cycloserine

naturalproductmech:mibig-415a4f90e6 REVIEW_NEEDED SEEDED antimycobacterial

Grounding review: This structure matches more than one 3-star ChEBI entry: CHEBI:40009, CHEBI:74159. ChEBI keeps such entries separate on purpose — a compound and its zwitterion share an InChIKey — so the identity is not picked here. A curator decides which term this record is.

What these status tags mean

Curation status describes a workflow state. SEEDED means the record entered through the source-seeding workflow; it does not imply that no later curation occurred. PROPOSED marks an addition awaiting review; REVIEWED records curator sign-off on identity, structure, filing class and producer claims; DEPRECATED retains a superseded or out-of-scope record. These are workflow decisions, not independently verified human review. Agent-assisted contributions may appear in the record history.

Grounding describes the identifier mapping: EXACT uses an ontology identity asserted by the source; MINTED keeps a local identifier when no defensible ontology identity is available; REVIEW_NEEDED flags an exact structure whose ontology identity needs adjudication. The grounding note retains any unresolved alternatives. These tags do not establish the strength of producer or activity evidence.

Structure

Standard InChIKey	DYDCUQKUCUHJBH-UWTATZPHSA-N
SMILES	N[C@@H]1CONC1=O
Stereochemistry	fully defined
Cross-references	npatlas:NPA01237

Filing pathway

Amino acids and peptides — computed by NPClassifier npclassifier.gnps2.org@2026-09-07, which is why it is pinned rather than recomputed. The gene cluster's asserted class is other, from MIBiG.

Producer organisms 1

A claim that this taxon makes the compound. The basis says what the evidence addressed — a knockout and a database assertion are not the same claim.

Taxon	Basis	Cluster	Evidence
Streptomyces lavendulae subsp. lavendulae NCBITaxon:58340	SOURCE_ASSERTION	mibig:BGC0000896	PMID:20086163

Occurrences 7

Somebody found the compound in this organism and cited it. That is not a claim that the organism makes it, and nothing here promotes one to the other.

Taxon	Source	Reference
Streptomyces lavendulae NCBITaxon:1914	LOTUS	DOI:10.1007/S00253-014-5988-9
Streptomyces lavendulae NCBITaxon:1914	LOTUS	DOI:10.1016/J.GENE.2008.07.043
Streptomyces lavendulae NCBITaxon:1914	LOTUS	DOI:10.1016/J.JBIOSC.2015.08.013
Streptomyces lavendulae NCBITaxon:1914	LOTUS	DOI:10.1074/JBC.M404603200
Streptomyces lavendulae NCBITaxon:1914	LOTUS	DOI:10.1074/JBC.M611319200
Streptomyces lavendulae NCBITaxon:1914	LOTUS	DOI:10.1128/AAC.01226-09
Streptomyces garyphalus NCBITaxon:235466	LOTUS	DOI:10.1007/BF01053994

Biosynthetic gene clusters 1

Accession	Host	Locus evidence	Genome
mibig:BGC0000896	Streptomyces lavendulae subsp. lavendulae NCBITaxon:58340	CLUSTER_UNSTATED	genbank:AB516431.1

A locus claim and a taxon claim are different questions. Heterologous expression settles the first and leaves the second where the isolation report left it.

Mechanism & Biosynthesis Overview

Elsewhere in the fleet

AntibioticMech — CHEBI:40009 (same structure, same inchikey)

Explore across X-Mech

AntibioticMech (cycloserine) ↗ MediaIngredientMech (naturalproductmech:mibig-415a4f90e6) ↗ TaxonMech: Streptomyces lavendulae subsp. lavendulae (NCBITaxon:58340) ↗ PathwayMech (mibig:BGC0000896) ↗

Provenance

Source concept	Source	Version
BGC0000896	MIBIG	5
CHEBI:40009	CHEBI	3-star
CHEBI:74159	CHEBI	3-star

This page is generated from data/natural_products/amino_acids_and_peptides/cycloserine.yaml, which is generated from the committed inventories. Neither is edited by hand.