feglymycin

naturalproductmech:mibig-01731d46ec MINTED SEEDED

Grounding review: No 3-star ChEBI entry shares this structure, so the record keeps a content-hashed identifier.

What these status tags mean

Curation status describes a workflow state. SEEDED means the record entered through the source-seeding workflow; it does not imply that no later curation occurred. PROPOSED marks an addition awaiting review; REVIEWED records curator sign-off on identity, structure, filing class and producer claims; DEPRECATED retains a superseded or out-of-scope record. These are workflow decisions, not independently verified human review. Agent-assisted contributions may appear in the record history.

Grounding describes the identifier mapping: EXACT uses an ontology identity asserted by the source; MINTED keeps a local identifier when no defensible ontology identity is available; REVIEW_NEEDED flags an exact structure whose ontology identity needs adjudication. The grounding note retains any unresolved alternatives. These tags do not establish the strength of producer or activity evidence.

Structure

Standard InChIKey	QJQKBRUTBCTBKE-UHFFFAOYSA-N
SMILES	CC(C)C(NC(=O)C(NC(=O)C(N)C1=CC=C(O)C=C1)C1=CC(O)=CC(O)=C1)C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(C)C)C(=O)NC(C(=O)NC(C(=O)NC(CC1=CC=CC=C1)C(=O)NC(CC(O)=O)C(O)=O)C1=CC=C(O)C=C1)C1=CC(O)=CC(O)=C1)C1=CC(O)=CC(O)=C1)C1=CC=C(O)C=C1)C1=CC(O)=CC(O)=C1)C1=CC=C(O)C=C1)C1=CC(O)=CC(O)=C1
Stereochemistry	undefined stereocentres — the InChIKey does not distinguish this compound from its stereoisomers
Cross-references	npatlas:NPA02530

Filing pathway

Amino acids and peptides — computed by NPClassifier npclassifier.gnps2.org@2026-09-07, which is why it is pinned rather than recomputed. The gene cluster's asserted class is nrps, from MIBiG.

Producer organisms 1

A claim that this taxon makes the compound. The basis says what the evidence addressed — a knockout and a database assertion are not the same claim.

Taxon	Basis	Cluster	Evidence
Streptomyces sp. DSM 11171 NCBITaxon:1740725	SOURCE_ASSERTION	mibig:BGC0001233	PMID:26515424

Occurrences 0

None cited.

Biosynthetic gene clusters 1

Accession	Host	Locus evidence	Genome
mibig:BGC0001233	Streptomyces sp. DSM 11171 NCBITaxon:1740725	CLUSTER_UNSTATED	genbank:KT809366.1

A locus claim and a taxon claim are different questions. Heterologous expression settles the first and leaves the second where the isolation report left it.

Mechanism & Biosynthesis Overview

Causal graph — bioactivity 3 nodes, 2 edges

Feglymycin inhibits bacterial UDP-N-acetylglucosamine 1-carboxyvinyltransferases.

Subject	Predicate	Object	Notes	Evidence
feglymycin	inhibits	Escherichia coli K-12 UDP-N-acetylglucosamine 1-carboxyvinyltransferase	BindingDB maps this exact Standard InChIKey to a 3400 nM Ki measurement against Escherichia coli K-12 MurA, and P0A749 resolves in UniProtKB to the K-12 murA gene product.	DOI:10.1016/j.bioorg.2014.03.008 reference DOI:10.1016/j.bioorg.2014.03.008 evidence type DATABASE_ASSERTION notes BindingDB own-curated row 83 cites PMID 24755374 and reports an equal-qualified feglymycin Ki against P0A749.
feglymycin	inhibits	Staphylococcus aureus Mu50 UDP-N-acetylglucosamine 1-carboxyvinyltransferase 2	BindingDB maps this exact Standard InChIKey to a 3500 nM Ki measurement against Staphylococcus aureus Mu50 MurA2, and P65456 resolves in UniProtKB to the Mu50 murA2 gene product.	DOI:10.1016/j.bioorg.2014.03.008 reference DOI:10.1016/j.bioorg.2014.03.008 evidence type DATABASE_ASSERTION notes BindingDB own-curated row 84 cites PMID 24755374 and reports an equal-qualified feglymycin Ki against P65456.

Every edge carries its own citation; an uncited edge is refused by the corpus tests.

Molecular targets 2

Target	Target organism	Measurement	Evidence
UDP-N-acetylglucosamine 1-carboxyvinyltransferase PROTEIN BINDS UniProtKB:P0A749	Escherichia coli (strain K12) NCBITaxon:83333	KI 3400 nM	PMID:24755374 reference PMID:24755374 evidence type DATABASE_ASSERTION notes BindingDB own-curated affinity; qualifier EQUAL.
UDP-N-acetylglucosamine 1-carboxyvinyltransferase 2 PROTEIN BINDS UniProtKB:P65456	Staphylococcus aureus (strain Mu50 / ATCC 700699) NCBITaxon:158878	KI 3500 nM	PMID:24755374 reference PMID:24755374 evidence type DATABASE_ASSERTION notes BindingDB own-curated affinity; qualifier EQUAL.

Explore across X-Mech

AntibioticMech (feglymycin) ↗ MediaIngredientMech (naturalproductmech:mibig-01731d46ec) ↗ TaxonMech: Streptomyces sp. DSM 11171 (NCBITaxon:1740725) ↗ PathwayMech (mibig:BGC0001233) ↗

Provenance

Source concept	Source	Version
BGC0001233	MIBIG	5

This page is generated from data/natural_products/amino_acids_and_peptides/feglymycin.yaml, which is generated from the committed inventories. Neither is edited by hand.