distamycin
naturalproductmech:mibig-5fbc59612b MINTED SEEDED antiparasiticenzyme inhibitor
Structure
| Standard InChIKey | UPBAOYRENQEPJO-UHFFFAOYSA-N |
|---|---|
| SMILES | CN1C=C(C=C1C(=O)NC2=CN(C(=C2)C(=O)NC3=CN(C(=C3)C(=O)NCCC(=N)N)C)C)NC=O |
| Stereochemistry | fully defined |
| Cross-references | pubchem:3115 |
Filing pathway
Alkaloids — computed by NPClassifier npclassifier.gnps2.org@2026-09-07, which is why it is pinned rather than recomputed. The gene cluster's asserted class is nrps, from MIBiG.
Producer organisms 1
A claim that this taxon makes the compound. The basis says what the evidence addressed — a knockout and a database assertion are not the same claim.
| Taxon | Basis | Cluster | Evidence |
|---|---|---|---|
| Streptomyces netropsis NCBITaxon:55404 |
BGC_CHARACTERIZED | mibig:BGC0001147 | PMID:25415678 |
Occurrences 0
None cited.
Biosynthetic gene clusters 1
| Accession | Host | Locus evidence | Genome |
|---|---|---|---|
| mibig:BGC0001147 | Streptomyces netropsis NCBITaxon:55404 |
CLUSTER_DEMONSTRATED | genbank:KJ634466.1 |
A locus claim and a taxon claim are different questions. Heterologous expression settles the first and leaves the second where the isolation report left it.
Bioactivities 7
| Assay | Result | Reference |
|---|---|---|
| Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation | 3.3808 uM | pubchem.aid:504832 |
| S16 Schwann cell PMP22 intronic element firefly luciferase assay | 36.1254 uM | pubchem.aid:624032 |
| qHTS assay for small molecule disruptors of the mitochondrial membrane potential | 33.4915 uM | pubchem.aid:720635 |
| qHTS for Inhibitors of Polymerase Kappa | 0.7943 uM | pubchem.aid:588579 |
| qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT | 0.0188 uM | pubchem.aid:686979 |
| qHTS profiling for inhibitors of Plasmodium falciparum proliferation | ACTIVE | PMID:21817045 |
| qHTS profiling for inhibitors of Plasmodium falciparum proliferation | ACTIVE | PMID:21817045 |
Provenance
| Source concept | Source | Version |
|---|---|---|
| BGC0001147 | MIBIG | 4 |
This page is generated from data/natural_products/alkaloids/distamycin.yaml, which is generated from the committed inventories. Neither is edited by hand.