fumiquinazoline D

naturalproductmech:mibig-e85e28c3e4 MINTED SEEDED

Grounding review: No 3-star ChEBI entry shares this structure, so the record keeps a content-hashed identifier.

What these status tags mean

Curation status describes a workflow state. SEEDED means the record entered through the source-seeding workflow; it does not imply that no later curation occurred. PROPOSED marks an addition awaiting review; REVIEWED records curator sign-off on identity, structure, filing class and producer claims; DEPRECATED retains a superseded or out-of-scope record. These are workflow decisions, not independently verified human review. Agent-assisted contributions may appear in the record history.

Grounding describes the identifier mapping: EXACT uses an ontology identity asserted by the source; MINTED keeps a local identifier when no defensible ontology identity is available; REVIEW_NEEDED flags an exact structure whose ontology identity needs adjudication. The grounding note retains any unresolved alternatives. These tags do not establish the strength of producer or activity evidence.

Structure

Standard InChIKey	YYLAARMDRFESOL-CVAYNVNESA-N
SMILES	C[C@H]1C(=O)N2[C@@H]3N1[C@]4(C5=NC6=CC=CC=C6C(=O)N5[C@H](C[C@@]3(C7=CC=CC=C72)O)C(=O)N4)C
Stereochemistry	fully defined
Cross-references	pubchem:9980845

Filing pathway

Alkaloids — computed by NPClassifier npclassifier.gnps2.org@2026-09-07, which is why it is pinned rather than recomputed. The gene cluster's asserted class is nrps, from MIBiG.

Producer organisms 1

A claim that this taxon makes the compound. The basis says what the evidence addressed — a knockout and a database assertion are not the same claim.

Taxon	Basis	Cluster	Evidence
Aspergillus fumigatus Af293 NCBITaxon:330879	BGC_CHARACTERIZED	mibig:BGC0000355	PMID:21899262

Occurrences 2

Somebody found the compound in this organism and cited it. That is not a claim that the organism makes it, and nothing here promotes one to the other.

Taxon	Source	Reference
Aspergillus fumigatus NCBITaxon:746128	LOTUS	DOI:10.1021/JF300146N
Aspergillus fumigatus NCBITaxon:746128	LOTUS	DOI:10.1039/P19950002345

Biosynthetic gene clusters 1

Accession	Host	Locus evidence	Genome
mibig:BGC0000355	Aspergillus fumigatus Af293 NCBITaxon:330879	CLUSTER_DEMONSTRATED	genbank:CM000174.1

A locus claim and a taxon claim are different questions. Heterologous expression settles the first and leaves the second where the isolation report left it.

Mechanism & Biosynthesis Overview

Bioactivities 5

Entries preserve source qualifiers, targets and evidence. Repeated assay names or values are not independent replications; inspect source detail for differences.

Assay	Result	Target enzyme	Source detail
Primary qHTS for inhibitors of nuclear receptor binding SET domain protein 2 (NSD2) in an RCH-ACV wild type WT cells (2C)	OTHER 8.9285 uM; NOT_DETERMINED	Not recorded	pubchem.aid:1645877 assay Primary qHTS for inhibitors of nuclear receptor binding SET domain protein 2 (NSD2) in an RCH-ACV wild type WT cells (2C) evidence reference pubchem.aid:1645877 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 1645877, deposited by NCGC; assay type Confirmatory. Source outcome: Inconclusive. Source endpoint: Potency. call NOT_DETERMINED measurement type OTHER value 8.9285 units uM
Primary qHTS for inhibitors of nuclear receptor binding SET domain protein 2 (NSD2) in an RCH-ACV wild type WT cells (2C)	OTHER 8.9285 uM; NOT_DETERMINED	UniProtKB:O96028	pubchem.aid:1645877 assay Primary qHTS for inhibitors of nuclear receptor binding SET domain protein 2 (NSD2) in an RCH-ACV wild type WT cells (2C) evidence reference pubchem.aid:1645877 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 1645877, deposited by NCGC; assay type Confirmatory. Source outcome: Inconclusive. Source endpoint: Potency. call NOT_DETERMINED measurement type OTHER value 8.9285 units uM target enzyme UniProtKB:O96028
Primary redox qHTS assay for identification of artifact compounds.	OTHER 13.0299 uM; NOT_DETERMINED	Not recorded	pubchem.aid:1845223 assay Primary redox qHTS assay for identification of artifact compounds. evidence reference pubchem.aid:1845223 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 1845223, deposited by NCGC; assay type Confirmatory. Source outcome: Inconclusive. Source endpoint: Potency. call NOT_DETERMINED measurement type OTHER value 13.0299 units uM
Viability qHTS for spleen associated tyrosine kinase inhibitor (SYKi) drug resistant MV4-11 cells	OTHER 0.2516 uM; NOT_DETERMINED	Not recorded	pubchem.aid:1963824 assay Viability qHTS for spleen associated tyrosine kinase inhibitor (SYKi) drug resistant MV4-11 cells evidence reference pubchem.aid:1963824 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 1963824, deposited by NCGC; assay type Confirmatory. Source outcome: Inconclusive. Source endpoint: Potency. call NOT_DETERMINED measurement type OTHER value 0.2516 units uM
Viability qHTS for spleen associated tyrosine kinase inhibitor (SYKi) drug resistant MV4-11 cells	OTHER 0.2516 uM; NOT_DETERMINED	UniProtKB:P43405	pubchem.aid:1963824 assay Viability qHTS for spleen associated tyrosine kinase inhibitor (SYKi) drug resistant MV4-11 cells evidence reference pubchem.aid:1963824 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 1963824, deposited by NCGC; assay type Confirmatory. Source outcome: Inconclusive. Source endpoint: Potency. call NOT_DETERMINED measurement type OTHER value 0.2516 units uM target enzyme UniProtKB:P43405

Explore across X-Mech

AntibioticMech (fumiquinazoline D) ↗ MediaIngredientMech (naturalproductmech:mibig-e85e28c3e4) ↗ TaxonMech: Aspergillus fumigatus Af293 (NCBITaxon:330879) ↗ PathwayMech (mibig:BGC0000355) ↗

Provenance

Source concept	Source	Version
BGC0000355	MIBIG	5

This page is generated from data/natural_products/alkaloids/fumiquinazoline-d.yaml, which is generated from the committed inventories. Neither is edited by hand.