bleomycin A2

CHEBI:3139 EXACT SEEDED antibacterial

What these status tags mean

Curation status describes a workflow state. SEEDED means the record entered through the source-seeding workflow; it does not imply that no later curation occurred. PROPOSED marks an addition awaiting review; REVIEWED records curator sign-off on identity, structure, filing class and producer claims; DEPRECATED retains a superseded or out-of-scope record. These are workflow decisions, not independently verified human review. Agent-assisted contributions may appear in the record history.

Grounding describes the identifier mapping: EXACT uses an ontology identity asserted by the source; MINTED keeps a local identifier when no defensible ontology identity is available; REVIEW_NEEDED flags an exact structure whose ontology identity needs adjudication. The grounding note retains any unresolved alternatives. These tags do not establish the strength of producer or activity evidence.

Structure

Standard InChIKey	OYVAGSVQBOHSSS-UAPAGMARSA-O
SMILES	CC1=C(N=C(N=C1N)[C@H](CC(=O)N)NC[C@@H](C(=O)N)N)C(=O)N[C@@H]([C@H](C2=CN=CN2)O[C@H]3[C@H]([C@H]([C@@H]([C@@H](O3)CO)O)O)O[C@@H]4[C@H]([C@H]([C@@H]([C@H](O4)CO)O)OC(=O)N)O)C(=O)N[C@H](C)[C@H]([C@H](C)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCCC5=NC(=CS5)C6=NC(=CS6)C(=O)NCCC[S+](C)C)O
Stereochemistry	fully defined
Cross-references	npatlas:NPA020036

Filing pathway

Amino acids and peptides — computed by NPClassifier npclassifier.gnps2.org@2026-09-07, which is why it is pinned rather than recomputed. The gene cluster's asserted class is nrps, pks, saccharide, from MIBiG.

Producer organisms 1

A claim that this taxon makes the compound. The basis says what the evidence addressed — a knockout and a database assertion are not the same claim.

Taxon	Basis	Cluster	Evidence
Streptomyces mobaraensis NBRC 13819 = DSM 40847 NCBITaxon:1223523	BGC_CHARACTERIZED	mibig:BGC0002350	PMID:28256838

Occurrences 18

Somebody found the compound in this organism and cited it. That is not a claim that the organism makes it, and nothing here promotes one to the other.

Taxon	Source	Reference
Streptomyces verticillus NCBITaxon:29309	LOTUS	DOI:10.1006/BIOO.1998.1131
Streptomyces verticillus NCBITaxon:29309	LOTUS	DOI:10.1006/JMBI.1999.3404
Streptomyces verticillus NCBITaxon:29309	LOTUS	DOI:10.1007/S00253-019-09923-8
Streptomyces verticillus NCBITaxon:29309	LOTUS	DOI:10.1016/0014-5793(95)00218-X
Streptomyces verticillus NCBITaxon:29309	LOTUS	DOI:10.1016/0378-1119(94)90627-0
Streptomyces verticillus NCBITaxon:29309	LOTUS	DOI:10.1016/J.JINORGBIO.2012.01.015
Streptomyces verticillus NCBITaxon:29309	LOTUS	DOI:10.1016/S0014-5793(99)00478-0
Streptomyces verticillus NCBITaxon:29309	LOTUS	DOI:10.1016/S1074-5521(00)00011-9
Streptomyces verticillus NCBITaxon:29309	LOTUS	DOI:10.1016/S1074-5521(01)00047-3
Streptomyces verticillus NCBITaxon:29309	LOTUS	DOI:10.1016/S1074-5521(99)80083-0
Streptomyces verticillus NCBITaxon:29309	LOTUS	DOI:10.1074/JBC.M103278200
Streptomyces verticillus NCBITaxon:29309	LOTUS	DOI:10.1074/JBC.M804971200
Streptomyces verticillus NCBITaxon:29309	LOTUS	DOI:10.1111/J.1574-6968.1997.TB10467.X
Streptomyces verticillus NCBITaxon:29309	LOTUS	DOI:10.1111/J.1574-6968.2000.TB09225.X
Streptomyces verticillus NCBITaxon:29309	LOTUS	DOI:10.7164/ANTIBIOTICS.25.755
Streptomyces verticillus NCBITaxon:29309	LOTUS	DOI:10.7164/ANTIBIOTICS.52.895
Streptomyces verticillus NCBITaxon:29309	CHEBI	PMID:21210656
Streptomyces mobaraensis NCBITaxon:35621	LOTUS	DOI:10.1021/ACS.ORGLETT.7B00283

Biosynthetic gene clusters 1

Accession	Host	Locus evidence	Genome
mibig:BGC0002350	Streptomyces mobaraensis NBRC 13819 = DSM 40847 NCBITaxon:1223523	CLUSTER_DEMONSTRATED	genbank:CP072827.1

A locus claim and a taxon claim are different questions. Heterologous expression settles the first and leaves the second where the isolation report left it.

Mechanism & Biosynthesis Overview

Elsewhere in the fleet

AntibioticMech — CHEBI:3139 (same structure, same inchikey)

Explore across X-Mech

AntibioticMech (bleomycin A2) ↗ MediaIngredientMech (CHEBI:3139) ↗ TaxonMech: Streptomyces mobaraensis NBRC 13819 = DSM 40847 (NCBITaxon:1223523) ↗ PathwayMech (mibig:BGC0002350) ↗

Provenance

Source concept	Source	Version
BGC0002350	MIBIG	2
CHEBI:3139	CHEBI	3-star

This page is generated from data/natural_products/amino_acids_and_peptides/bleomycin-a2.yaml, which is generated from the committed inventories. Neither is edited by hand.