echinocandin B
CHEBI:315018 EXACT SEEDED antifungal
What these status tags mean
Curation status describes a workflow state. SEEDED means the record entered through the source-seeding workflow; it does not imply that no later curation occurred. PROPOSED marks an addition awaiting review; REVIEWED records curator sign-off on identity, structure, filing class and producer claims; DEPRECATED retains a superseded or out-of-scope record. These are workflow decisions, not independently verified human review. Agent-assisted contributions may appear in the record history.
Grounding describes the identifier mapping: EXACT uses an ontology identity asserted by the source; MINTED keeps a local identifier when no defensible ontology identity is available; REVIEW_NEEDED flags an exact structure whose ontology identity needs adjudication. The grounding note retains any unresolved alternatives. These tags do not establish the strength of producer or activity evidence.
A cyclic hexapeptide echinocandin antibiotic isolated from Aspergillus nidulans var. echinulatus with specific anti-yeast activity.
Structure
| Standard InChIKey | FAUOJMHVEYMQQG-HVYQDZECSA-N |
|---|---|
| SMILES | CCCCC/C=C\C/C=C\CCCCCCCC(=O)N[C@H]1C[C@H]([C@H](NC(=O)[C@@H]2[C@H]([C@H](CN2C(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H]3C[C@H](CN3C(=O)[C@@H](NC1=O)[C@@H](C)O)O)[C@@H]([C@H](C4=CC=C(C=C4)O)O)O)[C@@H](C)O)C)O)O)O |
| Stereochemistry | fully defined |
| Cross-references | pubchem:9898144 |
Filing pathway
Amino acids and peptides — computed by NPClassifier npclassifier.gnps2.org@2026-09-07, which is why it is pinned rather than recomputed. The gene cluster's asserted class is nrps, from MIBiG.
Producer organisms 1
A claim that this taxon makes the compound. The basis says what the evidence addressed — a knockout and a database assertion are not the same claim.
| Taxon | Basis | Cluster | Evidence |
|---|---|---|---|
| Aspergillus nidulans NRRL 8112 NCBITaxon:1160106 |
SOURCE_ASSERTION | mibig:BGC0001371 | DOI:10.1002/hlca.19740570818 |
Occurrences 3
Somebody found the compound in this organism and cited it. That is not a claim that the organism makes it, and nothing here promotes one to the other.
| Taxon | Source | Reference |
|---|---|---|
| Aspergillus nidulans NCBITaxon:162425 |
LOTUS | DOI:10.1186/S12864-016-2885-X |
| Aspergillus spinulosporus NCBITaxon:1810908 |
LOTUS | DOI:10.1002/HLCA.19740570818 |
| Streptomyces NCBITaxon:1883 |
LOTUS | DOI:10.1007/S13205-019-1946-7 |
Biosynthetic gene clusters 1
| Accession | Host | Locus evidence | Genome |
|---|---|---|---|
| mibig:BGC0001371 | Aspergillus nidulans NRRL 8112 NCBITaxon:1160106 |
CLUSTER_UNSTATED | genbank:KT806042.1 |
A locus claim and a taxon claim are different questions. Heterologous expression settles the first and leaves the second where the isolation report left it.
Mechanism & Biosynthesis Overview
Elsewhere in the fleet
- AntibioticMech — CHEBI:315018 (same structure, same inchikey)
Explore across X-Mech
Provenance
| Source concept | Source | Version |
|---|---|---|
| BGC0001371 | MIBIG | 4 |
| CHEBI:315018 | CHEBI | 3-star |
This page is generated from data/natural_products/amino_acids_and_peptides/echinocandin-b.yaml, which is generated from the committed inventories. Neither is edited by hand.