odilorhabdin NOSO-95C

naturalproductmech:mibig-8b0b12acd8 MINTED SEEDED

Grounding review: No 3-star ChEBI entry shares this structure, so the record keeps a content-hashed identifier.

What these status tags mean

Curation status describes a workflow state. SEEDED means the record entered through the source-seeding workflow; it does not imply that no later curation occurred. PROPOSED marks an addition awaiting review; REVIEWED records curator sign-off on identity, structure, filing class and producer claims; DEPRECATED retains a superseded or out-of-scope record. These are workflow decisions, not independently verified human review. Agent-assisted contributions may appear in the record history.

Grounding describes the identifier mapping: EXACT uses an ontology identity asserted by the source; MINTED keeps a local identifier when no defensible ontology identity is available; REVIEW_NEEDED flags an exact structure whose ontology identity needs adjudication. The grounding note retains any unresolved alternatives. These tags do not establish the strength of producer or activity evidence.

Structure

Standard InChIKey	VFODIGMPMDOVDF-SLXJRBCYSA-N
SMILES	C1C[C@H](N(C1)C(=O)[C@@H](CCCN)NC(=O)CNC(=O)[C@H]([C@H](CN)O)NC(=O)[C@H]([C@H](CN)O)NC(=O)[C@H](CCCCN)N)C(=O)N[C@@H](CC2=CN=CN2)C(=O)N[C@@H](CCCCN)C(=O)N/C(=C\CCN=C(N)N)/C(=O)N[C@@H](CCCCN)C(=O)NCCCCN
Stereochemistry	fully defined
Cross-references	pubchem:132031638

Filing pathway

Alkaloids — computed by NPClassifier npclassifier.gnps2.org@2026-09-07, which is why it is pinned rather than recomputed. The gene cluster's asserted class is nrps, from MIBiG.

Producer organisms 1

A claim that this taxon makes the compound. The basis says what the evidence addressed — a knockout and a database assertion are not the same claim.

Taxon	Basis	Cluster	Evidence
Xenorhabdus nematophila AN6/1 NCBITaxon:1437823	SOURCE_ASSERTION	mibig:BGC0001716	PMID:29625040

Occurrences 1

Somebody found the compound in this organism and cited it. That is not a claim that the organism makes it, and nothing here promotes one to the other.

Taxon	Source	Reference
Xenorhabdus nematophila NCBITaxon:628	LOTUS	DOI:10.1016/J.MOLCEL.2018.03.001

Biosynthetic gene clusters 1

Accession	Host	Locus evidence	Genome
mibig:BGC0001716	Xenorhabdus nematophila AN6/1 NCBITaxon:1437823	CLUSTER_UNSTATED	genbank:LN681227.1

A locus claim and a taxon claim are different questions. Heterologous expression settles the first and leaves the second where the isolation report left it.

Mechanism & Biosynthesis Overview

Bioactivities 2

Entries preserve source qualifiers, targets and evidence. Repeated assay names or values are not independent replications; inspect source detail for differences.

Assay	Result	Target enzyme	Source detail
Calcium Channels Interaction from US Patent US10626144: "Peptide derivatives and uses thereof"	IC50 0.009 uM; ACTIVE	UniProtKB:Q00975	pubchem.aid:1919625 assay Calcium Channels Interaction from US Patent US10626144: "Peptide derivatives and uses thereof" evidence reference pubchem.aid:1919625 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 1919625, deposited by BindingDB; assay type Confirmatory. call ACTIVE measurement type IC50 value 0.009 units uM target enzyme UniProtKB:Q00975
Calcium Channels Interaction from US Patent US10626144: "Peptide derivatives and uses thereof"	IC50 0.03 uM; ACTIVE	UniProtKB:Q00975	pubchem.aid:1919625 assay Calcium Channels Interaction from US Patent US10626144: "Peptide derivatives and uses thereof" evidence reference pubchem.aid:1919625 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 1919625, deposited by BindingDB; assay type Confirmatory. call ACTIVE measurement type IC50 value 0.03 units uM target enzyme UniProtKB:Q00975

Explore across X-Mech

AntibioticMech (odilorhabdin NOSO-95C) ↗ MediaIngredientMech (naturalproductmech:mibig-8b0b12acd8) ↗ TaxonMech: Xenorhabdus nematophila AN6/1 (NCBITaxon:1437823) ↗ PathwayMech (mibig:BGC0001716) ↗

Provenance

Source concept	Source	Version
BGC0001716	MIBIG	4

This page is generated from data/natural_products/alkaloids/odilorhabdin-noso-95c.yaml, which is generated from the committed inventories. Neither is edited by hand.