NaturalProductMech

Browse · Alkaloids · K-252a

K-252a

naturalproductmech:mibig-6af212b9a4 MINTED SEEDED cytotoxicenzyme inhibitor

Grounding review: No 3-star ChEBI entry shares this structure, so the record keeps a content-hashed identifier.
What these status tags mean

Curation status describes a workflow state. SEEDED means the record entered through the source-seeding workflow; it does not imply that no later curation occurred. PROPOSED marks an addition awaiting review; REVIEWED records curator sign-off on identity, structure, filing class and producer claims; DEPRECATED retains a superseded or out-of-scope record. These are workflow decisions, not independently verified human review. Agent-assisted contributions may appear in the record history.

Grounding describes the identifier mapping: EXACT uses an ontology identity asserted by the source; MINTED keeps a local identifier when no defensible ontology identity is available; REVIEW_NEEDED flags an exact structure whose ontology identity needs adjudication. The grounding note retains any unresolved alternatives. These tags do not establish the strength of producer or activity evidence.

Structure

Standard InChIKeyKOZFSFOOLUUIGY-BLIZRMSTSA-N
SMILES[H][C@]12C[C@@](O)(C(=O)OC)[C@](C)(O1)N1C3=C(C=CC=C3)C3=C1C1=C(C4=C(C=CC=C4)N21)C1=C3CNC1=O
Stereochemistryfully defined
Cross-referencespubchem:3035817, npatlas:NPA02183

Filing pathway

Alkaloids — computed by NPClassifier npclassifier.gnps2.org@2026-09-07, which is why it is pinned rather than recomputed. The gene cluster's asserted class is other, from MIBiG.

Producer organisms 1

A claim that this taxon makes the compound. The basis says what the evidence addressed — a knockout and a database assertion are not the same claim.

TaxonBasisClusterEvidence
Nonomuraea longicatena
NCBITaxon:83682		 SOURCE_ASSERTION mibig:BGC0000813 DOI:10.7164/antibiotics.39.1059

Occurrences 2

Somebody found the compound in this organism and cited it. That is not a claim that the organism makes it, and nothing here promotes one to the other.

TaxonSourceReference
Nocardiopsis
NCBITaxon:2013		 LOTUS DOI:10.7164/ANTIBIOTICS.39.1059
Streptomyces sanyensis
NCBITaxon:568869		 LOTUS DOI:10.3390/MD11020466

Biosynthetic gene clusters 1

AccessionHostLocus evidenceGenome
mibig:BGC0000813 Nonomuraea longicatena
NCBITaxon:83682 		CLUSTER_UNSTATED genbank:DQ399653.1

A locus claim and a taxon claim are different questions. Heterologous expression settles the first and leaves the second where the isolation report left it.

Mechanism & Biosynthesis Overview

PRODUCERS & OCCURRENCE 1 producer (0 causal) 2 cited occurrences BIOSYNTHETIC LOCUS 1 gene cluster 0 curated pathway steps NATURAL PRODUCT K-252a naturalproductmech:mibig-6af212b9a4 Alkaloids TARGETS & BIOACTIVITY 0 molecular targets 25 bioactivities · 3 graphs

Causal graph — bioactivity 2 nodes, 1 edge

K-252a inhibits human serine/threonine-protein kinase PIM1.

SubjectPredicateObjectNotesEvidence
K-252a inhibits human serine/threonine-protein kinase PIM1 BindingDB-deposited PubChem BioAssay AID 1796959 maps this exact Standard InChIKey to an active 0.15 uM IC50 kinase measurement against UniProtKB:P11309; P11309 resolves in UniProtKB to the human PIM1 gene product.
DOI:10.1074/jbc.M413155200
  • reference
    DOI:10.1074/jbc.M413155200
    evidence type
    PRIMARY_EXPERIMENT
    snippet
    Pim-1 Ligand-bound Structures Reveal the Mechanism of Serine/Threonine Kinase Inhibition
    notes
    PubChem BioAssay AID 1796959 was deposited by BindingDB for PMID 15657054 and reports active K-252a inhibition of human PIM1.

Every edge carries its own citation; an uncited edge is refused by the corpus tests.

Causal graph — bioactivity 4 nodes, 3 edges

K-252a inhibits human mixed lineage kinases 1, 2, and 3.

