balhimycin

naturalproductmech:mibig-24dfb3f1a5 MINTED SEEDED

Grounding review: No 3-star ChEBI entry shares this structure, so the record keeps a content-hashed identifier.

What these status tags mean

Curation status describes a workflow state. SEEDED means the record entered through the source-seeding workflow; it does not imply that no later curation occurred. PROPOSED marks an addition awaiting review; REVIEWED records curator sign-off on identity, structure, filing class and producer claims; DEPRECATED retains a superseded or out-of-scope record. These are workflow decisions, not independently verified human review. Agent-assisted contributions may appear in the record history.

Grounding describes the identifier mapping: EXACT uses an ontology identity asserted by the source; MINTED keeps a local identifier when no defensible ontology identity is available; REVIEW_NEEDED flags an exact structure whose ontology identity needs adjudication. The grounding note retains any unresolved alternatives. These tags do not establish the strength of producer or activity evidence.

Structure

Standard InChIKey	WKNFBFHAYANQHF-HPBAPGONSA-N
SMILES	CNC(CC(C)C)C(=O)NC1C(O)C2=CC=C(OC3=C(OC4O[C@H](CO)C(O)[C@H](O)C4O)C4=CC(=C3)C(NC(=O)C(CC(N)=O)NC1=O)C(=O)NC1C3=CC(=C(O)C=C3)C3=C(O)C=C(O)C=C3C(NC(=O)C(NC1=O)C(OC1C[C@](C)(N)C(=O)C(C)O1)C1=CC=C(O4)C(Cl)=C1)C(O)=O)C(Cl)=C2
Stereochemistry	undefined stereocentres — the InChIKey does not distinguish this compound from its stereoisomers
Cross-references	pubchem:16131414, npatlas:NPA010597

Filing pathway

Amino acids and peptides — computed by NPClassifier npclassifier.gnps2.org@2026-09-07, which is why it is pinned rather than recomputed. The gene cluster's asserted class is saccharide, nrps, from MIBiG.

Producer organisms 1

A claim that this taxon makes the compound. The basis says what the evidence addressed — a knockout and a database assertion are not the same claim.

Taxon	Basis	Cluster	Evidence
Amycolatopsis balhimycina DSM 5908 NCBITaxon:1081091	BGC_CHARACTERIZED	mibig:BGC0000311	PMID:10390204

Occurrences 1

Somebody found the compound in this organism and cited it. That is not a claim that the organism makes it, and nothing here promotes one to the other.

Taxon	Source	Reference
Amycolatopsis balhimycina NCBITaxon:208443	LOTUS	DOI:10.1128/AAC.43.7.1565

Biosynthetic gene clusters 1

Accession	Host	Locus evidence	Genome
mibig:BGC0000311	Amycolatopsis balhimycina DSM 5908 NCBITaxon:1081091	CLUSTER_DEMONSTRATED	genbank:Y16952.3

A locus claim and a taxon claim are different questions. Heterologous expression settles the first and leaves the second where the isolation report left it.

Mechanism & Biosynthesis Overview

Causal graph — biosynthesis 4 nodes, 3 edges

Partial Amycolatopsis balhimycina balhimycin biosynthesis graph for OxyC-catalyzed cytochrome P450 oxidative cyclization.

