colistin A

CHEBI:59064 EXACT SEEDED antibacterial

What these status tags mean

Curation status describes a workflow state. SEEDED means the record entered through the source-seeding workflow; it does not imply that no later curation occurred. PROPOSED marks an addition awaiting review; REVIEWED records curator sign-off on identity, structure, filing class and producer claims; DEPRECATED retains a superseded or out-of-scope record. These are workflow decisions, not independently verified human review. Agent-assisted contributions may appear in the record history.

Grounding describes the identifier mapping: EXACT uses an ontology identity asserted by the source; MINTED keeps a local identifier when no defensible ontology identity is available; REVIEW_NEEDED flags an exact structure whose ontology identity needs adjudication. The grounding note retains any unresolved alternatives. These tags do not establish the strength of producer or activity evidence.

A polymyxin having a (6R)-6-methyloctanoyl group at the amino terminus.

Structure

Standard InChIKey	XDJYMJULXQKGMM-RVYUQJQSSA-N
SMILES	CC[C@@H](C)CCCCC(=O)N[C@@H](CCN)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCN)C(=O)N[C@H]1CCNC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@@H](NC1=O)CCN)CC(C)C)CC(C)C)CCN)CCN)[C@@H](C)O
Stereochemistry	fully defined
Cross-references	pubchem:202195

Filing pathway

Amino acids and peptides — computed by NPClassifier npclassifier.gnps2.org@2026-09-07, which is why it is pinned rather than recomputed. The gene cluster's asserted class is nrps, from MIBiG.

Producer organisms 1

A claim that this taxon makes the compound. The basis says what the evidence addressed — a knockout and a database assertion are not the same claim.

Taxon	Basis	Cluster	Evidence
Paenibacillus alvei NCBITaxon:44250	SOURCE_ASSERTION	mibig:BGC0001192	PMID:25609230

Occurrences 0

None cited.

Biosynthetic gene clusters 1

Accession	Host	Locus evidence	Genome
mibig:BGC0001192	Paenibacillus alvei NCBITaxon:44250	CLUSTER_UNSTATED	genbank:KP262070.1

A locus claim and a taxon claim are different questions. Heterologous expression settles the first and leaves the second where the isolation report left it.

Mechanism & Biosynthesis Overview

Elsewhere in the fleet

AntibioticMech — CHEBI:59064 (same structure, same inchikey)

Explore across X-Mech

AntibioticMech (colistin A) ↗ MediaIngredientMech (CHEBI:59064) ↗ TaxonMech: Paenibacillus alvei (NCBITaxon:44250) ↗ PathwayMech (mibig:BGC0001192) ↗

Provenance

Source concept	Source	Version
BGC0001192	MIBIG	5
CHEBI:59064	CHEBI	3-star

This page is generated from data/natural_products/amino_acids_and_peptides/colistin-a.yaml, which is generated from the committed inventories. Neither is edited by hand.