SubjectPredicateObjectNotesEvidence
K-252a inhibits human mixed lineage kinase 1 BindingDB-deposited PubChem BioAssay AID 1797180 maps this exact Standard InChIKey to an active 0.022 uM IC50 measurement against UniProtKB:P80192; P80192 resolves in UniProtKB to the reviewed human MAP3K9/MLK1 gene product.
DOI:10.1021/jm051074u
  • reference
    DOI:10.1021/jm051074u
    evidence type
    PRIMARY_EXPERIMENT
    snippet
    Synthesis and mixed lineage kinase activity of pyrrolocarbazole and isoindolone analogs of (+)K-252a
    notes
    PubChem BioAssay AID 1797180 was deposited by BindingDB for PMID 17266195 and reports active K-252a inhibition of human MAP3K9/MLK1.
K-252a inhibits human mixed lineage kinase 2 BindingDB-deposited PubChem BioAssay AID 1797180 maps this exact Standard InChIKey to an active 0.045 uM IC50 measurement against UniProtKB:Q02779; Q02779 resolves in UniProtKB to the reviewed human MAP3K10/MLK2 gene product.
DOI:10.1021/jm051074u
  • reference
    DOI:10.1021/jm051074u
    evidence type
    PRIMARY_EXPERIMENT
    snippet
    Synthesis and mixed lineage kinase activity of pyrrolocarbazole and isoindolone analogs of (+)K-252a
    notes
    PubChem BioAssay AID 1797180 was deposited by BindingDB for PMID 17266195 and reports active K-252a inhibition of human MAP3K10/MLK2.
K-252a inhibits human mixed lineage kinase 3 BindingDB-deposited PubChem BioAssay AID 1797180 maps this exact Standard InChIKey to an active 0.013 uM IC50 measurement against UniProtKB:Q16584; Q16584 resolves in UniProtKB to the reviewed human MAP3K11/MLK3 gene product.
DOI:10.1021/jm051074u
  • reference
    DOI:10.1021/jm051074u
    evidence type
    PRIMARY_EXPERIMENT
    snippet
    Synthesis and mixed lineage kinase activity of pyrrolocarbazole and isoindolone analogs of (+)K-252a
    notes
    PubChem BioAssay AID 1797180 was deposited by BindingDB for PMID 17266195 and reports active K-252a inhibition of human MAP3K11/MLK3.

Every edge carries its own citation; an uncited edge is refused by the corpus tests.

Causal graph — bioactivity 7 nodes, 6 edges

K-252a inhibits human CDK4-cyclin D1 and CDK2-cyclin E1 protein complexes.

