bleomycin A2
CHEBI:3139 EXACT SEEDED antibacterial
Structure
| Standard InChIKey | OYVAGSVQBOHSSS-UAPAGMARSA-O |
|---|---|
| SMILES | CC1=C(N=C(N=C1N)[C@H](CC(=O)N)NC[C@@H](C(=O)N)N)C(=O)N[C@@H]([C@H](C2=CN=CN2)O[C@H]3[C@H]([C@H]([C@@H]([C@@H](O3)CO)O)O)O[C@@H]4[C@H]([C@H]([C@@H]([C@H](O4)CO)O)OC(=O)N)O)C(=O)N[C@H](C)[C@H]([C@H](C)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCCC5=NC(=CS5)C6=NC(=CS6)C(=O)NCCC[S+](C)C)O |
| Stereochemistry | fully defined |
| Cross-references | npatlas:NPA020036 |
Filing pathway
Amino acids and peptides — computed by NPClassifier npclassifier.gnps2.org@2026-09-07, which is why it is pinned rather than recomputed. The gene cluster's asserted class is nrps, pks, saccharide, from MIBiG.
Producer organisms 1
A claim that this taxon makes the compound. The basis says what the evidence addressed — a knockout and a database assertion are not the same claim.
| Taxon | Basis | Cluster | Evidence |
|---|---|---|---|
| Streptomyces mobaraensis NBRC 13819 = DSM 40847 NCBITaxon:1223523 |
BGC_CHARACTERIZED | mibig:BGC0002350 | PMID:28256838 |
Occurrences 18
Somebody found the compound in this organism and cited it. That is not a claim that the organism makes it, and nothing here promotes one to the other.
| Taxon | Source | Reference |
|---|---|---|
| Streptomyces verticillus NCBITaxon:29309 |
LOTUS | DOI:10.1006/BIOO.1998.1131 |
| Streptomyces verticillus NCBITaxon:29309 |
LOTUS | DOI:10.1006/JMBI.1999.3404 |
| Streptomyces verticillus NCBITaxon:29309 |
LOTUS | DOI:10.1007/S00253-019-09923-8 |
| Streptomyces verticillus NCBITaxon:29309 |
LOTUS | DOI:10.1016/0014-5793(95)00218-X |
| Streptomyces verticillus NCBITaxon:29309 |
LOTUS | DOI:10.1016/0378-1119(94)90627-0 |
| Streptomyces verticillus NCBITaxon:29309 |
LOTUS | DOI:10.1016/J.JINORGBIO.2012.01.015 |
| Streptomyces verticillus NCBITaxon:29309 |
LOTUS | DOI:10.1016/S0014-5793(99)00478-0 |
| Streptomyces verticillus NCBITaxon:29309 |
LOTUS | DOI:10.1016/S1074-5521(00)00011-9 |
| Streptomyces verticillus NCBITaxon:29309 |
LOTUS | DOI:10.1016/S1074-5521(01)00047-3 |
| Streptomyces verticillus NCBITaxon:29309 |
LOTUS | DOI:10.1016/S1074-5521(99)80083-0 |
| Streptomyces verticillus NCBITaxon:29309 |
LOTUS | DOI:10.1074/JBC.M103278200 |
| Streptomyces verticillus NCBITaxon:29309 |
LOTUS | DOI:10.1074/JBC.M804971200 |
| Streptomyces verticillus NCBITaxon:29309 |
LOTUS | DOI:10.1111/J.1574-6968.1997.TB10467.X |
| Streptomyces verticillus NCBITaxon:29309 |
LOTUS | DOI:10.1111/J.1574-6968.2000.TB09225.X |
| Streptomyces verticillus NCBITaxon:29309 |
LOTUS | DOI:10.7164/ANTIBIOTICS.25.755 |
| Streptomyces verticillus NCBITaxon:29309 |
LOTUS | DOI:10.7164/ANTIBIOTICS.52.895 |
| Streptomyces verticillus NCBITaxon:29309 |
CHEBI | PMID:21210656 |
| Streptomyces mobaraensis NCBITaxon:35621 |
LOTUS | DOI:10.1021/ACS.ORGLETT.7B00283 |
Biosynthetic gene clusters 1
| Accession | Host | Locus evidence | Genome |
|---|---|---|---|
| mibig:BGC0002350 | Streptomyces mobaraensis NBRC 13819 = DSM 40847 NCBITaxon:1223523 |
CLUSTER_DEMONSTRATED | genbank:CP072827.1 |
A locus claim and a taxon claim are different questions. Heterologous expression settles the first and leaves the second where the isolation report left it.
Elsewhere in the fleet
- AntibioticMech — CHEBI:3139 (same structure, same inchikey)
Provenance
| Source concept | Source | Version |
|---|---|---|
| BGC0002350 | MIBIG | 2 |
| CHEBI:3139 | CHEBI | 3-star |
This page is generated from data/natural_products/amino_acids_and_peptides/bleomycin-a2.yaml, which is generated from the committed inventories. Neither is edited by hand.