ochrindole A
CHEBI:167043 EXACT SEEDED antibacterial
What these status tags mean
Curation status describes a workflow state. SEEDED means the record entered through the source-seeding workflow; it does not imply that no later curation occurred. PROPOSED marks an addition awaiting review; REVIEWED records curator sign-off on identity, structure, filing class and producer claims; DEPRECATED retains a superseded or out-of-scope record. These are workflow decisions, not independently verified human review. Agent-assisted contributions may appear in the record history.
Grounding describes the identifier mapping: EXACT uses an ontology identity asserted by the source; MINTED keeps a local identifier when no defensible ontology identity is available; REVIEW_NEEDED flags an exact structure whose ontology identity needs adjudication. The grounding note retains any unresolved alternatives. These tags do not establish the strength of producer or activity evidence.
A bisindole alkaloid that is phenol bearing a 3,3-dimethylallyl group at position 4, two methoxy groups at positions 3 and 6, and two indol-3-yl groups at positions 2 and 5. It is a natural product isolated from the sclerotia of Aspergillus orbraceus, with moderate activity against some insects, as well as Gram-positive bacteria.
Structure
| Standard InChIKey | YVQFFNCNPFQQKW-UHFFFAOYSA-N |
|---|---|
| SMILES | COC1=C(O)C(C2=CNC3=CC=CC=C23)=C(OC)C(CC=C(C)C)=C1C1=CNC2=C1C=CC=C2 |
| Stereochemistry | fully defined |
| Cross-references | npatlas:NPA01610 |
Filing pathway
Alkaloids — computed by NPClassifier npclassifier.gnps2.org@2026-09-07, which is why it is pinned rather than recomputed. The gene cluster's asserted class is other, from MIBiG.
Producer organisms 1
A claim that this taxon makes the compound. The basis says what the evidence addressed — a knockout and a database assertion are not the same claim.
| Taxon | Basis | Cluster | Evidence |
|---|---|---|---|
| Aspergillus steynii IBT 23096 NCBITaxon:1392250 |
SOURCE_ASSERTION | mibig:BGC0001712 | DOI:10.3390/molecules27196759 |
Occurrences 3
Somebody found the compound in this organism and cited it. That is not a claim that the organism makes it, and nothing here promotes one to the other.
| Taxon | Source | Reference |
|---|---|---|
| Aspergillus steynii NCBITaxon:306088 |
LOTUS | DOI:10.1073/PNAS.1715954115 |
| Aspergillus ochraceus NCBITaxon:40380 |
LOTUS | DOI:10.1021/NP50107A011 |
| Aspergillus ochraceus NCBITaxon:40380 |
CHEBI | PMID:8064296 |
Biosynthetic gene clusters 1
| Accession | Host | Locus evidence | Genome |
|---|---|---|---|
| mibig:BGC0001712 | Aspergillus steynii IBT 23096 NCBITaxon:1392250 |
CLUSTER_UNSTATED | genbank:MSFO01000007.1 |
A locus claim and a taxon claim are different questions. Heterologous expression settles the first and leaves the second where the isolation report left it.
Mechanism & Biosynthesis Overview
Elsewhere in the fleet
- AntibioticMech — CHEBI:167043 (same structure, same inchikey)
Explore across X-Mech
Provenance
| Source concept | Source | Version |
|---|---|---|
| BGC0001712 | MIBIG | 3 |
| CHEBI:167043 | CHEBI | 3-star |
This page is generated from data/natural_products/alkaloids/ochrindole-a.yaml, which is generated from the committed inventories. Neither is edited by hand.