aztreonam
CHEBI:161680 EXACT SEEDED antibacterial
What these status tags mean
Curation status describes a workflow state. SEEDED means the record entered through the source-seeding workflow; it does not imply that no later curation occurred. PROPOSED marks an addition awaiting review; REVIEWED records curator sign-off on identity, structure, filing class and producer claims; DEPRECATED retains a superseded or out-of-scope record. These are workflow decisions, not independently verified human review. Agent-assisted contributions may appear in the record history.
Grounding describes the identifier mapping: EXACT uses an ontology identity asserted by the source; MINTED keeps a local identifier when no defensible ontology identity is available; REVIEW_NEEDED flags an exact structure whose ontology identity needs adjudication. The grounding note retains any unresolved alternatives. These tags do not establish the strength of producer or activity evidence.
A synthetic monocyclic β-lactam antibiotic (monobactam), used primarily to treat infections caused by Gram-negative bacteria. It inhibits mucopeptide synthesis in the bacterial cell wall, thereby blocking peptidoglycan crosslinking.
Structure
| Standard InChIKey | WZPBZJONDBGPKJ-VEHQQRBSSA-N |
|---|---|
| SMILES | C[C@H]1[C@@H](C(=O)N1S(=O)(=O)[O-])NC(=O)/C(=N\OC(C)(C)C(=O)O)/C2=CSC(=N2)[NH3+] |
| Stereochemistry | fully defined |
Filing pathway
Amino acids and peptides — computed by NPClassifier npclassifier.gnps2.org@2026-09-07, which is why it is pinned rather than recomputed. The gene cluster's asserted class is nrps, from MIBiG.
Producer organisms 2
A claim that this taxon makes the compound. The basis says what the evidence addressed — a knockout and a database assertion are not the same claim.
| Taxon | Basis | Cluster | Evidence |
|---|---|---|---|
| Agrobacterium tumefaciens NCBITaxon:358 |
SOURCE_ASSERTION | mibig:BGC0001671 | url:https://macsphere.mcmaster.ca/bitstream/11375/22190/2/Walker_Chelsea_G_finalsubmission2017June_MasterofScience.pdf |
| [Flexibacter] sp. ATCC 35103 NCBITaxon:1937528 |
SOURCE_ASSERTION | mibig:BGC0001672 | url:https://macsphere.mcmaster.ca/bitstream/11375/22190/2/Walker_Chelsea_G_finalsubmission2017June_MasterofScience.pdf |
Occurrences 0
None cited.
Biosynthetic gene clusters 2
| Accession | Host | Locus evidence | Genome |
|---|---|---|---|
| mibig:BGC0001671 | Agrobacterium tumefaciens NCBITaxon:358 |
CLUSTER_UNSTATED | genbank:KY452017.1 |
| mibig:BGC0001672 | [Flexibacter] sp. ATCC 35103 NCBITaxon:1937528 |
CLUSTER_UNSTATED | genbank:KY502195.1 |
A locus claim and a taxon claim are different questions. Heterologous expression settles the first and leaves the second where the isolation report left it.
Mechanism & Biosynthesis Overview
Elsewhere in the fleet
- AntibioticMech — CHEBI:161680 (same structure, same inchikey)
Explore across X-Mech
Open questions 2
name-disagreement — ChEBI calls this structure 'aztreonam' and MIBiG calls it 'monobactam'. They share a Standard InChIKey, so if the names denote different compounds then one upstream record has the wrong structure. Check which.
shared-structure — This structure is reported by more than one MIBiG entry: BGC0001671, BGC0001672. Confirm they describe the same compound rather than an upstream cross-reference error.
Provenance
| Source concept | Source | Version |
|---|---|---|
| BGC0001671 | MIBIG | 3 |
| BGC0001672 | MIBIG | 3 |
| CHEBI:161680 | CHEBI | 3-star |
This page is generated from data/natural_products/amino_acids_and_peptides/aztreonam.yaml, which is generated from the committed inventories. Neither is edited by hand.