Subject	Predicate	Object	Notes	Evidence
OxyC cyclization substrate	is cyclized by	OxyC cytochrome P450	MITE represents OxyC as installing a biaryl ether crosslink in a balhimycin-pathway intermediate; the exact submitted substrate and product structures are absent from local records.	DOI:10.1016/j.jbiotec.2006.04.009 DOI:10.1002/1521-3773(20011217)40:24<4688::AID-ANIE4688>3.0.CO;2-M https://mite.bioinformatics.nl/repository/MITE0000027 https://mibig.secondarymetabolites.org/repository/BGC0000311.6/BGC0000311.gbk https://www.uniprot.org/uniprotkb/O87675 https://www.ncbi.nlm.nih.gov/protein/CAA76549.1 reference DOI:10.1016/j.jbiotec.2006.04.009 evidence type PRIMARY_EXPERIMENT snippet The mutant NPoxyA produces mainly monocyclic, the mutant DeltaoxyB linear and the mutant DeltaoxyC bicyclic peptides notes Stegmann et al. constructed non-polar oxyA, oxyB and oxyC mutants in Amycolatopsis balhimycina, assayed their glycopeptide products by HPLC-ESI-MS, and established OxyC as the final enzyme in the OxyB-OxyA-OxyC oxidative ring-closing sequence. reference DOI:10.1002/1521-3773(20011217)40:24<4688::AID-ANIE4688>3.0.CO;2-M evidence type PRIMARY_EXPERIMENT notes Bischoff et al. analyzed balhimycin oxygenase mutants to establish the order of oxidative cyclization steps in vancomycin-type glycopeptide biosynthesis. reference https://mite.bioinformatics.nl/repository/MITE0000027 evidence type DATABASE_ASSERTION retrieved on 2026-10-02 notes MITE0000027 is active, assigns OxyC to a knock-out-supported cyclization that installs the second biaryl ether crosslink between hpg5 and dhpg7 of a balhimycin precursor, lists heme and Fe as cofactors, and links the enzyme to UniProtKB:O87675, GenPept CAA76549.1 and MIBiG BGC0000311. reference https://mibig.secondarymetabolites.org/repository/BGC0000311.6/BGC0000311.gbk evidence type DATABASE_ASSERTION snippet MITE0000027: Cyclization (89% identity) retrieved on 2026-10-02 notes MIBiG BGC0000311.6 places oxyC/CAA76549.1 inside the active Amycolatopsis balhimycina DSM 5908 balhimycin biosynthetic gene cluster as a P450 monooxygenase locus with a MITE0000027 cyclization annotation. reference https://www.uniprot.org/uniprotkb/O87675 evidence type DATABASE_ASSERTION snippet GN Name=oxyC retrieved on 2026-10-02 notes Current UniProtKB:O87675 resolves as a 406 aa Amycolatopsis balhimycina oxyC p450 monooxygenase entry and cross-references EMBL Y16952 protein CAA76549.1. reference https://www.ncbi.nlm.nih.gov/protein/CAA76549.1 evidence type DATABASE_ASSERTION snippet P450 monooxygenase retrieved on 2026-10-02 notes NCBI Protein CAA76549.1 is the Amycolatopsis balhimycina DSM 5908 oxyC P450 monooxygenase linked to UniProtKB/TrEMBL O87675.
