neocarazostatin A
naturalproductmech:mibig-d56a84261d MINTED SEEDED
Structure
| Standard InChIKey | SALJSBDYICZFIP-UHFFFAOYSA-N |
|---|---|
| SMILES | CC1=C(C2=C(C3=C(N2)C=CC(=C3)CC=C(C)C)C(=C1OC)O)C(C(C)O)O |
| Stereochemistry | undefined stereocentres — the InChIKey does not distinguish this compound from its stereoisomers |
| Cross-references | pubchem:126263 |
Filing pathway
Alkaloids — computed by NPClassifier npclassifier.gnps2.org@2026-09-07, which is why it is pinned rather than recomputed. The gene cluster's asserted class is other, from MIBiG.
Producer organisms 1
A claim that this taxon makes the compound. The basis says what the evidence addressed — a knockout and a database assertion are not the same claim.
| Taxon | Basis | Cluster | Evidence |
|---|---|---|---|
| Streptomyces sp. MA37 NCBITaxon:1400207 |
SOURCE_ASSERTION | mibig:BGC0001903 | PMID:26670080 |
Occurrences 0
None cited.
Biosynthetic gene clusters 1
| Accession | Host | Locus evidence | Genome |
|---|---|---|---|
| mibig:BGC0001903 | Streptomyces sp. MA37 NCBITaxon:1400207 |
CLUSTER_UNSTATED | genbank:KP657980.1 |
A locus claim and a taxon claim are different questions. Heterologous expression settles the first and leaves the second where the isolation report left it.
Bioactivities 9
| Assay | Result | Reference |
|---|---|---|
| OTUD3 deubiquitinase inhibition: Dose-response Confirmation | ACTIVE | pubchem.aid:1645868 |
| USP17 deubiquitinase inhibition: Dose-response Confirmation | ACTIVE | pubchem.aid:1645864 |
| USP17 deubiquitinase inhibition: Primary qHTS | ACTIVE | pubchem.aid:1645855 |
| USP28 deubiquitinase inhibition: Dose-response Confirmation | ACTIVE | pubchem.aid:1645866 |
| USP28 deubiquitinase inhibition: Primary qHTS | ACTIVE | pubchem.aid:1645857 |
| USP30 deubiquitinase inhibition: Dose-response Confirmation | ACTIVE | pubchem.aid:1645865 |
| USP30 deubiquitinase inhibition: Primary qHTS | ACTIVE | pubchem.aid:1645860 |
| USP8 deubiquitinase inhibition: Dose-response Confirmation | ACTIVE | pubchem.aid:1645862 |
| USP8 deubiquitinase inhibition: Primary qHTS | ACTIVE | pubchem.aid:1645853 |
Provenance
| Source concept | Source | Version |
|---|---|---|
| BGC0001903 | MIBIG | 3 |
This page is generated from data/natural_products/alkaloids/neocarazostatin-a.yaml, which is generated from the committed inventories. Neither is edited by hand.