methylarcyriarubin
naturalproductmech:mibig-75c7941688 MINTED SEEDED
Structure
| Standard InChIKey | SWAWYMIKGOHZMR-UHFFFAOYSA-N |
|---|---|
| SMILES | O=C(N1C)C(C2=CNC3=CC=CC=C32)=C(C4=CNC5=CC=CC=C54)C1=O |
| Stereochemistry | fully defined |
Filing pathway
Alkaloids — computed by NPClassifier npclassifier.gnps2.org@2026-09-07, which is why it is pinned rather than recomputed. The gene cluster's asserted class is other, from MIBiG.
Producer organisms 0
None. The compound has a characterized gene cluster whose host NCBI does not name, which for an uncultured symbiont is the honest state — see the discussion below.
Occurrences 0
None cited.
Biosynthetic gene clusters 1
| Accession | Host | Locus evidence | Genome |
|---|---|---|---|
| mibig:BGC0000817 | not named | CLUSTER_CORRELATED | genbank:KF551863.1 |
A locus claim and a taxon claim are different questions. Heterologous expression settles the first and leaves the second where the isolation report left it.
Molecular targets 2
| Target | Assay organism | Measurement | Reference |
|---|---|---|---|
| Protein kinase C beta type UniProtKB:P68403 |
Rattus norvegicus NCBITaxon:10116 |
IC50 100000 nM | PMID:1732526 |
| cAMP-dependent protein kinase catalytic subunit alpha UniProtKB:P00517 |
Bos taurus NCBITaxon:9913 |
IC50 50000 nM | PMID:1874734 |
Open questions 1
unnamed-producer — No producer claim is written from BGC0000817, which gives NCBITaxon:77133 (uncultured bacterium — shared by every unplaced bacterium), because the taxon names no single organism. The cluster is kept: a characterized locus is an origin assertion whether or not its host has a name, and for a compound from an uncultured symbiont that is the honest state. Name the producer if the primary literature does.
Provenance
| Source concept | Source | Version |
|---|---|---|
| BGC0000817 | MIBIG | 4 |
This page is generated from data/natural_products/alkaloids/methylarcyriarubin.yaml, which is generated from the committed inventories. Neither is edited by hand.