fumiquinazoline D
naturalproductmech:mibig-e85e28c3e4 MINTED SEEDED enzyme inhibitor
Structure
| Standard InChIKey | YYLAARMDRFESOL-CVAYNVNESA-N |
|---|---|
| SMILES | C[C@H]1C(=O)N2[C@@H]3N1[C@]4(C5=NC6=CC=CC=C6C(=O)N5[C@H](C[C@@]3(C7=CC=CC=C72)O)C(=O)N4)C |
| Stereochemistry | fully defined |
| Cross-references | pubchem:9980845 |
Filing pathway
Alkaloids — computed by NPClassifier npclassifier.gnps2.org@2026-09-07, which is why it is pinned rather than recomputed. The gene cluster's asserted class is nrps, from MIBiG.
Producer organisms 1
A claim that this taxon makes the compound. The basis says what the evidence addressed — a knockout and a database assertion are not the same claim.
| Taxon | Basis | Cluster | Evidence |
|---|---|---|---|
| Aspergillus fumigatus Af293 NCBITaxon:330879 |
BGC_CHARACTERIZED | mibig:BGC0000355 | PMID:21899262 |
Occurrences 2
Somebody found the compound in this organism and cited it. That is not a claim that the organism makes it, and nothing here promotes one to the other.
| Taxon | Source | Reference |
|---|---|---|
| Aspergillus fumigatus NCBITaxon:746128 |
LOTUS | DOI:10.1021/JF300146N |
| Aspergillus fumigatus NCBITaxon:746128 |
LOTUS | DOI:10.1039/P19950002345 |
Biosynthetic gene clusters 1
| Accession | Host | Locus evidence | Genome |
|---|---|---|---|
| mibig:BGC0000355 | Aspergillus fumigatus Af293 NCBITaxon:330879 |
CLUSTER_DEMONSTRATED | genbank:CM000174.1 |
A locus claim and a taxon claim are different questions. Heterologous expression settles the first and leaves the second where the isolation report left it.
Bioactivities 5
| Assay | Result | Reference |
|---|---|---|
| Primary qHTS for inhibitors of nuclear receptor binding SET domain protein 2 (NSD2) in an RCH-ACV wild type WT cells (2C) | 8.9285 uM | pubchem.aid:1645877 |
| Primary qHTS for inhibitors of nuclear receptor binding SET domain protein 2 (NSD2) in an RCH-ACV wild type WT cells (2C) | 8.9285 uM | pubchem.aid:1645877 |
| Primary redox qHTS assay for identification of artifact compounds. | 13.0299 uM | pubchem.aid:1845223 |
| Viability qHTS for spleen associated tyrosine kinase inhibitor (SYKi) drug resistant MV4-11 cells | 0.2516 uM | pubchem.aid:1963824 |
| Viability qHTS for spleen associated tyrosine kinase inhibitor (SYKi) drug resistant MV4-11 cells | 0.2516 uM | pubchem.aid:1963824 |
Provenance
| Source concept | Source | Version |
|---|---|---|
| BGC0000355 | MIBIG | 5 |
This page is generated from data/natural_products/alkaloids/fumiquinazoline-d.yaml, which is generated from the committed inventories. Neither is edited by hand.