SubjectPredicateObjectNotesEvidence
K-252a inhibits human CDK4-cyclin D1 complex BindingDB-deposited PubChem BioAssay AID 1795945 maps this exact Standard InChIKey to active 0.03 uM IC50 measurements against UniProtKB:P11802 and UniProtKB:P24385; UniProt cross-references for these reviewed human CDK4 and cyclin D1 accessions place both in ComplexPortal:CPX-2010.
DOI:10.1016/s0960-894x(03)00792-3
  • reference
    DOI:10.1016/s0960-894x(03)00792-3
    evidence type
    PRIMARY_EXPERIMENT
    snippet
    Studies on cyclin-dependent kinase inhibitors: indolo-[2,3-a]pyrrolo[3,4-c]carbazoles versus bis-indolylmaleimides
    notes
    PubChem BioAssay AID 1795945 was deposited by BindingDB for PMID 14552792 and reports active K-252a inhibition of human CDK4/cyclin D1.
K-252a inhibits human CDK2-cyclin E1 complex BindingDB-deposited PubChem BioAssay AID 1795945 maps this exact Standard InChIKey to active 0.26 uM IC50 measurements against UniProtKB:P24864 and UniProtKB:P24941; UniProt cross-references for these reviewed human cyclin E1 and CDK2 accessions place both in ComplexPortal:CPX-2015.
DOI:10.1016/s0960-894x(03)00792-3
  • reference
    DOI:10.1016/s0960-894x(03)00792-3
    evidence type
    PRIMARY_EXPERIMENT
    snippet
    Studies on cyclin-dependent kinase inhibitors: indolo-[2,3-a]pyrrolo[3,4-c]carbazoles versus bis-indolylmaleimides
    notes
    PubChem BioAssay AID 1795945 was deposited by BindingDB for PMID 14552792 and reports active K-252a inhibition of human CDK2/cyclin E1.
human cyclin-dependent kinase 4 (CDK4) is a subunit of human CDK4-cyclin D1 complex ComplexPortal:CPX-2010 (human CDK4-cyclin D1 complex) lists UniProtKB:P11802 (human cyclin-dependent kinase 4 (CDK4)) as a constituent polypeptide subunit.
https://www.ebi.ac.uk/complexportal/complex/CPX-2010
https://www.uniprot.org/uniprotkb/P11802
  • reference
    https://www.ebi.ac.uk/complexportal/complex/CPX-2010
    evidence type
    DATABASE_ASSERTION
    retrieved on
    2026-10-17
    notes
    ComplexPortal CPX-2010 defines human CDK4-cyclin D1 complex with subunit UniProtKB:P11802.
  • reference
    https://www.uniprot.org/uniprotkb/P11802
    evidence type
    DATABASE_ASSERTION
    retrieved on
    2026-10-17
    notes
    Reviewed human Swiss-Prot entry UniProtKB:P11802 (human cyclin-dependent kinase 4 (CDK4)).
human G1/S-specific cyclin-D1 (CCND1) is a subunit of human CDK4-cyclin D1 complex ComplexPortal:CPX-2010 (human CDK4-cyclin D1 complex) lists UniProtKB:P24385 (human G1/S-specific cyclin-D1 (CCND1)) as a constituent polypeptide subunit.
https://www.ebi.ac.uk/complexportal/complex/CPX-2010
https://www.uniprot.org/uniprotkb/P24385
  • reference
    https://www.ebi.ac.uk/complexportal/complex/CPX-2010
    evidence type
    DATABASE_ASSERTION
    retrieved on
    2026-10-17
    notes
    ComplexPortal CPX-2010 defines human CDK4-cyclin D1 complex with subunit UniProtKB:P24385.
  • reference
    https://www.uniprot.org/uniprotkb/P24385
    evidence type
    DATABASE_ASSERTION
    retrieved on
    2026-10-17
    notes
    Reviewed human Swiss-Prot entry UniProtKB:P24385 (human G1/S-specific cyclin-D1 (CCND1)).
human cyclin-dependent kinase 2 (CDK2) is a subunit of human CDK2-cyclin E1 complex ComplexPortal:CPX-2015 (human CDK2-cyclin E1 complex) lists UniProtKB:P24941 (human cyclin-dependent kinase 2 (CDK2)) as a constituent polypeptide subunit.
https://www.ebi.ac.uk/complexportal/complex/CPX-2015
https://www.uniprot.org/uniprotkb/P24941
  • reference
    https://www.ebi.ac.uk/complexportal/complex/CPX-2015
    evidence type
    DATABASE_ASSERTION
    retrieved on
    2026-10-17
    notes
    ComplexPortal CPX-2015 defines human CDK2-cyclin E1 complex with subunit UniProtKB:P24941.
  • reference
    https://www.uniprot.org/uniprotkb/P24941
    evidence type
    DATABASE_ASSERTION
    retrieved on
    2026-10-17
    notes
    Reviewed human Swiss-Prot entry UniProtKB:P24941 (human cyclin-dependent kinase 2 (CDK2)).
human G1/S-specific cyclin-E1 (CCNE1) is a subunit of human CDK2-cyclin E1 complex ComplexPortal:CPX-2015 (human CDK2-cyclin E1 complex) lists UniProtKB:P24864 (human G1/S-specific cyclin-E1 (CCNE1)) as a constituent polypeptide subunit.
https://www.ebi.ac.uk/complexportal/complex/CPX-2015
https://www.uniprot.org/uniprotkb/P24864
  • reference
    https://www.ebi.ac.uk/complexportal/complex/CPX-2015
    evidence type
    DATABASE_ASSERTION
    retrieved on
    2026-10-17
    notes
    ComplexPortal CPX-2015 defines human CDK2-cyclin E1 complex with subunit UniProtKB:P24864.
  • reference
    https://www.uniprot.org/uniprotkb/P24864
    evidence type
    DATABASE_ASSERTION
    retrieved on
    2026-10-17
    notes
    Reviewed human Swiss-Prot entry UniProtKB:P24864 (human G1/S-specific cyclin-E1 (CCNE1)).

Every edge carries its own citation; an uncited edge is refused by the corpus tests.

