fumiquinazoline A
CHEBI:64546 EXACT SEEDED
A fumiquinazoline that consists of imidazoindole and pyrazinoquinazoline units connected by a methylene group.
Structure
| Standard InChIKey | DQQCCKFZJNINST-VCPZKGNQSA-N |
|---|---|
| SMILES | [H][C@]12N[C@@H](C)C(=O)N1C1=CC=CC=C1[C@@]2(O)C[C@@]1([H])N2C(=O)C3=C(C=CC=C3)N=C2[C@H](C)NC1=O |
| Stereochemistry | fully defined |
| Cross-references | npatlas:NPA05162, pubchem:11247802 |
Filing pathway
Alkaloids — computed by NPClassifier npclassifier.gnps2.org@2026-09-07, which is why it is pinned rather than recomputed. The gene cluster's asserted class is nrps, from MIBiG.
Producer organisms 1
A claim that this taxon makes the compound. The basis says what the evidence addressed — a knockout and a database assertion are not the same claim.
| Taxon | Basis | Cluster | Evidence |
|---|---|---|---|
| Aspergillus fumigatus Af293 NCBITaxon:330879 |
BGC_CHARACTERIZED | mibig:BGC0000355 | PMID:21899262 |
Occurrences 4
Somebody found the compound in this organism and cited it. That is not a claim that the organism makes it, and nothing here promotes one to the other.
| Taxon | Source | Reference |
|---|---|---|
| Aspergillus fumigatus NCBITaxon:746128 |
LOTUS | DOI:10.1016/S0040-4039(00)91690-3 |
| Aspergillus fumigatus NCBITaxon:746128 |
LOTUS | DOI:10.1021/BI201302W |
| Aspergillus fumigatus NCBITaxon:746128 |
LOTUS | DOI:10.1021/JF300146N |
| Aspergillus fumigatus NCBITaxon:746128 |
LOTUS | DOI:10.1039/P19950002345 |
Biosynthetic gene clusters 1
| Accession | Host | Locus evidence | Genome |
|---|---|---|---|
| mibig:BGC0000355 | Aspergillus fumigatus Af293 NCBITaxon:330879 |
CLUSTER_DEMONSTRATED | genbank:CM000174.1 |
A locus claim and a taxon claim are different questions. Heterologous expression settles the first and leaves the second where the isolation report left it.
Bioactivities 3
| Assay | Result | Reference |
|---|---|---|
| Primary fluorescence-based thiol-reactive (MSTI) qHTS assay for identification of artifact compounds. | 10.35 uM | pubchem.aid:1845221 |
| Viability qHTS for spleen associated tyrosine kinase inhibitor (SYKi) drug resistant MV4-11 cells | 4.4749 uM | pubchem.aid:1963824 |
| Viability qHTS for spleen associated tyrosine kinase inhibitor (SYKi) drug resistant MV4-11 cells | 4.4749 uM | pubchem.aid:1963824 |
Provenance
| Source concept | Source | Version |
|---|---|---|
| BGC0000355 | MIBIG | 5 |
| CHEBI:64546 | CHEBI | 3-star |
This page is generated from data/natural_products/alkaloids/fumiquinazoline-a.yaml, which is generated from the committed inventories. Neither is edited by hand.