myxochelin A
naturalproductmech:mibig-b9324089ad MINTED SEEDED
Structure
| Standard InChIKey | WNBVGSNESTZACV-LBPRGKRZSA-N |
|---|---|
| SMILES | OC[C@H](CCCCNC(=O)C1=CC=CC(O)=C1O)NC(=O)C1=CC=CC(O)=C1O |
| Stereochemistry | fully defined |
| Cross-references | npatlas:NPA02219, pubchem:16093504, npatlas:NPA002219 |
Filing pathway
Alkaloids — computed by NPClassifier npclassifier.gnps2.org@2026-09-07, which is why it is pinned rather than recomputed. The gene cluster's asserted class is nrps, pks, from MIBiG.
Producer organisms 4
A claim that this taxon makes the compound. The basis says what the evidence addressed — a knockout and a database assertion are not the same claim.
| Taxon | Basis | Cluster | Evidence |
|---|---|---|---|
| Stigmatella aurantiaca Sg a15 NCBITaxon:675526 |
SOURCE_ASSERTION | mibig:BGC0001345 | PMID:11562468 |
| Archangium violaceum NCBITaxon:83451 |
SOURCE_ASSERTION | mibig:BGC0002324 | PMID:34623817 |
| Pseudoalteromonas piscicida NCBITaxon:43662 |
SOURCE_ASSERTION | mibig:BGC0002491 | PMID:30217842 |
| Myxococcus xanthus DK 1622 NCBITaxon:246197 |
SOURCE_ASSERTION | mibig:BGC0002492 | PMID:30217842 |
Occurrences 3
Somebody found the compound in this organism and cited it. That is not a claim that the organism makes it, and nothing here promotes one to the other.
| Taxon | Source | Reference |
|---|---|---|
| Streptomyces albus NCBITaxon:1888 |
LOTUS | DOI:10.1093/FEMSLE/FNX155 |
| Angiococcus disciformis NCBITaxon:38 |
LOTUS | DOI:10.7164/ANTIBIOTICS.42.14 |
| Stigmatella aurantiaca NCBITaxon:41 |
LOTUS | DOI:10.1073/PNAS.201167098 |
Biosynthetic gene clusters 4
| Accession | Host | Locus evidence | Genome |
|---|---|---|---|
| mibig:BGC0001345 | Stigmatella aurantiaca Sg a15 NCBITaxon:675526 |
CLUSTER_UNSTATED | genbank:AF299336.1 |
| mibig:BGC0002324 | Archangium violaceum NCBITaxon:83451 |
CLUSTER_UNSTATED | genbank:CP069338.1 |
| mibig:BGC0002491 | Pseudoalteromonas piscicida NCBITaxon:43662 |
CLUSTER_DEMONSTRATED | genbank:JXXW01000072.1 |
| mibig:BGC0002492 | Myxococcus xanthus DK 1622 NCBITaxon:246197 |
CLUSTER_DEMONSTRATED | genbank:CP000113.1 |
A locus claim and a taxon claim are different questions. Heterologous expression settles the first and leaves the second where the isolation report left it.
Causal graph — bioactivity 2 nodes, 1 edges
Myxochelin A inhibits human 5-lipoxygenase in a 5-LO activity assay.
| Subject | Predicate | Object | Evidence |
|---|---|---|---|
| myxochelin A | inhibits | human 5-lipoxygenase | DOI:10.1002/cbic.201500446 |
Every edge carries its own citation; an uncited edge is refused by the corpus tests.
Bioactivities 1
| Assay | Result | Reference |
|---|---|---|
| 5-LO Activity Assay from Article 10.1002/cbic.201500446: "Harnessing Enzymatic Promiscuity in Myxochelin Biosynthesis for the Production of 5-Lipoxygenase Inhibitors." | IC50 1.715 uM | PMID:26416255 |
Open questions 1
shared-structure — This structure is reported by more than one MIBiG entry: BGC0001345, BGC0002324, BGC0002491, BGC0002492. Confirm they describe the same compound rather than an upstream cross-reference error.
Provenance
| Source concept | Source | Version |
|---|---|---|
| BGC0001345 | MIBIG | 5 |
| BGC0002324 | MIBIG | 3 |
| BGC0002491 | MIBIG | 3 |
| BGC0002492 | MIBIG | 3 |
This page is generated from data/natural_products/alkaloids/myxochelin-a.yaml, which is generated from the committed inventories. Neither is edited by hand.