heme	serves as cofactor for	OxyC cytochrome P450	MITE lists heme as OxyC's organic cofactor and UniProt annotates the O87675 entry with cytochrome P450, heme and iron features.	https://mite.bioinformatics.nl/repository/MITE0000027 https://www.uniprot.org/uniprotkb/O87675 reference https://mite.bioinformatics.nl/repository/MITE0000027 evidence type DATABASE_ASSERTION retrieved on 2026-10-02 notes MITE0000027 lists heme as OxyC's organic cofactor and Fe as its inorganic cofactor. reference https://www.uniprot.org/uniprotkb/O87675 evidence type DATABASE_ASSERTION retrieved on 2026-10-02 notes UniProtKB:O87675 carries heme and iron ligand keywords and cytochrome P450 domain cross-references.
OxyC cytochrome P450	forms	OxyC-cyclized balhimycin intermediate	The MITE product corresponds to the balhimycin precursor after OxyC introduces the second biaryl ether crosslink between hpg5 and dhpg7.	DOI:10.1016/j.jbiotec.2006.04.009 DOI:10.1002/1521-3773(20011217)40:24<4688::AID-ANIE4688>3.0.CO;2-M https://mite.bioinformatics.nl/repository/MITE0000027 https://mibig.secondarymetabolites.org/repository/BGC0000311.6/BGC0000311.gbk https://www.uniprot.org/uniprotkb/O87675 https://www.ncbi.nlm.nih.gov/protein/CAA76549.1 reference DOI:10.1016/j.jbiotec.2006.04.009 evidence type PRIMARY_EXPERIMENT snippet The mutant NPoxyA produces mainly monocyclic, the mutant DeltaoxyB linear and the mutant DeltaoxyC bicyclic peptides notes Stegmann et al. constructed non-polar oxyA, oxyB and oxyC mutants in Amycolatopsis balhimycina, assayed their glycopeptide products by HPLC-ESI-MS, and established OxyC as the final enzyme in the OxyB-OxyA-OxyC oxidative ring-closing sequence. reference DOI:10.1002/1521-3773(20011217)40:24<4688::AID-ANIE4688>3.0.CO;2-M evidence type PRIMARY_EXPERIMENT notes Bischoff et al. analyzed balhimycin oxygenase mutants to establish the order of oxidative cyclization steps in vancomycin-type glycopeptide biosynthesis. reference https://mite.bioinformatics.nl/repository/MITE0000027 evidence type DATABASE_ASSERTION retrieved on 2026-10-02 notes MITE0000027 is active, assigns OxyC to a knock-out-supported cyclization that installs the second biaryl ether crosslink between hpg5 and dhpg7 of a balhimycin precursor, lists heme and Fe as cofactors, and links the enzyme to UniProtKB:O87675, GenPept CAA76549.1 and MIBiG BGC0000311. reference https://mibig.secondarymetabolites.org/repository/BGC0000311.6/BGC0000311.gbk evidence type DATABASE_ASSERTION snippet MITE0000027: Cyclization (89% identity) retrieved on 2026-10-02 notes MIBiG BGC0000311.6 places oxyC/CAA76549.1 inside the active Amycolatopsis balhimycina DSM 5908 balhimycin biosynthetic gene cluster as a P450 monooxygenase locus with a MITE0000027 cyclization annotation. reference https://www.uniprot.org/uniprotkb/O87675 evidence type DATABASE_ASSERTION snippet GN Name=oxyC retrieved on 2026-10-02 notes Current UniProtKB:O87675 resolves as a 406 aa Amycolatopsis balhimycina oxyC p450 monooxygenase entry and cross-references EMBL Y16952 protein CAA76549.1. reference https://www.ncbi.nlm.nih.gov/protein/CAA76549.1 evidence type DATABASE_ASSERTION snippet P450 monooxygenase retrieved on 2026-10-02 notes NCBI Protein CAA76549.1 is the Amycolatopsis balhimycina DSM 5908 oxyC P450 monooxygenase linked to UniProtKB/TrEMBL O87675.

