gilvusmycin
CHEBI:65964 EXACT SEEDED antimicrobial unspecified
An antibiotic isolated from the culture broth of Streptomyces sp. QM16 with potent cytotoxic activity against the human tumor cells.
Structure
| Standard InChIKey | XUBJLJZOSKJNMY-UHFFFAOYSA-N |
|---|---|
| SMILES | COC1=C(O)C2=C(CCN2C(C)=O)C2=C1NC(=C2)C(=O)N1CCC2=C1C(O)=C(OC)C1=C2C=C(N1)C(=O)N1CC2CC22C1=CC(=O)C1=C2C(C)=CN1 |
| Stereochemistry | undefined stereocentres — the InChIKey does not distinguish this compound from its stereoisomers |
| Cross-references | npatlas:NPA01823 |
Filing pathway
Alkaloids — computed by NPClassifier npclassifier.gnps2.org@2026-09-07, which is why it is pinned rather than recomputed. The gene cluster's asserted class is other, from MIBiG.
Producer organisms 1
A claim that this taxon makes the compound. The basis says what the evidence addressed — a knockout and a database assertion are not the same claim.
| Taxon | Basis | Cluster | Evidence |
|---|---|---|---|
| Streptomyces sp. NRRL B-1347 NCBITaxon:1476877 |
SOURCE_ASSERTION | mibig:BGC0001607 | PMID:29659660 |
Occurrences 2
Somebody found the compound in this organism and cited it. That is not a claim that the organism makes it, and nothing here promotes one to the other.
| Taxon | Source | Reference |
|---|---|---|
| Streptomyces NCBITaxon:1883 |
LOTUS | DOI:10.7164/ANTIBIOTICS.52.263 |
| Streptomyces sp. NCBITaxon:1931 |
CHEBI | PMID:10348041 |
Biosynthetic gene clusters 1
| Accession | Host | Locus evidence | Genome |
|---|---|---|---|
| mibig:BGC0001607 | Streptomyces sp. NRRL B-1347 NCBITaxon:1476877 |
CLUSTER_UNSTATED | genbank:NZ_JOJM01000053.1 |
A locus claim and a taxon claim are different questions. Heterologous expression settles the first and leaves the second where the isolation report left it.
Elsewhere in the fleet
- AntibioticMech — CHEBI:65964 (same structure, same inchikey)
Provenance
| Source concept | Source | Version |
|---|---|---|
| BGC0001607 | MIBIG | 5 |
| CHEBI:65964 | CHEBI | 3-star |
This page is generated from data/natural_products/alkaloids/gilvusmycin.yaml, which is generated from the committed inventories. Neither is edited by hand.