amychelin A
naturalproductmech:mibig-ced0ce32ac MINTED SEEDED
What these status tags mean
Curation status describes a workflow state. SEEDED means the record entered through the source-seeding workflow; it does not imply that no later curation occurred. PROPOSED marks an addition awaiting review; REVIEWED records curator sign-off on identity, structure, filing class and producer claims; DEPRECATED retains a superseded or out-of-scope record. These are workflow decisions, not independently verified human review. Agent-assisted contributions may appear in the record history.
Grounding describes the identifier mapping: EXACT uses an ontology identity asserted by the source; MINTED keeps a local identifier when no defensible ontology identity is available; REVIEW_NEEDED flags an exact structure whose ontology identity needs adjudication. The grounding note retains any unresolved alternatives. These tags do not establish the strength of producer or activity evidence.
Structure
| Standard InChIKey | YMYRNIMWOZETPY-OVQJPPBNSA-N |
|---|---|
| SMILES | OC[C@@H](NC(=O)[C@H](CO)NC(=O)[C@H]1COC(=N1)C1=CC=CC=C1O)C(=O)N[C@@H](CO)C(=O)N[C@H](CCCN(O)C=O)C(=O)N[C@@H]1CCCN(O)C1=O |
| Stereochemistry | fully defined |
| Cross-references | npatlas:NPA011646, pubchem:24205476 |
Filing pathway
Amino acids and peptides — computed by NPClassifier npclassifier.gnps2.org@2026-09-07, which is why it is pinned rather than recomputed. The gene cluster's asserted class is nrps, from MIBiG.
Producer organisms 2
A claim that this taxon makes the compound. The basis says what the evidence addressed — a knockout and a database assertion are not the same claim.
| Taxon | Basis | Cluster | Evidence |
|---|---|---|---|
| Streptomyces sp. AA4 NCBITaxon:591158 |
SOURCE_ASSERTION | mibig:BGC0000300 | PMID:21699219 |
| Amycolatopsis methanolica NCBITaxon:1814 |
SOURCE_ASSERTION | mibig:BGC0002544 | PMID:33186541 |
Occurrences 2
Somebody found the compound in this organism and cited it. That is not a claim that the organism makes it, and nothing here promotes one to the other.
| Taxon | Source | Reference |
|---|---|---|
| Amycolatopsis NCBITaxon:1813 |
LOTUS | DOI:10.1021/JA203577E |
| Streptomyces NCBITaxon:1883 |
LOTUS | DOI:10.1021/JA203577E |
Biosynthetic gene clusters 2
| Accession | Host | Locus evidence | Genome |
|---|---|---|---|
| mibig:BGC0000300 | Streptomyces sp. AA4 NCBITaxon:591158 |
CLUSTER_UNSTATED | genbank:GG657746.1 |
| mibig:BGC0002544 | Amycolatopsis methanolica NCBITaxon:1814 |
CLUSTER_UNSTATED | genbank:MT001874.1 |
A locus claim and a taxon claim are different questions. Heterologous expression settles the first and leaves the second where the isolation report left it.
Mechanism & Biosynthesis Overview
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Open questions 1
shared-structure — This structure is reported by more than one MIBiG entry: BGC0000300, BGC0002544. Confirm they describe the same compound rather than an upstream cross-reference error.
Provenance
| Source concept | Source | Version |
|---|---|---|
| BGC0000300 | MIBIG | 5 |
| BGC0002544 | MIBIG | 3 |
This page is generated from data/natural_products/amino_acids_and_peptides/amychelin-a.yaml, which is generated from the committed inventories. Neither is edited by hand.