Every edge carries its own citation; an uncited edge is refused by the corpus tests.

Causal graph — biosynthesis 6 nodes, 5 edges

Partial Amycolatopsis balhimycina balhimycin biosynthesis graph for BhaA-catalyzed FAD-dependent beta-hydroxytyrosine chlorination during nonribosomal peptide assembly.

Subject	Predicate	Object	Notes	Evidence
module 2 beta-hydroxytyrosine substrate	is chlorinated by	BhaA FAD-dependent halogenase	MITE represents BhaA as chlorinating the beta-hydroxytyrosine residue of a balhimycin precursor, probably while the substrate is bound to the module 2 PCP domain of the NRPS.	DOI:10.1016/s1074-5521(02)00101-1 DOI:10.1128/JB.186.18.6093-6100.2004 DOI:10.1039/C7SC00460E https://mite.bioinformatics.nl/repository/MITE0000028 https://mibig.secondarymetabolites.org/repository/BGC0000311.6/BGC0000311.gbk https://www.uniprot.org/uniprotkb/O87676 https://www.ncbi.nlm.nih.gov/protein/CAA76550.1 reference DOI:10.1016/s1074-5521(02)00101-1 evidence type PRIMARY_EXPERIMENT snippet accumulated glycosylated but nonchlorinated balhimycin variants notes Puk et al. constructed an in-frame bhaA deletion mutant in the balhimycin producer and showed that deleting BhaA blocks chlorination while retaining production of nonchlorinated glycosylated balhimycin variants. reference DOI:10.1128/JB.186.18.6093-6100.2004 evidence type PRIMARY_EXPERIMENT notes Puk et al. showed by precursor feeding to an oxyD mutant that balhimycin chlorination occurs after free beta-hydroxytyrosine, most likely during heptapeptide assembly. reference DOI:10.1039/C7SC00460E evidence type PRIMARY_EXPERIMENT notes Kittila et al. combined in vivo and in vitro assays of glycopeptide antibiotic halogenases and showed that halogenation acts on amino acid residues bound to nonribosomal peptide synthetase PCP domains rather than on free amino acids or PCP-bound peptides. reference https://mite.bioinformatics.nl/repository/MITE0000028 evidence type DATABASE_ASSERTION retrieved on 2026-10-02 notes MITE0000028 is active, assigns BhaA to two knock-out-supported halogenation rows for balhimycin-precursor beta-hydroxytyrosine chlorination at NRPS modules 2 and 6, lists FAD as an organic cofactor, and links BhaA to UniProtKB:O87676, GenPept CAA76550.1 and MIBiG BGC0000311. reference https://mibig.secondarymetabolites.org/repository/BGC0000311.6/BGC0000311.gbk evidence type DATABASE_ASSERTION snippet MITE0000028: Halogenation (100% identity) retrieved on 2026-10-02 notes MIBiG BGC0000311.6 places bhaA/CAA76550.1 inside the active Amycolatopsis balhimycina DSM 5908 balhimycin biosynthetic gene cluster as a flavin-dependent tyrosine-like Hpg halogenase locus with a MITE0000028 halogenation annotation. reference https://www.uniprot.org/uniprotkb/O87676 evidence type DATABASE_ASSERTION snippet GN Name=bhaA retrieved on 2026-10-02 notes Current UniProtKB:O87676 resolves as a 491 aa Amycolatopsis balhimycina bhaA halogenase entry, cross-references EMBL Y16952 protein CAA76550.1, and carries flavin halogenase domain cross-references. reference https://www.ncbi.nlm.nih.gov/protein/CAA76550.1 evidence type DATABASE_ASSERTION snippet GOA:O87676 retrieved on 2026-10-02 notes NCBI Protein CAA76550.1 is the Amycolatopsis balhimycina DSM 5908 bhaA halogenase encoded by Y16952.3:38634..40109 and linked to GOA:O87676.
BhaA FAD-dependent halogenase	forms	module 2 chlorinated beta-hydroxytyrosine intermediate	The MITE module 2 product adds chlorine to the beta-hydroxytyrosine aryl group of a balhimycin-pathway precursor; the exact substrate and product structures are absent from local records.	DOI:10.1016/s1074-5521(02)00101-1 DOI:10.1128/JB.186.18.6093-6100.2004 DOI:10.1039/C7SC00460E https://mite.bioinformatics.nl/repository/MITE0000028 https://mibig.secondarymetabolites.org/repository/BGC0000311.6/BGC0000311.gbk https://www.uniprot.org/uniprotkb/O87676 https://www.ncbi.nlm.nih.gov/protein/CAA76550.1 reference DOI:10.1016/s1074-5521(02)00101-1 evidence type PRIMARY_EXPERIMENT snippet accumulated glycosylated but nonchlorinated balhimycin variants notes Puk et al. constructed an in-frame bhaA deletion mutant in the balhimycin producer and showed that deleting BhaA blocks chlorination while retaining production of nonchlorinated glycosylated balhimycin variants. reference DOI:10.1128/JB.186.18.6093-6100.2004 evidence type PRIMARY_EXPERIMENT notes Puk et