pyrrolomycin A
CHEBI:156550 EXACT SEEDED antibacterial
What these status tags mean
Curation status describes a workflow state. SEEDED means the record entered through the source-seeding workflow; it does not imply that no later curation occurred. PROPOSED marks an addition awaiting review; REVIEWED records curator sign-off on identity, structure, filing class and producer claims; DEPRECATED retains a superseded or out-of-scope record. These are workflow decisions, not independently verified human review. Agent-assisted contributions may appear in the record history.
Grounding describes the identifier mapping: EXACT uses an ontology identity asserted by the source; MINTED keeps a local identifier when no defensible ontology identity is available; REVIEW_NEEDED flags an exact structure whose ontology identity needs adjudication. The grounding note retains any unresolved alternatives. These tags do not establish the strength of producer or activity evidence.
A member of the class of pyrroles that is 1H-pyrrole which is substituted by chloro groups at positions 2 and 3 and by a nitro group position 4. It is the simplest member of the pyrrolomycins, a family of natural products found in several species of the Streptomyces genus. The compound is active against Gram-positive and Gram-negative bacteria and some genera of fungi.
Structure
| Standard InChIKey | CDHAYBUDIPNGGJ-UHFFFAOYSA-N |
|---|---|
| SMILES | C1=C(C(=C(N1)Cl)Cl)[N+](=O)[O-] |
| Stereochemistry | fully defined |
| Cross-references | pubchem:133275 |
Filing pathway
Alkaloids — computed by NPClassifier npclassifier.gnps2.org@2026-09-07, which is why it is pinned rather than recomputed. The gene cluster's asserted class is pks, from MIBiG.
Producer organisms 3
A claim that this taxon makes the compound. The basis says what the evidence addressed — a knockout and a database assertion are not the same claim.
| Taxon | Basis | Cluster | Evidence |
|---|---|---|---|
| Streptomyces vitaminophilus NCBITaxon:76728 |
SOURCE_ASSERTION | mibig:BGC0000130 | PMID:17158935 |
| Streptomyces sp. UC 11065 NCBITaxon:428401 |
SOURCE_ASSERTION | mibig:BGC0000131 | PMID:17158935 |
| Streptomyces sp. UC 11065 NCBITaxon:428401 |
SOURCE_ASSERTION | mibig:BGC0000132 | PMID:17158935 |
Occurrences 4
Somebody found the compound in this organism and cited it. That is not a claim that the organism makes it, and nothing here promotes one to the other.
| Taxon | Source | Reference |
|---|---|---|
| Streptomyces NCBITaxon:1883 |
LOTUS | DOI:10.7164/ANTIBIOTICS.34.1363 |
| Streptomyces vitaminophilus NCBITaxon:76728 |
LOTUS | DOI:10.1128/GENOMEA.01582-15 |
| Streptomyces vitaminophilus NCBITaxon:76728 |
LOTUS | DOI:10.7164/ANTIBIOTICS.36.1263 |
| Streptomyces vitaminophilus NCBITaxon:76728 |
CHEBI | PMID:17158935 |
Biosynthetic gene clusters 3
| Accession | Host | Locus evidence | Genome |
|---|---|---|---|
| mibig:BGC0000130 | Streptomyces vitaminophilus NCBITaxon:76728 |
CLUSTER_UNSTATED | genbank:EF140901.1 |
| mibig:BGC0000131 | Streptomyces sp. UC 11065 NCBITaxon:428401 |
CLUSTER_UNSTATED | genbank:EF140902.1 |
| mibig:BGC0000132 | Streptomyces sp. UC 11065 NCBITaxon:428401 |
CLUSTER_UNSTATED | genbank:EF140903.1 |
A locus claim and a taxon claim are different questions. Heterologous expression settles the first and leaves the second where the isolation report left it.
Mechanism & Biosynthesis Overview
Elsewhere in the fleet
- AntibioticMech — CHEBI:156550 (same structure, same inchikey)
Explore across X-Mech
Open questions 1
shared-structure — This structure is reported by more than one MIBiG entry: BGC0000130, BGC0000131, BGC0000132. Confirm they describe the same compound rather than an upstream cross-reference error.
Provenance
| Source concept | Source | Version |
|---|---|---|
| BGC0000130 | MIBIG | 5 |
| BGC0000131 | MIBIG | 5 |
| BGC0000132 | MIBIG | 3 |
| CHEBI:156550 | CHEBI | 3-star |
This page is generated from data/natural_products/alkaloids/pyrrolomycin-a.yaml, which is generated from the committed inventories. Neither is edited by hand.