streptonigrin
CHEBI:9287 EXACT SEEDED antimicrobial unspecified
Complex cytotoxic antibiotic obtained from Streptomyces flocculus or S. rufochronmogenus. It is used in advanced carcinoma and causes leukopenia.
Structure
| Standard InChIKey | PVYJZLYGTZKPJE-UHFFFAOYSA-N |
|---|---|
| SMILES | COC1=CC=C(C(O)=C1OC)C1=C(N)C(=NC(C(O)=O)=C1C)C1=NC2=C(C=C1)C(=O)C(OC)=C(N)C2=O |
| Stereochemistry | fully defined |
| Cross-references | npatlas:NPA02378 |
Filing pathway
Alkaloids — computed by NPClassifier npclassifier.gnps2.org@2026-09-07, which is why it is pinned rather than recomputed. The gene cluster's asserted class is other, from MIBiG.
Producer organisms 1
A claim that this taxon makes the compound. The basis says what the evidence addressed — a knockout and a database assertion are not the same claim.
| Taxon | Basis | Cluster | Evidence |
|---|---|---|---|
| Streptomyces flocculus NCBITaxon:1888 |
SOURCE_ASSERTION | mibig:BGC0001783 | PMID:23301954 |
Occurrences 7
Somebody found the compound in this organism and cited it. That is not a claim that the organism makes it, and nothing here promotes one to the other.
| Taxon | Source | Reference |
|---|---|---|
| Micromonospora NCBITaxon:1873 |
LOTUS | DOI:10.1021/NP0104572 |
| Streptomyces NCBITaxon:1883 |
LOTUS | DOI:10.7164/ANTIBIOTICS.38.1429 |
| Streptomyces NCBITaxon:1883 |
LOTUS | DOI:10.7164/ANTIBIOTICS.38.516 |
| Streptomyces albus NCBITaxon:1888 |
LOTUS | DOI:10.1016/S0040-4039(01)85595-7 |
| Streptomyces albus NCBITaxon:1888 |
LOTUS | DOI:10.1021/JA00236A071 |
| Streptomyces albus NCBITaxon:1888 |
LOTUS | DOI:10.1021/JA00899A051 |
| Streptomyces albus NCBITaxon:1888 |
LOTUS | DOI:10.1042/BJ2200309 |
Biosynthetic gene clusters 1
| Accession | Host | Locus evidence | Genome |
|---|---|---|---|
| mibig:BGC0001783 | Streptomyces flocculus NCBITaxon:1888 |
CLUSTER_UNSTATED | genbank:JQ414024.1 |
A locus claim and a taxon claim are different questions. Heterologous expression settles the first and leaves the second where the isolation report left it.
Elsewhere in the fleet
- AntibioticMech — CHEBI:9287 (same structure, same inchikey)
Provenance
| Source concept | Source | Version |
|---|---|---|
| BGC0001783 | MIBIG | 5 |
| CHEBI:9287 | CHEBI | 3-star |
This page is generated from data/natural_products/alkaloids/streptonigrin.yaml, which is generated from the committed inventories. Neither is edited by hand.