al. showed by precursor feeding to an oxyD mutant that balhimycin chlorination occurs after free beta-hydroxytyrosine, most likely during heptapeptide assembly. reference DOI:10.1039/C7SC00460E evidence type PRIMARY_EXPERIMENT notes Kittila et al. combined in vivo and in vitro assays of glycopeptide antibiotic halogenases and showed that halogenation acts on amino acid residues bound to nonribosomal peptide synthetase PCP domains rather than on free amino acids or PCP-bound peptides. reference https://mite.bioinformatics.nl/repository/MITE0000028 evidence type DATABASE_ASSERTION retrieved on 2026-10-02 notes MITE0000028 is active, assigns BhaA to two knock-out-supported halogenation rows for balhimycin-precursor beta-hydroxytyrosine chlorination at NRPS modules 2 and 6, lists FAD as an organic cofactor, and links BhaA to UniProtKB:O87676, GenPept CAA76550.1 and MIBiG BGC0000311. reference https://mibig.secondarymetabolites.org/repository/BGC0000311.6/BGC0000311.gbk evidence type DATABASE_ASSERTION snippet MITE0000028: Halogenation (100% identity) retrieved on 2026-10-02 notes MIBiG BGC0000311.6 places bhaA/CAA76550.1 inside the active Amycolatopsis balhimycina DSM 5908 balhimycin biosynthetic gene cluster as a flavin-dependent tyrosine-like Hpg halogenase locus with a MITE0000028 halogenation annotation. reference https://www.uniprot.org/uniprotkb/O87676 evidence type DATABASE_ASSERTION snippet GN Name=bhaA retrieved on 2026-10-02 notes Current UniProtKB:O87676 resolves as a 491 aa Amycolatopsis balhimycina bhaA halogenase entry, cross-references EMBL Y16952 protein CAA76550.1, and carries flavin halogenase domain cross-references. reference https://www.ncbi.nlm.nih.gov/protein/CAA76550.1 evidence type DATABASE_ASSERTION snippet GOA:O87676 retrieved on 2026-10-02 notes NCBI Protein CAA76550.1 is the Amycolatopsis balhimycina DSM 5908 bhaA halogenase encoded by Y16952.3:38634..40109 and linked to GOA:O87676.
module 6 beta-hydroxytyrosine substrate	is chlorinated by	BhaA FAD-dependent halogenase	MITE represents a second BhaA reaction that chlorinates the beta-hydroxytyrosine residue of a balhimycin precursor, probably while the substrate is bound to the module 6 PCP domain.	DOI:10.1016/s1074-5521(02)00101-1 DOI:10.1128/JB.186.18.6093-6100.2004 DOI:10.1039/C7SC00460E https://mite.bioinformatics.nl/repository/MITE0000028 https://mibig.secondarymetabolites.org/repository/BGC0000311.6/BGC0000311.gbk https://www.uniprot.org/uniprotkb/O87676 https://www.ncbi.nlm.nih.gov/protein/CAA76550.1 reference DOI:10.1016/s1074-5521(02)00101-1 evidence type PRIMARY_EXPERIMENT snippet accumulated glycosylated but nonchlorinated balhimycin variants notes Puk et al. constructed an in-frame bhaA deletion mutant in the balhimycin producer and showed that deleting BhaA blocks chlorination while retaining production of nonchlorinated glycosylated balhimycin variants. reference DOI:10.1128/JB.186.18.6093-6100.2004 evidence type PRIMARY_EXPERIMENT notes Puk et al. showed by precursor feeding to an oxyD mutant that balhimycin chlorination occurs after free beta-hydroxytyrosine, most likely during heptapeptide assembly. reference DOI:10.1039/C7SC00460E evidence type PRIMARY_EXPERIMENT notes Kittila et al. combined in vivo and in vitro assays of glycopeptide antibiotic halogenases and showed that halogenation acts on amino acid residues bound to nonribosomal peptide synthetase PCP domains rather than on free amino acids or PCP-bound peptides. reference https://mite.bioinformatics.nl/repository/MITE0000028 evidence type DATABASE_ASSERTION retrieved on 2026-10-02 notes MITE0000028 is active, assigns BhaA to two knock-out-supported halogenation rows for balhimycin-precursor beta-hydroxytyrosine chlorination at NRPS modules 2 and 6, lists FAD as an organic cofactor, and links BhaA to UniProtKB:O87676, GenPept CAA76550.1 and MIBiG BGC0000311. reference https://mibig.secondarymetabolites.org/repository/BGC0000311.6/BGC0000311.gbk evidence type DATABASE_ASSERTION snippet MITE0000028: Halogenation (100% identity) retrieved on 2026-10-02 notes MIBiG BGC0000311.6 places bhaA/CAA76550.1 inside the active Amycolatopsis balhimycina DSM 5908 balhimycin biosynthetic gene cluster as a flavin-dependent tyrosine-like Hpg halogenase locus with a MITE0000028 halogenation annotation. reference https://www.uniprot.org/uniprotkb/O87676 evidence type DATABASE_ASSERTION snippet GN Name=bhaA retrieved on 2026-10-02 notes Current UniProtKB:O87676 resolves as a 491 aa Amycolatopsis balhimycina bhaA halogenase entry, cross-references EMBL Y16952 protein CAA76550.1, and carries flavin halogenase domain cross-references. reference https://www.ncbi.nlm.nih.gov/protein/CAA76550.1 evidence type DATABASE_ASSERTION snippet GOA:O87676 retrieved on 2026-10-02 notes NCBI Protein CAA76550.1 is the Amycolatopsis balhimycina DSM 5908 bhaA halogenase encoded by Y16952.3:38634..40109 and linked to GOA:O87676.
