bottromycin A2
naturalproductmech:mibig-d717cc8774 MINTED SEEDED
Structure
| Standard InChIKey | KSIZLOPUXFSFNR-XZNJZDOZSA-N |
|---|---|
| SMILES | [H][C@@]12[C@H](C)CCN1C(=O)CN\C(=N/[C@H](C(=O)N[C@@H]([C@@H](C)C1=CC=CC=C1)C(=O)N[C@H](CC(=O)OC)C1=NC=CS1)C(C)(C)C)[C@@H](NC(=O)[C@@H](NC2=O)C(C)C)C(C)(C)C |
| Stereochemistry | fully defined |
| Cross-references | npatlas:NPA04746, pubchem:3081434 |
Filing pathway
Amino acids and peptides — computed by NPClassifier npclassifier.gnps2.org@2026-09-07, which is why it is pinned rather than recomputed. The gene cluster's asserted class is ribosomal, from MIBiG.
Producer organisms 2
A claim that this taxon makes the compound. The basis says what the evidence addressed — a knockout and a database assertion are not the same claim.
| Taxon | Basis | Cluster | Evidence |
|---|---|---|---|
| Streptomyces bottropensis DSM40262 NCBITaxon:42235 |
BGC_CHARACTERIZED | mibig:BGC0000468 | PMID:19115340 |
| Streptomyces sp. BC16019 NCBITaxon:1109705 |
SOURCE_ASSERTION | mibig:BGC0000469 | PMID:23021914 |
Occurrences 0
None cited.
Biosynthetic gene clusters 2
| Accession | Host | Locus evidence | Genome |
|---|---|---|---|
| mibig:BGC0000468 | Streptomyces bottropensis DSM40262 NCBITaxon:42235 |
CLUSTER_DEMONSTRATED | genbank:HE983629.1 |
| mibig:BGC0000469 | Streptomyces sp. BC16019 NCBITaxon:1109705 |
CLUSTER_DEMONSTRATED | genbank:JX235926.1 |
A locus claim and a taxon claim are different questions. Heterologous expression settles the first and leaves the second where the isolation report left it.
Open questions 1
shared-structure — This structure is reported by more than one MIBiG entry: BGC0000468, BGC0000469. Confirm they describe the same compound rather than an upstream cross-reference error.
Provenance
| Source concept | Source | Version |
|---|---|---|
| BGC0000468 | MIBIG | 5 |
| BGC0000469 | MIBIG | 6 |
This page is generated from data/natural_products/amino_acids_and_peptides/bottromycin-a2-2.yaml, which is generated from the committed inventories. Neither is edited by hand.