Bioactivities 25

Entries preserve source qualifiers, targets and evidence. Repeated assay names or values are not independent replications; inspect source detail for differences.

AssayResultTarget enzymeSource detail
CDK Kinase Inhibition Assay from Article 10.1016/s0960-894x(03)00792-3: "Studies on cyclin-dependent kinase inhibitors: indolo-[2,3-a]pyrrolo[3,4-c]carbazoles versus bis-indolylmaleimides."IC50 0.03 uM; ACTIVEUniProtKB:P11802
PMID:14552792
assay
CDK Kinase Inhibition Assay from Article 10.1016/s0960-894x(03)00792-3: "Studies on cyclin-dependent kinase inhibitors: indolo-[2,3-a]pyrrolo[3,4-c]carbazoles versus bis-indolylmaleimides."
evidence
  • reference
    PMID:14552792
    evidence type
    DATABASE_ASSERTION
    notes
    PubChem BioAssay AID 1795945, deposited by BindingDB; assay type Confirmatory.
call
ACTIVE
measurement type
IC50
value
0.03
units
uM
target enzyme
UniProtKB:P11802
CDK Kinase Inhibition Assay from Article 10.1016/s0960-894x(03)00792-3: "Studies on cyclin-dependent kinase inhibitors: indolo-[2,3-a]pyrrolo[3,4-c]carbazoles versus bis-indolylmaleimides."IC50 0.03 uM; ACTIVEUniProtKB:P24385
PMID:14552792
assay
CDK Kinase Inhibition Assay from Article 10.1016/s0960-894x(03)00792-3: "Studies on cyclin-dependent kinase inhibitors: indolo-[2,3-a]pyrrolo[3,4-c]carbazoles versus bis-indolylmaleimides."
evidence
  • reference
    PMID:14552792
    evidence type
    DATABASE_ASSERTION
    notes
    PubChem BioAssay AID 1795945, deposited by BindingDB; assay type Confirmatory.
call
ACTIVE
measurement type
IC50
value
0.03
units
uM
target enzyme
UniProtKB:P24385
CDK Kinase Inhibition Assay from Article 10.1016/s0960-894x(03)00792-3: "Studies on cyclin-dependent kinase inhibitors: indolo-[2,3-a]pyrrolo[3,4-c]carbazoles versus bis-indolylmaleimides."IC50 0.26 uM; ACTIVEUniProtKB:P24864
PMID:14552792
assay
CDK Kinase Inhibition Assay from Article 10.1016/s0960-894x(03)00792-3: "Studies on cyclin-dependent kinase inhibitors: indolo-[2,3-a]pyrrolo[3,4-c]carbazoles versus bis-indolylmaleimides."
evidence
  • reference
    PMID:14552792
    evidence type
    DATABASE_ASSERTION
    notes
    PubChem BioAssay AID 1795945, deposited by BindingDB; assay type Confirmatory.
call
ACTIVE
measurement type
IC50
value
0.26
units
uM
target enzyme
UniProtKB:P24864
CDK Kinase Inhibition Assay from Article 10.1016/s0960-894x(03)00792-3: "Studies on cyclin-dependent kinase inhibitors: indolo-[2,3-a]pyrrolo[3,4-c]carbazoles versus bis-indolylmaleimides."IC50 0.26 uM; ACTIVEUniProtKB:P24941
PMID:14552792
assay
CDK Kinase Inhibition Assay from Article 10.1016/s0960-894x(03)00792-3: "Studies on cyclin-dependent kinase inhibitors: indolo-[2,3-a]pyrrolo[3,4-c]carbazoles versus bis-indolylmaleimides."
evidence
  • reference
    PMID:14552792
    evidence type
    DATABASE_ASSERTION
    notes
    PubChem BioAssay AID 1795945, deposited by BindingDB; assay type Confirmatory.
call
ACTIVE
measurement type
IC50
value
0.26
units
uM
target enzyme
UniProtKB:P24941
Experimentally measured binding affinity data (IC50) for protein-ligand complexes derived from PDBIC50 1 uM; ACTIVENot recorded
PMID:19008858
assay
Experimentally measured binding affinity data (IC50) for protein-ligand complexes derived from PDB
evidence
  • reference
    PMID:19008858
    evidence type
    DATABASE_ASSERTION
    notes
    PubChem BioAssay AID 977608, deposited by Shanghai Institute of Organic Chemistry; assay type Other. Target accession 3F69_A was left ungrounded because PubChem did not provide a UniProtKB accession.
call
ACTIVE
measurement type
IC50
value
1.0
units
