feglymycin
naturalproductmech:mibig-01731d46ec MINTED SEEDED
Structure
| Standard InChIKey | QJQKBRUTBCTBKE-UHFFFAOYSA-N |
|---|---|
| SMILES | CC(C)C(NC(=O)C(NC(=O)C(N)C1=CC=C(O)C=C1)C1=CC(O)=CC(O)=C1)C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(C)C)C(=O)NC(C(=O)NC(C(=O)NC(CC1=CC=CC=C1)C(=O)NC(CC(O)=O)C(O)=O)C1=CC=C(O)C=C1)C1=CC(O)=CC(O)=C1)C1=CC(O)=CC(O)=C1)C1=CC=C(O)C=C1)C1=CC(O)=CC(O)=C1)C1=CC=C(O)C=C1)C1=CC(O)=CC(O)=C1 |
| Stereochemistry | undefined stereocentres — the InChIKey does not distinguish this compound from its stereoisomers |
| Cross-references | npatlas:NPA02530 |
Filing pathway
Amino acids and peptides — computed by NPClassifier npclassifier.gnps2.org@2026-09-07, which is why it is pinned rather than recomputed. The gene cluster's asserted class is nrps, from MIBiG.
Producer organisms 1
A claim that this taxon makes the compound. The basis says what the evidence addressed — a knockout and a database assertion are not the same claim.
| Taxon | Basis | Cluster | Evidence |
|---|---|---|---|
| Streptomyces sp. DSM 11171 NCBITaxon:1740725 |
SOURCE_ASSERTION | mibig:BGC0001233 | PMID:26515424 |
Occurrences 0
None cited.
Biosynthetic gene clusters 1
| Accession | Host | Locus evidence | Genome |
|---|---|---|---|
| mibig:BGC0001233 | Streptomyces sp. DSM 11171 NCBITaxon:1740725 |
CLUSTER_UNSTATED | genbank:KT809366.1 |
A locus claim and a taxon claim are different questions. Heterologous expression settles the first and leaves the second where the isolation report left it.
Causal graph — bioactivity 3 nodes, 2 edges
Feglymycin inhibits bacterial UDP-N-acetylglucosamine 1-carboxyvinyltransferases.
| Subject | Predicate | Object | Evidence |
|---|---|---|---|
| feglymycin | inhibits | Escherichia coli K-12 UDP-N-acetylglucosamine 1-carboxyvinyltransferase | DOI:10.1016/j.bioorg.2014.03.008 |
| feglymycin | inhibits | Staphylococcus aureus Mu50 UDP-N-acetylglucosamine 1-carboxyvinyltransferase 2 | DOI:10.1016/j.bioorg.2014.03.008 |
Every edge carries its own citation; an uncited edge is refused by the corpus tests.
Molecular targets 2
| Target | Assay organism | Measurement | Reference |
|---|---|---|---|
| UDP-N-acetylglucosamine 1-carboxyvinyltransferase UniProtKB:P0A749 |
Escherichia coli (strain K12) NCBITaxon:83333 |
KI 3400 nM | PMID:24755374 |
| UDP-N-acetylglucosamine 1-carboxyvinyltransferase 2 UniProtKB:P65456 |
Staphylococcus aureus (strain Mu50 / ATCC 700699) NCBITaxon:158878 |
KI 3500 nM | PMID:24755374 |
Provenance
| Source concept | Source | Version |
|---|---|---|
| BGC0001233 | MIBIG | 5 |
This page is generated from data/natural_products/amino_acids_and_peptides/feglymycin.yaml, which is generated from the committed inventories. Neither is edited by hand.