cyclothiazomycin C
naturalproductmech:mibig-349529d158 MINTED SEEDED
What these status tags mean
Curation status describes a workflow state. SEEDED means the record entered through the source-seeding workflow; it does not imply that no later curation occurred. PROPOSED marks an addition awaiting review; REVIEWED records curator sign-off on identity, structure, filing class and producer claims; DEPRECATED retains a superseded or out-of-scope record. These are workflow decisions, not independently verified human review. Agent-assisted contributions may appear in the record history.
Grounding describes the identifier mapping: EXACT uses an ontology identity asserted by the source; MINTED keeps a local identifier when no defensible ontology identity is available; REVIEW_NEEDED flags an exact structure whose ontology identity needs adjudication. The grounding note retains any unresolved alternatives. These tags do not establish the strength of producer or activity evidence.
Structure
| Standard InChIKey | ZUDMXUJOZNUCIR-XRARMUINSA-N |
|---|---|
| SMILES | O=C([C@H]1CSC(C2=CSC(C3=CSC(C(NC([C@@H]4CSC(C5=CSC(C6=CC=C(C(N[C@@H](CC(N)=O)C7=N[C@H](C(N/C8=C\C)=O)CS7)=O)C([C@H](NC9=O)C)=N6)=N5)=N4)=O)=C)=N3)=N2)=N1)N[C@H](C(O)=O)CS[C@@](C)(C(N[C@@H](CCCCN)C(NCC(NC(C(N%10[C@H]9CCC%10)=O)=C)=O)=O)=O)NC8=O |
| Stereochemistry | fully defined |
| Cross-references | pubchem:130317475 |
Filing pathway
Amino acids and peptides — computed by NPClassifier npclassifier.gnps2.org@2026-09-07, which is why it is pinned rather than recomputed. The gene cluster's asserted class is ribosomal, from MIBiG.
Producer organisms 1
A claim that this taxon makes the compound. The basis says what the evidence addressed — a knockout and a database assertion are not the same claim.
| Taxon | Basis | Cluster | Evidence |
|---|---|---|---|
| Streptomyces sp. NRRL WC-3908 NCBITaxon:1509516 |
SOURCE_ASSERTION | mibig:BGC0001146 | PMID:24937678 |
Occurrences 1
Somebody found the compound in this organism and cited it. That is not a claim that the organism makes it, and nothing here promotes one to the other.
| Taxon | Source | Reference |
|---|---|---|
| Streptomyces rimosus NCBITaxon:1927 |
LOTUS | DOI:10.1021/CB500324N |
Biosynthetic gene clusters 1
| Accession | Host | Locus evidence | Genome |
|---|---|---|---|
| mibig:BGC0001146 | Streptomyces sp. NRRL WC-3908 NCBITaxon:1509516 |
CLUSTER_UNSTATED | genbank:KJ651958.1 |
A locus claim and a taxon claim are different questions. Heterologous expression settles the first and leaves the second where the isolation report left it.
Mechanism & Biosynthesis Overview
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Provenance
| Source concept | Source | Version |
|---|---|---|
| BGC0001146 | MIBIG | 5 |
This page is generated from data/natural_products/amino_acids_and_peptides/cyclothiazomycin-c.yaml, which is generated from the committed inventories. Neither is edited by hand.