curacomycin
CHEBI:156426 EXACT SEEDED antibacterial
What these status tags mean
Curation status describes a workflow state. SEEDED means the record entered through the source-seeding workflow; it does not imply that no later curation occurred. PROPOSED marks an addition awaiting review; REVIEWED records curator sign-off on identity, structure, filing class and producer claims; DEPRECATED retains a superseded or out-of-scope record. These are workflow decisions, not independently verified human review. Agent-assisted contributions may appear in the record history.
Grounding describes the identifier mapping: EXACT uses an ontology identity asserted by the source; MINTED keeps a local identifier when no defensible ontology identity is available; REVIEW_NEEDED flags an exact structure whose ontology identity needs adjudication. The grounding note retains any unresolved alternatives. These tags do not establish the strength of producer or activity evidence.
A homodetic cyclic peptide found in several Streptomyces species, consisting of 3-hydroxyasparagine, L-ornithine, L-isoleucine, D-leucine, D-valine and 5-chloro-L-tryptophan joined in sequence in a cyclic arrangement by peptide linkages. It exhibits antibacterial properties.
Structure
| Standard InChIKey | CUXAULQHGRSWLF-IKVCUCANSA-N |
|---|---|
| SMILES | CC[C@H](C)[C@@H]3NC(=O)[C@@H](CC(C)C)NC(=O)[C@@H](C(C)C)NC(=O)[C@H](Cc1c[nH]c2ccc(Cl)cc12)NC(=O)C(C(O)C(N)=O)NC(=O)[C@H](CCCN)NC3=O |
| Stereochemistry | undefined stereocentres — the InChIKey does not distinguish this compound from its stereoisomers |
Filing pathway
Amino acids and peptides — computed by NPClassifier npclassifier.gnps2.org@2026-09-07, which is why it is pinned rather than recomputed. The gene cluster's asserted class is nrps, from MIBiG.
Producer organisms 2
A claim that this taxon makes the compound. The basis says what the evidence addressed — a knockout and a database assertion are not the same claim.
| Taxon | Basis | Cluster | Evidence |
|---|---|---|---|
| Streptomyces curacoi NCBITaxon:146536 |
SOURCE_ASSERTION | mibig:BGC0001561 | DOI:10.1002/ajoc.201700433 |
| Streptomyces curacoi NCBITaxon:146536 |
SOURCE_ASSERTION | mibig:BGC0001562 | DOI:10.1002/ajoc.201700433 |
Occurrences 3
Somebody found the compound in this organism and cited it. That is not a claim that the organism makes it, and nothing here promotes one to the other.
| Taxon | Source | Reference |
|---|---|---|
| Streptomyces noursei NCBITaxon:1971 |
CHEBI | 10.1002/ajoc.201700433 |
| Streptomyces curacoi NCBITaxon:146536 |
CHEBI | 10.1002/ajoc.201700433 |
| Streptomyces curacoi NCBITaxon:146536 |
LOTUS | DOI:10.1002/AJOC.201700433 |
Biosynthetic gene clusters 2
| Accession | Host | Locus evidence | Genome |
|---|---|---|---|
| mibig:BGC0001561 | Streptomyces curacoi NCBITaxon:146536 |
CLUSTER_UNSTATED | genbank:LMWJ01000028.1 |
| mibig:BGC0001562 | Streptomyces curacoi NCBITaxon:146536 |
CLUSTER_UNSTATED | genbank:LMWJ01000003.1 |
A locus claim and a taxon claim are different questions. Heterologous expression settles the first and leaves the second where the isolation report left it.
Mechanism & Biosynthesis Overview
Elsewhere in the fleet
- AntibioticMech — CHEBI:156426 (same structure, same inchikey)
Explore across X-Mech
Open questions 1
shared-structure — This structure is reported by more than one MIBiG entry: BGC0001561, BGC0001562. Confirm they describe the same compound rather than an upstream cross-reference error.
Provenance
| Source concept | Source | Version |
|---|---|---|
| BGC0001561 | MIBIG | 4 |
| BGC0001562 | MIBIG | 5 |
| CHEBI:156426 | CHEBI | 3-star |
This page is generated from data/natural_products/amino_acids_and_peptides/curacomycin.yaml, which is generated from the committed inventories. Neither is edited by hand.