saxitoxin

CHEBI:34970 EXACT SEEDED

What these status tags mean

Curation status describes a workflow state. SEEDED means the record entered through the source-seeding workflow; it does not imply that no later curation occurred. PROPOSED marks an addition awaiting review; REVIEWED records curator sign-off on identity, structure, filing class and producer claims; DEPRECATED retains a superseded or out-of-scope record. These are workflow decisions, not independently verified human review. Agent-assisted contributions may appear in the record history.

Grounding describes the identifier mapping: EXACT uses an ontology identity asserted by the source; MINTED keeps a local identifier when no defensible ontology identity is available; REVIEW_NEEDED flags an exact structure whose ontology identity needs adjudication. The grounding note retains any unresolved alternatives. These tags do not establish the strength of producer or activity evidence.

An alkaloid isolated from the marine dinoflagellates and cyanobacteria that causes paralytic shellfish poisoning.

Structure

Standard InChIKey	RPQXVSUAYFXFJA-HGRQIUPRSA-N
SMILES	C1CN2C(=N[C@H]([C@H]3[C@]2(C1(O)O)N=C(N3)N)COC(=O)N)N
Stereochemistry	fully defined
Cross-references	pubchem:37165, chembl:CHEMBL501134

Filing pathway

Alkaloids — computed by NPClassifier npclassifier.gnps2.org@2026-09-07, which is why it is pinned rather than recomputed. The gene cluster's asserted class is other, from MIBiG.

Producer organisms 1

A claim that this taxon makes the compound. The basis says what the evidence addressed — a knockout and a database assertion are not the same claim.

Taxon	Basis	Cluster	Evidence
Cylindrospermopsis raciborskii T3 NCBITaxon:398006	SOURCE_ASSERTION	mibig:BGC0000188	PMID:18487408

Occurrences 25

Somebody found the compound in this organism and cited it. That is not a claim that the organism makes it, and nothing here promotes one to the other.

Taxon	Source	Reference
Saxidomus nuttalli NCBITaxon:1129274	LOTUS	DOI:10.1016/0041-0101(85)90159-X
Saxidomus nuttalli NCBITaxon:1129274	LOTUS	DOI:10.1016/0198-0254(85)94069-5
Anabaena NCBITaxon:1163	LOTUS	DOI:10.1016/0041-0101(86)90120-0
Anabaena NCBITaxon:1163	LOTUS	DOI:10.1021/JA00838A045
Aphanizomenon NCBITaxon:1175	LOTUS	DOI:10.1021/JA00838A045
Aphanizomenon flos-aquae NCBITaxon:1176	LOTUS	DOI:10.1016/0041-0101(86)90120-0
Aphanizomenon flos-aquae NCBITaxon:1176	LOTUS	DOI:10.1016/S0040-4039(00)80500-6
Lingulodinium polyedra NCBITaxon:160621	LOTUS	DOI:10.1016/0041-0101(90)90150-6
Takifugu radiatus NCBITaxon:176186	LOTUS	DOI:10.1016/0041-0101(84)90082-5
Takifugu poecilonotus NCBITaxon:176188	LOTUS	DOI:10.1016/0041-0101(84)90082-5
Takifugu vermicularis NCBITaxon:177060	LOTUS	DOI:10.1016/0041-0101(84)90082-5
Gonyaulax NCBITaxon:2912	LOTUS	DOI:10.1351/PAC198254101973
Gonyaulax catenella NCBITaxon:2925	LOTUS	DOI:10.1016/0041-0101(85)90031-5
Gonyaulax catenella NCBITaxon:2925	LOTUS	DOI:10.1016/0041-0101(90)90132-Q
Gonyaulax catenella NCBITaxon:2925	LOTUS	DOI:10.1021/BI00868A011
Gonyaulax tamarensis NCBITaxon:2926	LOTUS	DOI:10.1016/0041-0101(90)90132-Q
Gonyaulax tamarensis NCBITaxon:2926	LOTUS	DOI:10.1248/JHS1956.30.5_328
Saxidomus gigantea NCBITaxon:410349	LOTUS	DOI:10.1021/JF60198A016
Planktothrix NCBITaxon:54304	LOTUS	DOI:10.1016/0041-0101(86)90120-0
Planktothrix NCBITaxon:54304	LOTUS	DOI:10.1021/JA00838A045
Carcinoscorpius rotundicauda NCBITaxon:6848	LOTUS	DOI:10.1016/0041-0101(88)90064-5
Carcinoscorpius rotundicauda NCBITaxon:6848	LOTUS	DOI:10.2331/SUISAN.53.261
Pyrodinium bahamense NCBITaxon:73915	LOTUS	DOI:10.1016/0041-0101(84)90082-5
Cylindrospermopsis NCBITaxon:77021	LOTUS	DOI:10.1016/0041-0101(86)90120-0
Cylindrospermopsis NCBITaxon:77021	LOTUS	DOI:10.1021/JA00838A045

Biosynthetic gene clusters 1

Accession	Host	Locus evidence	Genome
mibig:BGC0000188	Cylindrospermopsis raciborskii T3 NCBITaxon:398006	CLUSTER_UNSTATED	genbank:DQ787200.1

A locus claim and a taxon claim are different questions. Heterologous expression settles the first and leaves the second where the isolation report left it.

Mechanism & Biosynthesis Overview

Explore across X-Mech

AntibioticMech (saxitoxin) ↗ MediaIngredientMech (CHEBI:34970) ↗ TaxonMech: Cylindrospermopsis raciborskii T3 (NCBITaxon:398006) ↗ PathwayMech (mibig:BGC0000188) ↗

Provenance

Source concept	Source	Version
BGC0000188	MIBIG	5
CHEBI:34970	CHEBI	3-star

This page is generated from data/natural_products/alkaloids/saxitoxin.yaml, which is generated from the committed inventories. Neither is edited by hand.