fumiquinazoline A

CHEBI:64546 EXACT SEEDED

What these status tags mean

Curation status describes a workflow state. SEEDED means the record entered through the source-seeding workflow; it does not imply that no later curation occurred. PROPOSED marks an addition awaiting review; REVIEWED records curator sign-off on identity, structure, filing class and producer claims; DEPRECATED retains a superseded or out-of-scope record. These are workflow decisions, not independently verified human review. Agent-assisted contributions may appear in the record history.

Grounding describes the identifier mapping: EXACT uses an ontology identity asserted by the source; MINTED keeps a local identifier when no defensible ontology identity is available; REVIEW_NEEDED flags an exact structure whose ontology identity needs adjudication. The grounding note retains any unresolved alternatives. These tags do not establish the strength of producer or activity evidence.

A fumiquinazoline that consists of imidazoindole and pyrazinoquinazoline units connected by a methylene group.

Structure

Standard InChIKey	DQQCCKFZJNINST-VCPZKGNQSA-N
SMILES	[H][C@]12N[C@@H](C)C(=O)N1C1=CC=CC=C1[C@@]2(O)C[C@@]1([H])N2C(=O)C3=C(C=CC=C3)N=C2[C@H](C)NC1=O
Stereochemistry	fully defined
Cross-references	npatlas:NPA05162, pubchem:11247802

Filing pathway

Alkaloids — computed by NPClassifier npclassifier.gnps2.org@2026-09-07, which is why it is pinned rather than recomputed. The gene cluster's asserted class is nrps, from MIBiG.

Producer organisms 1

A claim that this taxon makes the compound. The basis says what the evidence addressed — a knockout and a database assertion are not the same claim.

Taxon	Basis	Cluster	Evidence
Aspergillus fumigatus Af293 NCBITaxon:330879	BGC_CHARACTERIZED	mibig:BGC0000355	PMID:21899262

Occurrences 4

Somebody found the compound in this organism and cited it. That is not a claim that the organism makes it, and nothing here promotes one to the other.

Taxon	Source	Reference
Aspergillus fumigatus NCBITaxon:746128	LOTUS	DOI:10.1016/S0040-4039(00)91690-3
Aspergillus fumigatus NCBITaxon:746128	LOTUS	DOI:10.1021/BI201302W
Aspergillus fumigatus NCBITaxon:746128	LOTUS	DOI:10.1021/JF300146N
Aspergillus fumigatus NCBITaxon:746128	LOTUS	DOI:10.1039/P19950002345

Biosynthetic gene clusters 1

Accession	Host	Locus evidence	Genome
mibig:BGC0000355	Aspergillus fumigatus Af293 NCBITaxon:330879	CLUSTER_DEMONSTRATED	genbank:CM000174.1

A locus claim and a taxon claim are different questions. Heterologous expression settles the first and leaves the second where the isolation report left it.

Mechanism & Biosynthesis Overview

Bioactivities 3

Entries preserve source qualifiers, targets and evidence. Repeated assay names or values are not independent replications; inspect source detail for differences.

Assay	Result	Target enzyme	Source detail
Primary fluorescence-based thiol-reactive (MSTI) qHTS assay for identification of artifact compounds.	OTHER 10.35 uM; INACTIVE	Not recorded	pubchem.aid:1845221 assay Primary fluorescence-based thiol-reactive (MSTI) qHTS assay for identification of artifact compounds. evidence reference pubchem.aid:1845221 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 1845221, deposited by NCGC; assay type Confirmatory. Source endpoint: Potency. call INACTIVE measurement type OTHER value 10.35 units uM
Viability qHTS for spleen associated tyrosine kinase inhibitor (SYKi) drug resistant MV4-11 cells	OTHER 4.4749 uM; NOT_DETERMINED	Not recorded	pubchem.aid:1963824 assay Viability qHTS for spleen associated tyrosine kinase inhibitor (SYKi) drug resistant MV4-11 cells evidence reference pubchem.aid:1963824 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 1963824, deposited by NCGC; assay type Confirmatory. Source outcome: Inconclusive. Source endpoint: Potency. call NOT_DETERMINED measurement type OTHER value 4.4749 units uM
Viability qHTS for spleen associated tyrosine kinase inhibitor (SYKi) drug resistant MV4-11 cells	OTHER 4.4749 uM; NOT_DETERMINED	UniProtKB:P43405	pubchem.aid:1963824 assay Viability qHTS for spleen associated tyrosine kinase inhibitor (SYKi) drug resistant MV4-11 cells evidence reference pubchem.aid:1963824 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 1963824, deposited by NCGC; assay type Confirmatory. Source outcome: Inconclusive. Source endpoint: Potency. call NOT_DETERMINED measurement type OTHER value 4.4749 units uM target enzyme UniProtKB:P43405

Explore across X-Mech

AntibioticMech (fumiquinazoline A) ↗ MediaIngredientMech (CHEBI:64546) ↗ TaxonMech: Aspergillus fumigatus Af293 (NCBITaxon:330879) ↗ PathwayMech (mibig:BGC0000355) ↗

Provenance

Source concept	Source	Version
BGC0000355	MIBIG	5
CHEBI:64546	CHEBI	3-star

This page is generated from data/natural_products/alkaloids/fumiquinazoline-a.yaml, which is generated from the committed inventories. Neither is edited by hand.