bleomycin B2
naturalproductmech:mibig-4ceab14858 MINTED SEEDED antibacterial
Structure
| Standard InChIKey | NBLHOLNNKJBEDC-XOGQCRKLSA-N |
|---|---|
| SMILES | CC1=C(N=C(N=C1N)[C@H](CC(=O)N)NC[C@@H](C(=O)N)N)C(=O)N[C@@H]([C@H](C2=CN=CN2)O[C@H]3[C@H]([C@H]([C@@H]([C@@H](O3)CO)O)O)O[C@@H]4[C@H]([C@H]([C@@H]([C@H](O4)CO)O)OC(=O)N)O)C(=O)N[C@H](C)[C@H]([C@H](C)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCCC5=NC(=CS5)C6=NC(=CS6)C(=O)NCCCCN=C(N)N)O |
| Stereochemistry | fully defined |
| Cross-references | npatlas:NPA020040 |
Filing pathway
Amino acids and peptides — computed by NPClassifier npclassifier.gnps2.org@2026-09-07, which is why it is pinned rather than recomputed. The gene cluster's asserted class is nrps, pks, saccharide, from MIBiG.
Producer organisms 1
A claim that this taxon makes the compound. The basis says what the evidence addressed — a knockout and a database assertion are not the same claim.
| Taxon | Basis | Cluster | Evidence |
|---|---|---|---|
| Streptomyces mobaraensis NBRC 13819 = DSM 40847 NCBITaxon:1223523 |
BGC_CHARACTERIZED | mibig:BGC0002350 | PMID:28256838 |
Occurrences 2
Somebody found the compound in this organism and cited it. That is not a claim that the organism makes it, and nothing here promotes one to the other.
| Taxon | Source | Reference |
|---|---|---|
| Streptomyces verticillus NCBITaxon:29309 |
LOTUS | DOI:10.1007/S00253-019-09923-8 |
| Streptomyces verticillus NCBITaxon:29309 |
LOTUS | DOI:10.7164/ANTIBIOTICS.25.755 |
Biosynthetic gene clusters 1
| Accession | Host | Locus evidence | Genome |
|---|---|---|---|
| mibig:BGC0002350 | Streptomyces mobaraensis NBRC 13819 = DSM 40847 NCBITaxon:1223523 |
CLUSTER_DEMONSTRATED | genbank:CP072827.1 |
A locus claim and a taxon claim are different questions. Heterologous expression settles the first and leaves the second where the isolation report left it.
Elsewhere in the fleet
- AntibioticMech — antibioticmech:aro-e05426a76f (same structure, same inchikey)
Provenance
| Source concept | Source | Version |
|---|---|---|
| BGC0002350 | MIBIG | 2 |
This page is generated from data/natural_products/amino_acids_and_peptides/bleomycin-b2.yaml, which is generated from the committed inventories. Neither is edited by hand.