bleomycin

naturalproductmech:mibig-8b023d76df MINTED SEEDED cytotoxic

Grounding review: No 3-star ChEBI entry shares this structure, so the record keeps a content-hashed identifier.

What these status tags mean

Curation status describes a workflow state. SEEDED means the record entered through the source-seeding workflow; it does not imply that no later curation occurred. PROPOSED marks an addition awaiting review; REVIEWED records curator sign-off on identity, structure, filing class and producer claims; DEPRECATED retains a superseded or out-of-scope record. These are workflow decisions, not independently verified human review. Agent-assisted contributions may appear in the record history.

Grounding describes the identifier mapping: EXACT uses an ontology identity asserted by the source; MINTED keeps a local identifier when no defensible ontology identity is available; REVIEW_NEEDED flags an exact structure whose ontology identity needs adjudication. The grounding note retains any unresolved alternatives. These tags do not establish the strength of producer or activity evidence.

Structure

Standard InChIKey	OYVAGSVQBOHSSS-UHFFFAOYSA-O
SMILES	CC1=C(N=C(N=C1N)C(CC(=O)N)NCC(C(=O)N)N)C(=O)NC(C(C2=CN=CN2)OC3C(C(C(C(O3)CO)O)O)OC4C(C(C(C(O4)CO)O)OC(=O)N)O)C(=O)NC(C)C(C(C)C(=O)NC(C(C)O)C(=O)NCCC5=NC(=CS5)C6=NC(=CS6)C(=O)NCCC[S+](C)C)O
Stereochemistry	undefined stereocentres — the InChIKey does not distinguish this compound from its stereoisomers
Cross-references	pubchem:84068, npatlas:NPA020036

Filing pathway

Amino acids and peptides — computed by NPClassifier npclassifier.gnps2.org@2026-09-07, which is why it is pinned rather than recomputed. The gene cluster's asserted class is nrps, pks, saccharide, from MIBiG.

Producer organisms 1

A claim that this taxon makes the compound. The basis says what the evidence addressed — a knockout and a database assertion are not the same claim.

Taxon	Basis	Cluster	Evidence
Streptomyces verticillus NCBITaxon:29309	BGC_CHARACTERIZED	mibig:BGC0000963	PMID:10421758

Occurrences 0

None cited.

Biosynthetic gene clusters 1

Accession	Host	Locus evidence	Genome
mibig:BGC0000963	Streptomyces verticillus NCBITaxon:29309	CLUSTER_DEMONSTRATED	genbank:AF210249.1

A locus claim and a taxon claim are different questions. Heterologous expression settles the first and leaves the second where the isolation report left it.

Mechanism & Biosynthesis Overview

Bioactivities 1

Entries preserve source qualifiers, targets and evidence. Repeated assay names or values are not independent replications; inspect source detail for differences.

Assay	Result	Target enzyme	Source detail
NCI In Vivo Anticancer Drug Screen. Data for tumor model P388 Leukemia (intraperitoneal) in B6D2F1 (BDF1) mice	ACTIVE	Not recorded	pubchem.aid:328 assay NCI In Vivo Anticancer Drug Screen. Data for tumor model P388 Leukemia (intraperitoneal) in B6D2F1 (BDF1) mice evidence reference pubchem.aid:328 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 328, deposited by DTP/NCI; assay type Other. call ACTIVE activity class CYTOTOXIC

Explore across X-Mech

AntibioticMech (bleomycin) ↗ MediaIngredientMech (naturalproductmech:mibig-8b023d76df) ↗ TaxonMech: Streptomyces verticillus (NCBITaxon:29309) ↗ PathwayMech (mibig:BGC0000963) ↗

Provenance

Source concept	Source	Version
BGC0000963	MIBIG	5

This page is generated from data/natural_products/amino_acids_and_peptides/bleomycin.yaml, which is generated from the committed inventories. Neither is edited by hand.