because PubChem did not provide a UniProtKB accession. call ACTIVE

Explore across X-Mech

AntibioticMech (diazaquinomycin A) ↗ MediaIngredientMech (naturalproductmech:mibig-e4996ae028) ↗ TaxonMech: Streptomyces sp. F001 (NCBITaxon:1510026) ↗ PathwayMech (mibig:BGC0001850) ↗

Provenance

Source concept	Source	Version
BGC0001850	MIBIG	4

This page is generated from data/natural_products/alkaloids/diazaquinomycin-a.yaml, which is generated from the committed inventories. Neither is edited by hand.