uM
activity class
ENZYME_INHIBITOR
Experimentally measured binding affinity data (Kd) for protein-ligand complexes derived from PDBKD 0.01 uM; ACTIVENot recorded
PMID:14559966
assay
Experimentally measured binding affinity data (Kd) for protein-ligand complexes derived from PDB
evidence
  • reference
    PMID:14559966
    evidence type
    DATABASE_ASSERTION
    notes
    PubChem BioAssay AID 977611, deposited by Shanghai Institute of Organic Chemistry; assay type Other. Target accession 1R0P_A was left ungrounded because PubChem did not provide a UniProtKB accession.
call
ACTIVE
measurement type
KD
value
0.01
units
uM
activity class
ENZYME_INHIBITOR
Kinase Assay from Article 10.1074/jbc.M413155200: "Pim-1 ligand-bound structures reveal the mechanism of serine/threonine kinase inhibition by LY294002."IC50 0.15 uM; ACTIVEUniProtKB:P11309
PMID:15657054
assay
Kinase Assay from Article 10.1074/jbc.M413155200: "Pim-1 ligand-bound structures reveal the mechanism of serine/threonine kinase inhibition by LY294002."
evidence
  • reference
    PMID:15657054
    evidence type
    DATABASE_ASSERTION
    notes
    PubChem BioAssay AID 1796959, deposited by BindingDB; assay type Confirmatory.
call
ACTIVE
measurement type
IC50
value
0.15
units
uM
target enzyme
UniProtKB:P11309
Mixed-Lineage Kinase Assays from Article 10.1021/jm051074u: "Synthesis and mixed lineage kinase activity of pyrrolocarbazole and isoindolone analogs of (+)K-252a."IC50 0.022 uM; ACTIVEUniProtKB:P80192
PMID:17266195
assay
Mixed-Lineage Kinase Assays from Article 10.1021/jm051074u: "Synthesis and mixed lineage kinase activity of pyrrolocarbazole and isoindolone analogs of (+)K-252a."
evidence
  • reference
    PMID:17266195
    evidence type
    DATABASE_ASSERTION
    notes
    PubChem BioAssay AID 1797180, deposited by BindingDB; assay type Confirmatory.
call
ACTIVE
measurement type
IC50
value
0.022
units
uM
target enzyme
UniProtKB:P80192
Mixed-Lineage Kinase Assays from Article 10.1021/jm051074u: "Synthesis and mixed lineage kinase activity of pyrrolocarbazole and isoindolone analogs of (+)K-252a."IC50 0.045 uM; ACTIVEUniProtKB:Q02779
PMID:17266195
assay
Mixed-Lineage Kinase Assays from Article 10.1021/jm051074u: "Synthesis and mixed lineage kinase activity of pyrrolocarbazole and isoindolone analogs of (+)K-252a."
evidence
  • reference
    PMID:17266195
    evidence type
    DATABASE_ASSERTION
    notes
    PubChem BioAssay AID 1797180, deposited by BindingDB; assay type Confirmatory.
call
ACTIVE
measurement type
IC50
value
0.045
units
uM
target enzyme
UniProtKB:Q02779
Mixed-Lineage Kinase Assays from Article 10.1021/jm051074u: "Synthesis and mixed lineage kinase activity of pyrrolocarbazole and isoindolone analogs of (+)K-252a."IC50 0.013 uM; ACTIVEUniProtKB:Q16584
PMID:17266195
assay
Mixed-Lineage Kinase Assays from Article 10.1021/jm051074u: "Synthesis and mixed lineage kinase activity of pyrrolocarbazole and isoindolone analogs of (+)K-252a."
evidence
  • reference
    PMID:17266195
    evidence type
    DATABASE_ASSERTION
    notes
    PubChem BioAssay AID 1797180, deposited by BindingDB; assay type Confirmatory.
call
ACTIVE
measurement type
IC50
value
0.013
units
uM
target enzyme
UniProtKB:Q16584
PDGFRα Kinase Assay from US Patent US20250129067: "PLATELET-DERIVED GROWTH FACTOR RECEPTOR (PDGFR) ALPHA INHIBITORS AND USES THEREOF"IC50 0.427 uM; ACTIVEUniProtKB:P16234
pubchem.aid:2061288
assay
PDGFRα Kinase Assay from US Patent US20250129067: "PLATELET-DERIVED GROWTH FACTOR RECEPTOR (PDGFR) ALPHA INHIBITORS AND USES THEREOF"
evidence
  • reference
    pubchem.aid:2061288
