streptazone E
CHEBI:156388 EXACT SEEDED
What these status tags mean
Curation status describes a workflow state. SEEDED means the record entered through the source-seeding workflow; it does not imply that no later curation occurred. PROPOSED marks an addition awaiting review; REVIEWED records curator sign-off on identity, structure, filing class and producer claims; DEPRECATED retains a superseded or out-of-scope record. These are workflow decisions, not independently verified human review. Agent-assisted contributions may appear in the record history.
Grounding describes the identifier mapping: EXACT uses an ontology identity asserted by the source; MINTED keeps a local identifier when no defensible ontology identity is available; REVIEW_NEEDED flags an exact structure whose ontology identity needs adjudication. The grounding note retains any unresolved alternatives. These tags do not establish the strength of producer or activity evidence.
A member of the class of cyclopentapyridines that is 2,3,4,5-tetrahydro-1H-cyclopenta[b]pyridine substituted by an oxo group at position 4 and by a (2E)-but-2-en-1-ylidene group at position 5. It is a polyketide natural product found in Streptomyces sp.
Structure
| Standard InChIKey | HKLWUXDZILHGOB-DSXPNFDZSA-N |
|---|---|
| SMILES | C\C=C\C=C1/C=CC2=C1C(=O)CCN2 |
| Stereochemistry | fully defined |
| Cross-references | npatlas:NPA05197 |
Filing pathway
Alkaloids — computed by NPClassifier npclassifier.gnps2.org@2026-09-07, which is why it is pinned rather than recomputed. The gene cluster's asserted class is pks, from MIBiG.
Producer organisms 1
A claim that this taxon makes the compound. The basis says what the evidence addressed — a knockout and a database assertion are not the same claim.
| Taxon | Basis | Cluster | Evidence |
|---|---|---|---|
| Streptomyces sp. MSC090213JE08 NCBITaxon:1670457 |
SOURCE_ASSERTION | mibig:BGC0001296 | PMID:26403163 |
Occurrences 4
Somebody found the compound in this organism and cited it. That is not a claim that the organism makes it, and nothing here promotes one to the other.
| Taxon | Source | Reference |
|---|---|---|
| Streptomyces sp. NEAU-Z4 NCBITaxon:1218706 |
CHEBI | PMID:23421585 |
| Streptomyces NCBITaxon:1883 |
LOTUS | DOI:10.1002/CBIC.201500317 |
| Streptomyces NCBITaxon:1883 |
LOTUS | DOI:10.1080/10286020.2012.761209 |
| Streptomyces sp. MSC090213JE08 NCBITaxon:1670457 |
CHEBI | PMID:26403163 |
Biosynthetic gene clusters 1
| Accession | Host | Locus evidence | Genome |
|---|---|---|---|
| mibig:BGC0001296 | Streptomyces sp. MSC090213JE08 NCBITaxon:1670457 |
CLUSTER_UNSTATED | genbank:LC061217.1 |
A locus claim and a taxon claim are different questions. Heterologous expression settles the first and leaves the second where the isolation report left it.
Mechanism & Biosynthesis Overview
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Provenance
| Source concept | Source | Version |
|---|---|---|
| BGC0001296 | MIBIG | 3 |
| CHEBI:156388 | CHEBI | 3-star |
This page is generated from data/natural_products/alkaloids/streptazone-e.yaml, which is generated from the committed inventories. Neither is edited by hand.