fervenulin
naturalproductmech:mibig-f2f849b16f MINTED SEEDED antibacterialcytotoxicenzyme inhibitor
Structure
| Standard InChIKey | RRTKVYSLIGQWCO-UHFFFAOYSA-N |
|---|---|
| SMILES | CN1C2=C(C(=O)N(C1=O)C)N=CN=N2 |
| Stereochemistry | fully defined |
| Cross-references | pubchem:249646 |
Filing pathway
Alkaloids — computed by NPClassifier npclassifier.gnps2.org@2026-09-07, which is why it is pinned rather than recomputed. The gene cluster's asserted class is other, from MIBiG.
Producer organisms 1
A claim that this taxon makes the compound. The basis says what the evidence addressed — a knockout and a database assertion are not the same claim.
| Taxon | Basis | Cluster | Evidence |
|---|---|---|---|
| Streptomyces hiroshimensis NCBITaxon:66424 |
SOURCE_ASSERTION | mibig:BGC0001972 | PMID:30565634 |
Occurrences 3
Somebody found the compound in this organism and cited it. That is not a claim that the organism makes it, and nothing here promotes one to the other.
| Taxon | Source | Reference |
|---|---|---|
| Streptomyces hiroshimensis NCBITaxon:66424 |
LOTUS | DOI:10.1007/S11274-010-0588-Z |
| Streptomyces hiroshimensis NCBITaxon:66424 |
LOTUS | DOI:10.1007/S11306-016-1025-6 |
| Streptomyces hiroshimensis NCBITaxon:66424 |
LOTUS | DOI:10.1039/C8OB02847H |
Biosynthetic gene clusters 1
| Accession | Host | Locus evidence | Genome |
|---|---|---|---|
| mibig:BGC0001972 | Streptomyces hiroshimensis NCBITaxon:66424 |
CLUSTER_UNSTATED | genbank:MK256951.1 |
A locus claim and a taxon claim are different questions. Heterologous expression settles the first and leaves the second where the isolation report left it.
Bioactivities 17
| Assay | Result | Reference |
|---|---|---|
| A screen for compounds that inhibit replication of Vibrio cholerae chromosome II | ACTIVE | pubchem.aid:504770 |
| A screen for compounds that inhibit the activity of LtaS in Staphylococcus aureus | ACTIVE | pubchem.aid:720641 |
| A screen for compounds that inhibit viral RNA polymerase binding and polymerization activities | ACTIVE | PMID:21722674 |
| High-throughput screen for inhibitors of the GIV GBA-motif interaction with Galpha-i G protein subunits | ACTIVE | pubchem.aid:1224905 |
| High-throughput screen for inhibitors of the GIV GBA-motif interaction with Galpha-i G protein subunits | ACTIVE | pubchem.aid:1224905 |
| High-throughput screen for inhibitors of the GIV GBA-motif interaction with Galpha-i G protein subunits, FP Hit Confirmation | ACTIVE | pubchem.aid:1259350 |
| NCI In Vivo Anticancer Drug Screen. Data for tumor model P388 Leukemia (intraperitoneal) in B6D2F1 (BDF1) mice | ACTIVE | pubchem.aid:328 |
| OTUD3 deubiquitinase inhibition: Primary qHTS | ACTIVE | pubchem.aid:1645858 |
| UCHL1 deubiquitinase inhibition: Dose-response Confirmation | ACTIVE | pubchem.aid:1645867 |
| UCHL1 deubiquitinase inhibition: Primary qHTS | ACTIVE | pubchem.aid:1645859 |
| USP10 deubiquitinase inhibition: Dose-response Confirmation | ACTIVE | pubchem.aid:1645863 |
| USP10 deubiquitinase inhibition: Primary qHTS | ACTIVE | pubchem.aid:1645856 |
| USP17 deubiquitinase inhibition: Primary qHTS | ACTIVE | pubchem.aid:1645855 |
| USP28 deubiquitinase inhibition: Primary qHTS | ACTIVE | pubchem.aid:1645857 |
| USP30 deubiquitinase inhibition: Primary qHTS | ACTIVE | pubchem.aid:1645860 |
| USP8 deubiquitinase inhibition: Dose-response Confirmation | ACTIVE | pubchem.aid:1645862 |
| USP8 deubiquitinase inhibition: Primary qHTS | ACTIVE | pubchem.aid:1645853 |
Provenance
| Source concept | Source | Version |
|---|---|---|
| BGC0001972 | MIBIG | 4 |
This page is generated from data/natural_products/alkaloids/fervenulin.yaml, which is generated from the committed inventories. Neither is edited by hand.