bleomycin
naturalproductmech:mibig-8b023d76df MINTED SEEDED cytotoxic
Structure
| Standard InChIKey | OYVAGSVQBOHSSS-UHFFFAOYSA-O |
|---|---|
| SMILES | CC1=C(N=C(N=C1N)C(CC(=O)N)NCC(C(=O)N)N)C(=O)NC(C(C2=CN=CN2)OC3C(C(C(C(O3)CO)O)O)OC4C(C(C(C(O4)CO)O)OC(=O)N)O)C(=O)NC(C)C(C(C)C(=O)NC(C(C)O)C(=O)NCCC5=NC(=CS5)C6=NC(=CS6)C(=O)NCCC[S+](C)C)O |
| Stereochemistry | undefined stereocentres — the InChIKey does not distinguish this compound from its stereoisomers |
| Cross-references | pubchem:84068, npatlas:NPA020036 |
Filing pathway
Amino acids and peptides — computed by NPClassifier npclassifier.gnps2.org@2026-09-07, which is why it is pinned rather than recomputed. The gene cluster's asserted class is nrps, pks, saccharide, from MIBiG.
Producer organisms 1
A claim that this taxon makes the compound. The basis says what the evidence addressed — a knockout and a database assertion are not the same claim.
| Taxon | Basis | Cluster | Evidence |
|---|---|---|---|
| Streptomyces verticillus NCBITaxon:29309 |
BGC_CHARACTERIZED | mibig:BGC0000963 | PMID:10421758 |
Occurrences 0
None cited.
Biosynthetic gene clusters 1
| Accession | Host | Locus evidence | Genome |
|---|---|---|---|
| mibig:BGC0000963 | Streptomyces verticillus NCBITaxon:29309 |
CLUSTER_DEMONSTRATED | genbank:AF210249.1 |
A locus claim and a taxon claim are different questions. Heterologous expression settles the first and leaves the second where the isolation report left it.
Bioactivities 1
| Assay | Result | Reference |
|---|---|---|
| NCI In Vivo Anticancer Drug Screen. Data for tumor model P388 Leukemia (intraperitoneal) in B6D2F1 (BDF1) mice | ACTIVE | pubchem.aid:328 |
Provenance
| Source concept | Source | Version |
|---|---|---|
| BGC0000963 | MIBIG | 5 |
This page is generated from data/natural_products/amino_acids_and_peptides/bleomycin.yaml, which is generated from the committed inventories. Neither is edited by hand.