berninamycin A
naturalproductmech:mibig-9e0cffb06c MINTED SEEDED
Structure
| Standard InChIKey | CAFFHXXVDGAVPH-DKFXDEMXSA-N |
|---|---|
| SMILES | C/C=C\1/C2=NC(=C(O2)C)C(=O)NC(=C)C(=O)N[C@H](C(=O)NC(=C)C3=NC(=C(O3)C)C(=O)NC(=C)C(=O)NC(=C)C4=NC(=CO4)C5=C(C=CC(=N5)C(=O)NC(=C)C(=O)NC(=C)C(=O)N)C6=NC(=CS6)C(=O)N[C@H](C(=O)N1)[C@@H](C)O)C(C)(C)O |
| Stereochemistry | fully defined |
| Cross-references | npatlas:NPA001733, pubchem:91617669 |
Filing pathway
Amino acids and peptides — computed by NPClassifier npclassifier.gnps2.org@2026-09-07, which is why it is pinned rather than recomputed. The gene cluster's asserted class is ribosomal, from MIBiG.
Producer organisms 2
A claim that this taxon makes the compound. The basis says what the evidence addressed — a knockout and a database assertion are not the same claim.
| Taxon | Basis | Cluster | Evidence |
|---|---|---|---|
| Streptomyces sp. NCBITaxon:1931 |
BGC_CORRELATED | mibig:BGC0002363 | PMID:34617948 |
| Streptomyces bernensis NCBITaxon:1337893 |
SOURCE_ASSERTION | mibig:BGC0001472 | PMID:23650400 |
Occurrences 3
Somebody found the compound in this organism and cited it. That is not a claim that the organism makes it, and nothing here promotes one to the other.
| Taxon | Source | Reference |
|---|---|---|
| Streptomyces NCBITaxon:1883 |
LOTUS | DOI:10.3389/FMICB.2018.03139 |
| Streptomyces bernensis NCBITaxon:1337893 |
LOTUS | DOI:10.1021/JA00447A061 |
| Streptomyces bernensis NCBITaxon:1337893 |
LOTUS | DOI:10.1021/JA00511A049 |
Biosynthetic gene clusters 2
| Accession | Host | Locus evidence | Genome |
|---|---|---|---|
| mibig:BGC0002363 | Streptomyces sp. NCBITaxon:1931 |
CLUSTER_DEMONSTRATED | genbank:MT362006.1 |
| mibig:BGC0001472 | Streptomyces bernensis NCBITaxon:1337893 |
CLUSTER_UNSTATED | genbank:KC894738.1 |
A locus claim and a taxon claim are different questions. Heterologous expression settles the first and leaves the second where the isolation report left it.
Open questions 1
shared-structure — This structure is reported by more than one MIBiG entry: BGC0001472, BGC0002363. Confirm they describe the same compound rather than an upstream cross-reference error.
Provenance
| Source concept | Source | Version |
|---|---|---|
| BGC0002363 | MIBIG | 3 |
| BGC0001472 | MIBIG | 5 |
This page is generated from data/natural_products/amino_acids_and_peptides/berninamycin-a.yaml, which is generated from the committed inventories. Neither is edited by hand.