K-252a
CHEBI:43616 EXACT SEEDED antimicrobial unspecified
A organic heterooctacyclic compound that is a potent inhibitor of protein kinase C and is isolated from Nocardiopsis sp K-252a
Structure
| Standard InChIKey | KOZFSFOOLUUIGY-SOLYNIJKSA-N |
|---|---|
| SMILES | C[C@@]12[C@](C[C@@H](O1)N3C4=CC=CC=C4C5=C6C(=C7C8=CC=CC=C8N2C7=C53)CNC6=O)(C(=O)OC)O |
| Stereochemistry | fully defined |
| Cross-references | pubchem:3035817 |
Filing pathway
Alkaloids — computed by NPClassifier npclassifier.gnps2.org@2026-09-07, which is why it is pinned rather than recomputed. The gene cluster's asserted class is other, from MIBiG.
Producer organisms 1
A claim that this taxon makes the compound. The basis says what the evidence addressed — a knockout and a database assertion are not the same claim.
| Taxon | Basis | Cluster | Evidence |
|---|---|---|---|
| Nonomuraea longicatena NCBITaxon:83682 |
SOURCE_ASSERTION | mibig:BGC0000814 | DOI:10.7164/antibiotics.39.1059 |
Occurrences 5
Somebody found the compound in this organism and cited it. That is not a claim that the organism makes it, and nothing here promotes one to the other.
| Taxon | Source | Reference |
|---|---|---|
| Actinomadura NCBITaxon:1988 |
LOTUS | DOI:10.7164/ANTIBIOTICS.38.1437 |
| Nocardiopsis NCBITaxon:2013 |
LOTUS | DOI:10.7164/ANTIBIOTICS.39.1059 |
| Streptomyces longisporoflavus NCBITaxon:28044 |
LOTUS | DOI:10.7164/ANTIBIOTICS.49.1060 |
| Streptomyces longisporoflavus NCBITaxon:28044 |
LOTUS | DOI:10.7164/ANTIBIOTICS.49.519 |
| Nocardiopsis sp. K-252a NCBITaxon:310350 |
CHEBI | PMID:3759657 |
Biosynthetic gene clusters 1
| Accession | Host | Locus evidence | Genome |
|---|---|---|---|
| mibig:BGC0000814 | Nonomuraea longicatena NCBITaxon:83682 |
CLUSTER_UNSTATED | genbank:FJ031030.1 |
A locus claim and a taxon claim are different questions. Heterologous expression settles the first and leaves the second where the isolation report left it.
Elsewhere in the fleet
- AntibioticMech — CHEBI:43616 (same structure, same inchikey)
Provenance
| Source concept | Source | Version |
|---|---|---|
| BGC0000814 | MIBIG | 3 |
| CHEBI:43616 | CHEBI | 3-star |
This page is generated from data/natural_products/alkaloids/k-252a.yaml, which is generated from the committed inventories. Neither is edited by hand.