formycin A
CHEBI:42452 EXACT SEEDED antimicrobial unspecifiedenzyme inhibitor
Structure
| Standard InChIKey | KBHMEHLJSZMEMI-KSYZLYKTSA-N |
|---|---|
| SMILES | C1=NC2=C(NN=C2C(=N1)N)[C@H]3[C@@H]([C@@H]([C@H](O3)CO)O)O |
| Stereochemistry | fully defined |
| Cross-references | pubchem:447199 |
Filing pathway
Alkaloids — computed by NPClassifier npclassifier.gnps2.org@2026-09-07, which is why it is pinned rather than recomputed. The gene cluster's asserted class is other, from MIBiG.
Producer organisms 3
A claim that this taxon makes the compound. The basis says what the evidence addressed — a knockout and a database assertion are not the same claim.
| Taxon | Basis | Cluster | Evidence |
|---|---|---|---|
| Streptomyces kaniharaensis NCBITaxon:212423 |
BGC_CHARACTERIZED | mibig:BGC0002282 | DOI:10.1016/j.bmc.2022.116613 |
| Nocardia interforma ATCC 21072 NCBITaxon:1311815 |
SOURCE_ASSERTION | mibig:BGC0002039 | DOI:10.1016/j.bmc.2022.116613 |
| Streptomyces kaniharaensis NCBITaxon:212423 |
SOURCE_ASSERTION | mibig:BGC0002040 | DOI:10.1016/j.bmc.2022.116613 |
Occurrences 1
Somebody found the compound in this organism and cited it. That is not a claim that the organism makes it, and nothing here promotes one to the other.
| Taxon | Source | Reference |
|---|---|---|
| Streptomyces sparsogenes NCBITaxon:67365 |
LOTUS | DOI:10.1016/S0021-9673(01)83861-9 |
Biosynthetic gene clusters 3
| Accession | Host | Locus evidence | Genome |
|---|---|---|---|
| mibig:BGC0002282 | Streptomyces kaniharaensis NCBITaxon:212423 |
CLUSTER_DEMONSTRATED | genbank:WBOF01000001.1 |
| mibig:BGC0002039 | Nocardia interforma ATCC 21072 NCBITaxon:1311815 |
CLUSTER_UNSTATED | genbank:KY682079.1 |
| mibig:BGC0002040 | Streptomyces kaniharaensis NCBITaxon:212423 |
CLUSTER_UNSTATED | genbank:KY705052.1 |
A locus claim and a taxon claim are different questions. Heterologous expression settles the first and leaves the second where the isolation report left it.
Bioactivities 5
| Assay | Result | Reference |
|---|---|---|
| Experimentally measured binding affinity data (Ki) for protein-ligand complexes derived from PDB | KI 10 uM | PMID:12496243 |
| Experimentally measured binding affinity data (Ki) for protein-ligand complexes derived from PDB | KI 10 uM | PMID:12496243 |
| Experimentally measured binding affinity data (Ki) for protein-ligand complexes derived from PDB | KI 48 uM | PMID:18342331 |
| Experimentally measured binding affinity data (Ki) for protein-ligand complexes derived from PDB | KI 48 uM | PMID:18342331 |
| Experimentally measured binding affinity data derived from PDB | ACTIVE | PMID:12496243 |
Elsewhere in the fleet
- AntibioticMech — CHEBI:42452 (same structure, same inchikey)
Open questions 1
shared-structure — This structure is reported by more than one MIBiG entry: BGC0002039, BGC0002040, BGC0002282. Confirm they describe the same compound rather than an upstream cross-reference error.
Provenance
| Source concept | Source | Version |
|---|---|---|
| BGC0002282 | MIBIG | 2 |
| BGC0002039 | MIBIG | 3 |
| BGC0002040 | MIBIG | 3 |
| CHEBI:42452 | CHEBI | 3-star |
This page is generated from data/natural_products/alkaloids/formycin-a.yaml, which is generated from the committed inventories. Neither is edited by hand.