    evidence type
    DATABASE_ASSERTION
    notes
    PubChem BioAssay AID 2061288, deposited by BindingDB; assay type Confirmatory.
call
ACTIVE
measurement type
IC50
value
0.427
units
uM
target enzyme
UniProtKB:P16234
Experimentally measured binding affinity data derived from PDBACTIVENot recorded
PMID:14559966
assay
Experimentally measured binding affinity data derived from PDB
evidence
  • reference
    PMID:14559966
    evidence type
    DATABASE_ASSERTION
    notes
    PubChem BioAssay AID 1811, deposited by Shanghai Institute of Organic Chemistry; assay type Other. Target accession 1R0P_A was left ungrounded because PubChem did not provide a UniProtKB accession.
call
ACTIVE
activity class
ENZYME_INHIBITOR
NCI human tumor cell line growth inhibition assay. Data for the 786-0 Non-Small Cell Lung cell line, single concentrationACTIVENot recorded
pubchem.aid:1794775
assay
NCI human tumor cell line growth inhibition assay. Data for the 786-0 Non-Small Cell Lung cell line, single concentration
evidence
  • reference
    pubchem.aid:1794775
    evidence type
    DATABASE_ASSERTION
    notes
    PubChem BioAssay AID 1794775, deposited by DTP/NCI; assay type Screening.
call
ACTIVE
activity class
CYTOTOXIC
NCI human tumor cell line growth inhibition assay. Data for the 786-0 Renal cell lineACTIVENot recorded
pubchem.aid:137
assay
NCI human tumor cell line growth inhibition assay. Data for the 786-0 Renal cell line
evidence
  • reference
    pubchem.aid:137
    evidence type
    DATABASE_ASSERTION
    notes
    PubChem BioAssay AID 137, deposited by DTP/NCI; assay type Confirmatory.
call
ACTIVE
activity class
CYTOTOXIC
NCI human tumor cell line growth inhibition assay. Data for the A498 Non-Small Cell Lung cell line, single concentrationACTIVENot recorded
pubchem.aid:1794774
assay
NCI human tumor cell line growth inhibition assay. Data for the A498 Non-Small Cell Lung cell line, single concentration
evidence
  • reference
    pubchem.aid:1794774
    evidence type
    DATABASE_ASSERTION
    notes
    PubChem BioAssay AID 1794774, deposited by DTP/NCI; assay type Screening.
call
ACTIVE
activity class
CYTOTOXIC
NCI human tumor cell line growth inhibition assay. Data for the A498 Renal cell lineACTIVENot recorded
pubchem.aid:129
assay
NCI human tumor cell line growth inhibition assay. Data for the A498 Renal cell line
evidence
  • reference
    pubchem.aid:129
    evidence type
    DATABASE_ASSERTION
    notes
    PubChem BioAssay AID 129, deposited by DTP/NCI; assay type Confirmatory.
call
ACTIVE
activity class
CYTOTOXIC
NCI human tumor cell line growth inhibition assay. Data for the A549/ATCC Non-Small Cell Lung cell lineACTIVENot recorded
pubchem.aid:19
assay
NCI human tumor cell line growth inhibition assay. Data for the A549/ATCC Non-Small Cell Lung cell line
evidence
  • reference
    pubchem.aid:19
    evidence type
    DATABASE_ASSERTION
    notes
    PubChem BioAssay AID 19, deposited by DTP/NCI; assay type Confirmatory.
call
ACTIVE
activity class
CYTOTOXIC
NCI human tumor cell line growth inhibition assay. Data for the A549/ATCC Non-Small Cell Lung cell line, single concentrationACTIVENot recorded
pubchem.aid:1794740
assay
NCI human tumor cell line growth inhibition assay. Data for the A549/ATCC Non-Small Cell Lung cell line, single concentration
evidence
  • reference
    pubchem.aid:1794740
    evidence type
    DATABASE_ASSERTION
    notes
    PubChem BioAssay AID 1794740, deposited by DTP/NCI; assay type Screening.
call
ACTIVE
activity class
CYTOTOXIC
