erdasporine A
CHEBI:156313 EXACT SEEDED antibacterial
A organic heterohexacyclic compound that is 12,13-dihydro-6H-indolo[2,3-a]pyrrolo[3,4-c]carbazole in which the hydrogens at positions 5 and 10 are substituted by a methoxycarbonyl and hydroxy groups, respectively. It is synthesized by a gene cluster found in environmental DNA and exhibits cytotoxic activity against human HCT116 cancer cells and Staphylococcus aureus.
Structure
| Standard InChIKey | WIKWOGJGVQUVBW-UHFFFAOYSA-N |
|---|---|
| SMILES | COC(=O)C1=C2C(=CN1)C3=C(C4=C2C5=CC=CC=C5N4)NC6=C3C=CC(=C6)O |
| Stereochemistry | fully defined |
| Cross-references | pubchem:102584105 |
Filing pathway
Alkaloids — computed by NPClassifier npclassifier.gnps2.org@2026-09-07, which is why it is pinned rather than recomputed. The gene cluster's asserted class is other, from MIBiG.
Producer organisms 0
None. The compound has a characterized gene cluster whose host NCBI does not name, which for an uncultured symbiont is the honest state — see the discussion below.
Occurrences 0
None cited.
Biosynthetic gene clusters 1
| Accession | Host | Locus evidence | Genome |
|---|---|---|---|
| mibig:BGC0001336 | not named | CLUSTER_DEMONSTRATED | genbank:KF551865.1 |
A locus claim and a taxon claim are different questions. Heterologous expression settles the first and leaves the second where the isolation report left it.
Elsewhere in the fleet
- AntibioticMech — CHEBI:156313 (same structure, same inchikey)
Open questions 1
unnamed-producer — No producer claim is written from BGC0001336, which gives NCBITaxon:77133 (uncultured bacterium — shared by every unplaced bacterium), because the taxon names no single organism. The cluster is kept: a characterized locus is an origin assertion whether or not its host has a name, and for a compound from an uncultured symbiont that is the honest state. Name the producer if the primary literature does.
Provenance
| Source concept | Source | Version |
|---|---|---|
| BGC0001336 | MIBIG | 5 |
| CHEBI:156313 | CHEBI | 3-star |
This page is generated from data/natural_products/alkaloids/erdasporine-a.yaml, which is generated from the committed inventories. Neither is edited by hand.