BhaA FAD-dependent halogenase	forms	module 6 chlorinated beta-hydroxytyrosine intermediate	The MITE module 6 product adds the second chlorine atom to a balhimycin-pathway precursor; the exact substrate and product structures are absent from local records.	DOI:10.1016/s1074-5521(02)00101-1 DOI:10.1128/JB.186.18.6093-6100.2004 DOI:10.1039/C7SC00460E https://mite.bioinformatics.nl/repository/MITE0000028 https://mibig.secondarymetabolites.org/repository/BGC0000311.6/BGC0000311.gbk https://www.uniprot.org/uniprotkb/O87676 https://www.ncbi.nlm.nih.gov/protein/CAA76550.1 reference DOI:10.1016/s1074-5521(02)00101-1 evidence type PRIMARY_EXPERIMENT snippet accumulated glycosylated but nonchlorinated balhimycin variants notes Puk et al. constructed an in-frame bhaA deletion mutant in the balhimycin producer and showed that deleting BhaA blocks chlorination while retaining production of nonchlorinated glycosylated balhimycin variants. reference DOI:10.1128/JB.186.18.6093-6100.2004 evidence type PRIMARY_EXPERIMENT notes Puk et al. showed by precursor feeding to an oxyD mutant that balhimycin chlorination occurs after free beta-hydroxytyrosine, most likely during heptapeptide assembly. reference DOI:10.1039/C7SC00460E evidence type PRIMARY_EXPERIMENT notes Kittila et al. combined in vivo and in vitro assays of glycopeptide antibiotic halogenases and showed that halogenation acts on amino acid residues bound to nonribosomal peptide synthetase PCP domains rather than on free amino acids or PCP-bound peptides. reference https://mite.bioinformatics.nl/repository/MITE0000028 evidence type DATABASE_ASSERTION retrieved on 2026-10-02 notes MITE0000028 is active, assigns BhaA to two knock-out-supported halogenation rows for balhimycin-precursor beta-hydroxytyrosine chlorination at NRPS modules 2 and 6, lists FAD as an organic cofactor, and links BhaA to UniProtKB:O87676, GenPept CAA76550.1 and MIBiG BGC0000311. reference https://mibig.secondarymetabolites.org/repository/BGC0000311.6/BGC0000311.gbk evidence type DATABASE_ASSERTION snippet MITE0000028: Halogenation (100% identity) retrieved on 2026-10-02 notes MIBiG BGC0000311.6 places bhaA/CAA76550.1 inside the active Amycolatopsis balhimycina DSM 5908 balhimycin biosynthetic gene cluster as a flavin-dependent tyrosine-like Hpg halogenase locus with a MITE0000028 halogenation annotation. reference https://www.uniprot.org/uniprotkb/O87676 evidence type DATABASE_ASSERTION snippet GN Name=bhaA retrieved on 2026-10-02 notes Current UniProtKB:O87676 resolves as a 491 aa Amycolatopsis balhimycina bhaA halogenase entry, cross-references EMBL Y16952 protein CAA76550.1, and carries flavin halogenase domain cross-references. reference https://www.ncbi.nlm.nih.gov/protein/CAA76550.1 evidence type DATABASE_ASSERTION snippet GOA:O87676 retrieved on 2026-10-02 notes NCBI Protein CAA76550.1 is the Amycolatopsis balhimycina DSM 5908 bhaA halogenase encoded by Y16952.3:38634..40109 and linked to GOA:O87676.
FAD	serves as cofactor for	BhaA FAD-dependent halogenase	MITE lists FAD as BhaA's organic cofactor.	https://mite.bioinformatics.nl/repository/MITE0000028 reference https://mite.bioinformatics.nl/repository/MITE0000028 evidence type DATABASE_ASSERTION retrieved on 2026-10-02 notes MITE0000028 lists FAD as BhaA's organic cofactor.

Every edge carries its own citation; an uncited edge is refused by the corpus tests.

Explore across X-Mech

AntibioticMech (balhimycin) ↗ MediaIngredientMech (naturalproductmech:mibig-24dfb3f1a5) ↗ TaxonMech: Amycolatopsis balhimycina DSM 5908 (NCBITaxon:1081091) ↗ PathwayMech (mibig:BGC0000311) ↗

Provenance

Source concept	Source	Version
BGC0000311	MIBIG	6

This page is generated from data/natural_products/amino_acids_and_peptides/balhimycin.yaml, which is generated from the committed inventories. Neither is edited by hand.