NCI human tumor cell line growth inhibition assay. Data for the ACHN Non-Small Cell Lung cell line, single concentrationACTIVENot recorded
pubchem.aid:1794771
assay
NCI human tumor cell line growth inhibition assay. Data for the ACHN Non-Small Cell Lung cell line, single concentration
evidence
  • reference
    pubchem.aid:1794771
    evidence type
    DATABASE_ASSERTION
    notes
    PubChem BioAssay AID 1794771, deposited by DTP/NCI; assay type Screening.
call
ACTIVE
activity class
CYTOTOXIC
NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell lineACTIVENot recorded
pubchem.aid:139
assay
NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line
evidence
  • reference
    pubchem.aid:139
    evidence type
    DATABASE_ASSERTION
    notes
    PubChem BioAssay AID 139, deposited by DTP/NCI; assay type Confirmatory.
call
ACTIVE
activity class
CYTOTOXIC
NCI human tumor cell line growth inhibition assay. Data for the BT-549 Breast cell lineACTIVENot recorded
pubchem.aid:89
assay
NCI human tumor cell line growth inhibition assay. Data for the BT-549 Breast cell line
evidence
  • reference
    pubchem.aid:89
    evidence type
    DATABASE_ASSERTION
    notes
    PubChem BioAssay AID 89, deposited by DTP/NCI; assay type Confirmatory.
call
ACTIVE
activity class
CYTOTOXIC
NCI human tumor cell line growth inhibition assay. Data for the BT-549 Non-Small Cell Lung cell line, single concentrationACTIVENot recorded
pubchem.aid:1794793
assay
NCI human tumor cell line growth inhibition assay. Data for the BT-549 Non-Small Cell Lung cell line, single concentration
evidence
  • reference
    pubchem.aid:1794793
    evidence type
    DATABASE_ASSERTION
    notes
    PubChem BioAssay AID 1794793, deposited by DTP/NCI; assay type Screening.
call
ACTIVE
activity class
CYTOTOXIC
NCI human tumor cell line growth inhibition assay. Data for the CAKI-1 Non-Small Cell Lung cell line, single concentrationACTIVENot recorded
pubchem.aid:1794772
assay
NCI human tumor cell line growth inhibition assay. Data for the CAKI-1 Non-Small Cell Lung cell line, single concentration
evidence
  • reference
    pubchem.aid:1794772
    evidence type
    DATABASE_ASSERTION
    notes
    PubChem BioAssay AID 1794772, deposited by DTP/NCI; assay type Screening.
call
ACTIVE
activity class
CYTOTOXIC
NCI human tumor cell line growth inhibition assay. Data for the CAKI-1 Renal cell lineACTIVENot recorded
pubchem.aid:131
assay
NCI human tumor cell line growth inhibition assay. Data for the CAKI-1 Renal cell line
evidence
  • reference
    pubchem.aid:131
    evidence type
    DATABASE_ASSERTION
    notes
    PubChem BioAssay AID 131, deposited by DTP/NCI; assay type Confirmatory.
call
ACTIVE
activity class
CYTOTOXIC
NCI human tumor cell line growth inhibition assay. Data for the CCRF-CEM Leukemia cell lineACTIVENot recorded
pubchem.aid:119
assay
NCI human tumor cell line growth inhibition assay. Data for the CCRF-CEM Leukemia cell line
evidence
  • reference
    pubchem.aid:119
    evidence type
    DATABASE_ASSERTION
    notes
    PubChem BioAssay AID 119, deposited by DTP/NCI; assay type Confirmatory.
call
ACTIVE
activity class
CYTOTOXIC
notes
90 further PubChem assay results are in data/raw/pubchem_bioassay.tsv but not written here.

Explore across X-Mech

AntibioticMech (K-252a) ↗ MediaIngredientMech (naturalproductmech:mibig-6af212b9a4) ↗ TaxonMech: Nonomuraea longicatena (NCBITaxon:83682) ↗ PathwayMech (mibig:BGC0000813) ↗

Provenance

Source conceptSourceVersion
BGC0000813MIBIG3

This page is generated from data/natural_products/alkaloids/k-252a-2.yaml, which is generated from the committed inventories. Neither is edited by hand.