saframycin A
naturalproductmech:mibig-5a2b2bf988 MINTED SEEDED
Structure
| Standard InChIKey | JNEGMBHBUAJRSX-SHUHUVMISA-N |
|---|---|
| SMILES | CC1=C(C(=O)C2=C(C1=O)C[C@H]3[C@H]4C5=C(C[C@H](N4C)[C@@H](N3[C@H]2CNC(=O)C(=O)C)C#N)C(=O)C(=C(C5=O)OC)C)OC |
| Stereochemistry | fully defined |
| Cross-references | pubchem:3086522, pubchem:100594 |
Filing pathway
Alkaloids — computed by NPClassifier npclassifier.gnps2.org@2026-09-07, which is why it is pinned rather than recomputed. The gene cluster's asserted class is nrps, from MIBiG.
Producer organisms 1
A claim that this taxon makes the compound. The basis says what the evidence addressed — a knockout and a database assertion are not the same claim.
| Taxon | Basis | Cluster | Evidence |
|---|---|---|---|
| Streptomyces lavendulae NCBITaxon:1914 |
SOURCE_ASSERTION | mibig:BGC0000422 | PMID:17981978 |
Occurrences 4
Somebody found the compound in this organism and cited it. That is not a claim that the organism makes it, and nothing here promotes one to the other.
| Taxon | Source | Reference |
|---|---|---|
| Streptomyces lavendulae NCBITaxon:1914 |
LOTUS | DOI:10.1128/AAC.28.1.5 |
| Streptomyces lavendulae NCBITaxon:1914 |
LOTUS | DOI:10.1128/JB.00826-07 |
| Streptomyces lavendulae NCBITaxon:1914 |
LOTUS | DOI:10.7164/ANTIBIOTICS.30.1015 |
| Streptomyces lavendulae NCBITaxon:1914 |
LOTUS | DOI:10.7164/ANTIBIOTICS.41.734 |
Biosynthetic gene clusters 1
| Accession | Host | Locus evidence | Genome |
|---|---|---|---|
| mibig:BGC0000422 | Streptomyces lavendulae NCBITaxon:1914 |
CLUSTER_UNSTATED | genbank:DQ838002.1 |
A locus claim and a taxon claim are different questions. Heterologous expression settles the first and leaves the second where the isolation report left it.
Provenance
| Source concept | Source | Version |
|---|---|---|
| BGC0000422 | MIBIG | 5 |
This page is generated from data/natural_products/alkaloids/saframycin-a.yaml, which is generated from the committed inventories. Neither is edited by hand.