tilivalline
CHEBI:156292 EXACT SEEDED
A pyrrolobenzodiazepine that is (11aS)-2,3,5,10,11,11a-hexahydro-1H-pyrrolo[2,1-c][1,4]benzodiazepine substituted by an oxo group at position 5, by a hydroxy group at position 9, and by a 1H-indol-3-yl group at position 11S. It is a natural product discovered in Klebsiella oxytoca which is the causative toxin in antibiotic associated hemorrhagic colitis. It exhibits a microtubule-stabilizing activity that leads to mitotic arrest in the host cells.
Structure
| Standard InChIKey | AJZNARCWDDMOPL-WMZOPIPTSA-N |
|---|---|
| SMILES | C1C[C@H]2[C@@H](NC3=C(C=CC=C3O)C(=O)N2C1)C4=CNC5=CC=CC=C54 |
| Stereochemistry | fully defined |
| Cross-references | pubchem:128363 |
Filing pathway
Alkaloids — computed by NPClassifier npclassifier.gnps2.org@2026-09-07, which is why it is pinned rather than recomputed. The gene cluster's asserted class is nrps, from MIBiG.
Producer organisms 1
A claim that this taxon makes the compound. The basis says what the evidence addressed — a knockout and a database assertion are not the same claim.
| Taxon | Basis | Cluster | Evidence |
|---|---|---|---|
| Klebsiella oxytoca NCBITaxon:571 |
BGC_CORRELATED | mibig:BGC0000446 | PMID:25157164 |
Occurrences 4
Somebody found the compound in this organism and cited it. That is not a claim that the organism makes it, and nothing here promotes one to the other.
| Taxon | Source | Reference |
|---|---|---|
| Xenorhabdus eapokensis NCBITaxon:1873482 |
CHEBI | PMID:29596433 |
| Klebsiella pneumoniae NCBITaxon:573 |
LOTUS | DOI:10.1016/0040-4020(82)85058-8 |
| Klebsiella pneumoniae NCBITaxon:573 |
CHEBI | PMID:11672297 |
| Klebsiella oxytoca NCBITaxon:571 |
CHEBI | PMID:29389112 |
Biosynthetic gene clusters 1
| Accession | Host | Locus evidence | Genome |
|---|---|---|---|
| mibig:BGC0000446 | Klebsiella oxytoca NCBITaxon:571 |
CLUSTER_CORRELATED | genbank:HG425356.1 |
A locus claim and a taxon claim are different questions. Heterologous expression settles the first and leaves the second where the isolation report left it.
Provenance
| Source concept | Source | Version |
|---|---|---|
| BGC0000446 | MIBIG | 5 |
| CHEBI:156292 | CHEBI | 3-star |
This page is generated from data/natural_products/alkaloids/tilivalline.yaml, which is generated from the committed inventories. Neither is edited by hand.