nybomycin
naturalproductmech:mibig-a67b9d4402 MINTED SEEDED antibacterial
Structure
| Standard InChIKey | HKMUGCUFXWTNSP-UHFFFAOYSA-N |
|---|---|
| SMILES | CC1=CC(=O)N2COC3=C2C1=CC4=C3N(C(=O)C=C4CO)C |
| Stereochemistry | fully defined |
| Cross-references | pubchem:169159 |
Filing pathway
Alkaloids — computed by NPClassifier npclassifier.gnps2.org@2026-09-07, which is why it is pinned rather than recomputed. The gene cluster's asserted class is other, from MIBiG.
Producer organisms 1
A claim that this taxon makes the compound. The basis says what the evidence addressed — a knockout and a database assertion are not the same claim.
| Taxon | Basis | Cluster | Evidence |
|---|---|---|---|
| Streptomyces albus subsp. chlorinus NCBITaxon:337066 |
SOURCE_ASSERTION | mibig:BGC0001965 | PMID:30400361 |
Occurrences 0
None cited.
Biosynthetic gene clusters 1
| Accession | Host | Locus evidence | Genome |
|---|---|---|---|
| mibig:BGC0001965 | Streptomyces albus subsp. chlorinus NCBITaxon:337066 |
CLUSTER_UNSTATED | genbank:MH924838.1 |
A locus claim and a taxon claim are different questions. Heterologous expression settles the first and leaves the second where the isolation report left it.
Bioactivities 6
| Assay | Result | Reference |
|---|---|---|
| USP10 deubiquitinase inhibition: Dose-response Confirmation | ACTIVE | pubchem.aid:1645863 |
| USP17 deubiquitinase inhibition: Dose-response Confirmation | ACTIVE | pubchem.aid:1645864 |
| USP17 deubiquitinase inhibition: Primary qHTS | ACTIVE | pubchem.aid:1645855 |
| USP28 deubiquitinase inhibition: Dose-response Confirmation | ACTIVE | pubchem.aid:1645866 |
| USP8 deubiquitinase inhibition: Dose-response Confirmation | ACTIVE | pubchem.aid:1645862 |
| USP8 deubiquitinase inhibition: Primary qHTS | ACTIVE | pubchem.aid:1645853 |
Elsewhere in the fleet
- AntibioticMech — antibioticmech:aro-6fbc93a42c (same structure, same inchikey)
Provenance
| Source concept | Source | Version |
|---|---|---|
| BGC0001965 | MIBIG | 4 |
This page is generated from data/natural_products/alkaloids/nybomycin.yaml, which is generated from the committed inventories. Neither is edited by hand.